Extra Flashcards
SABA PK
Onset 5-15mins, lasts 2-5hrs
SABA extra
Freq use —> tolerance
LABA PK
Onset 10-20mins, peaks in 1-2hrs, lasts 12hrs (lipophilic side chains resist degradation)
LABA dosing
Regular twice daily
LABA requires
Requires inhaled corticosteroid, can reduce steroid dose with LABA
SAMA PK
Onset 30+mins, lasts 3-5hrs
SAMA additive effect
When given with B2 agonist
LAMA PK
Onset 30-60mind, half life 27-45 hrs
LAMA hydroxyl groups
Form H bonds with receptor arginine residue
Methylxanthines extras adverse reaction
Narrow therapeutic range with small increase in plasma concentrations resulting in adverse reaction
Leukotriene receptor antagonist
Avg clinical benefits but less than low dose inhaled glucocorticoids
Corticosteroids route of deliver
Inhalation allows for lower dosing
Corticosteroids potential for ADRs
Fluticasone undergoes extensive 1st pass metabolism reducing potential for ADRs
Corticosteroids how much actually reaches lungs
<10% of fluticasone reaches lungs
Corticosteroids dose freq
Use spacer, rinse mouth & reduce dose freq to prevent localised immune suppression leading to candidiasis
