Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

H > MN lec > Flashcards

MN lec Flashcards

1
Q

• inert substance added to increase tablet size or fill the capsule body

A

Diluent (Filler/ Bulking Agent)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

a.
• Most common
• No reaction with most drugs
• Monohydrate, anhydrous, and spray-dried

A

Lactose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

• Used as sweetener

A

b. Sucrose and Dextrose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

• Good flow and very compressible
• Disintegrates rapidly in water

A

c. Microcrystalline Cellulose (Avicel®)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

• Used as diluent, binder and disintegrant
• Modified Starch: Sta-Rx 1500®, Cellutab®

A

d. Starch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

• Only inorganic salt used as diluent

A

e. Dibasic calcium Phosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

• Used in chewable tablets • Negative heat of solution

A

f. Mannitol and xylitol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Diluent

A

a.Lactose
b. Sucrose and Dextrose
c. Microcrystalline Cellulose (Avicel®)
d. Starch
e. Dibasic calcium Phosphate
f. Mannitol and xylitol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

• Imparts cohesiveness to powders causing them to from granules

A
  1. Binder
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q
  1. Binder
A

a. Starch paste
b. Acacia & Tragacanth
c. Gelatin
d. Sucrose
e. Cellulose Derivatives

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

• Binder of choice for wet gran

A

a. Starch paste

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

• Natural guns

A

b. Acacia & Tragacanth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

• Protein substance

A

c. Gelatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

• Can be used as powder or syrup

A

d. Sucrose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

• Methyl cellulose
• Ethyl cellulose
• Carboxymethyl cellulose
• Hydroxypropyl methyl cellulose

A

e. Cellulose Derivatives

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

• Binder for chewable tablets

A

f. PVP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

• Facilitates the breakup of a tablet when in contact with aqueous medium

A

Disintegrant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

MOA: of disintegrant

A

Swelling
Wicking
Release of gas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

– starch paste

A

• Swelling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

• – MCC

A

Wicking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

– effervescent tablets

A

• Release of gas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

• Newer class of disintegrants which are effective at much lower levels
• Hydroscopic

A
  1. Superdisintegrant
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q
  1. Superdisintegrant
A

a. Sodium Starch Glycolate (Explotab®, Primojel®)
b. Crospovidone
c. Croscarmellose Na

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

• Cross link starch polymer

A

a. Sodium Starch Glycolate (Explotab®, Primojel®)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

• Cross link polyvinylpyrrolidone

A

b. Crospovidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

• Cross link cellulose derivative

A

c. Croscarmellose Na

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Fine powders added prior to compression to reduce friction and improve flow properties
• Mostly hydrophobic and added at low concentration

A
  1. Antifrictional Agents (Flow Activators)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Reduces friction between the tablet and die wall to facilitate ejection from die cavity

A

Lubricant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Reduces sticking to die walls and picking by punches

A

Antiadherent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Reduces friction among particles to enhance the flow

A

Glidant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

• lubricant, antiadherent and glidant

A

a. Stearates (Mg, Ca, Na)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

• lubricant and antiadherent

A

b. Purified Talc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

• glidant

A

c. Colloidal Talc
d. Colloidal SiO2 (Cab-O-Sil®)
e. Silicates (Ca and Mg)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

• hydrophilic lubricants

A

f. PEG and SLS

35
Q
  1. Antifrictional Agents (Flow Activators)
A

a. Stearates (Mg, Ca, Na)
b. Purified Talc
c. Colloidal Talc
d. Colloidal SiO2 (Cab-O-Sil®)
e. Silicates (Ca and Mg)
f. PEG and SLS

36
Q

• disguises off-color drugs and improves appearance

A
  1. Colorant
37
Q

Synthetic organic colorants
Water-soluble
Used in solution form

A

Dyes

38
Q

Dyes adsorbed on an inorganic oxide
Water-insoluble
Used in fine dispersion or
suspension form

