Contracindications

Question 1

SABA/LABA

Answer 1

Anxiety related symptoms, arrhythmia, atrial fibrillation, tolerance.
Tremor from skeletal muscle activation.
Vasodilation of peripheral vessels reduces BP, causing reflex tachycardia.
Hypokalaemia cause myocardial hyperexcitability

Question 2

SAMA/LAMA

Answer 2

Dry mouth, urine retention, headache, drowsy, blurred vision, constipation, diarrhoea, vomiting, palpitations, tachycardia. Don give with other anticholinerguc drugs

Question 3

Methylxanthines

Answer 3

Tachycardia & arrhythmias due to PDE inhibition. Anorexia, nausea, vomiting, nervous, insomnia, seizures

Question 4

Leukotriene receptor antagonist

Answer 4

Few ADR, long term risk of neuropsychiatric effects - suicidal, nightmares, behavioural problems

Question 5

Corticosteroids

Answer 5

Oral steroids have systemic effects. Carbs: decrease glucose uptake and utilisation, increase gluconeogenesis. Proteins: increase catabolism and decrease anabolism. Fat redistribution. Suppress HPA axis. Osteoporosis, immunosuppression and poor wound healing. Candidiasis and growth retardation.

Question 6

Cromolyns

Answer 6

Inhibit parasympathetic and cough reflexes with chronic use