A

Lakes

39
Q

FD&C Designation
Blue No. 1

A

Brilliant Blue FCF
Blue

40
Q

Blue No. 2

A

Indigotin
Indigo

41
Q

Blue No. 2

A

Indigotin
Indigo

42
Q

Green No. 3

A

Fast Green FCF
Turquoise

43
Q

Red No. 3

A

Erythrosine
Pink

44
Q

Red No. 40

A

Allura Red AC
Red

45
Q

Yellow No. 5

A

Tartrazine
Yellow

46
Q

Yellow No. 6

A

Sunset Yellow FCF
Orange

47
Q

masks the unpleasant taste of the drug

A

flavorant

48
Q

• cinnamon, orange cherry, butterscotch

A

a. Salty

49
Q

• chocolate, cherry, raspberry, mint

A

b. Bitter

50
Q

• raspberry, lemon, fruity

A

c. Sour

51
Q

• mint, lemon, orange

A

d. Oily

52
Q

• vanilla, fruity

A

e. Unpleasantly sweet

53
Q
  1. •masks the unpleasant taste of the drug
A

Sweetener

54
Q
  1. •masks the unpleasant taste of the drug
A

Sweetener

55
Q

Nutritive

A

• Sucrose
• Fructose
• Dextrose
• HFCS

56
Q

nutritive

A

• Sucrose • Fructose • Dextrose • HFCS

57
Q

Sugar Alcohols

A

• Mannitol
• Xylitol
• Sorbitol
• Erythritol

58
Q

Sugar Alcohols

A

• Mannitol
• Xylitol
• Sorbitol
• Erythritol

59
Q

Non-nutritive Artificial

A

• Sucralose – 1,000x
• Saccharin – 500x
• Na Saccharin – 300x
• Acesulfame K – 180-200x
• Aspartame – 180-200x
• Na cyclamate – 30x

60
Q

• – 1,000x

A

Sucralose

61
Q

– 500x

A

• Saccharin

62
Q

– 300x

A

• Na Saccharin

63
Q

– 180-200x

A

• Acesulfame K

64
Q

– 180-200x

A

• Acesulfame K

65
Q

– 180-200x

A

• Aspartame

66
Q

– 30x

A

• Na cyclamate

67
Q

Tablets

A

Dispensing
Milling
Mixing
Granulation
Tableting
Coating

68
Q

HGC

A

Dispensing
Milling
Mixing
Granulation
Filling
Sealing

69
Q

• first step in any manufacturing process
• weighing and measuring
• Objective: accuracy of weight → uniform dose
Methods:
• hand scooping and weighing
• weighing with material lifting assistance • automated dispensaries
Issues:
• weighing accuracy
• dust control (dust collecting assistance) • lot control of each ingredient
• material movement (WH → DA → PA)

A
  1. Dispensing
70
Q

• particle size reduction
• aka sizing, crushing, grinding and pulverization
• Objective: easier and more uniform mixing

A
  1. Milling
71
Q

Methods and its Equipment:

A

a. Cutting
b. Compression
c. Impact
d. Attrition
e. Combined

72
Q

Methods and its Equipment:

A

a. Cutting
b. Compression
c. Impact
d. Attrition
e. Combined

73
Q

• material is cut by means of sharp blades
• Cutter Mill – cuts particles using knives; for fibrous materials

A

a. Cutting

74
Q

• material is cut by means of sharp blades
• Cutter Mill – cuts particles using knives; for fibrous materials

A

a. Cutting

75
Q

• material is crushed by application of pressure
• End Runner Mill – mortar rotates
• Edge Runner Mill – 2 rotating wheels

A

b. Compression

76
Q

• material is crushed by application of pressure
• End Runner Mill – mortar rotates
• Edge Runner Mill – 2 rotating wheels

A

b. Compression

77
Q

• material is hit by an object or it strikes a stationary phase
• Hammer Mill – 4 or more hammers hinged on a shaft

A

c. Impact

78
Q

• material is hit by an object or it strikes a stationary phase
• Hammer Mill – 4 or more hammers hinged on a shaft

A

c. Impact

79
Q

• material is crushed in between rubbing surfaces
• Roller Mill – 2 metal cylindrical rolls rotating

A

d. Attrition

80
Q

• Utilizes both impact and attrition methods
• Ball Mill – hollow cylinder containing balls
• Fluid Energy Mill – uses air with very high pressure

A

e. Combined

81
Q
  1. • blending materials together into one mass
    • Objectives:
    • uniform dose
    • even appearance
    • avoid segregation
A

Mixing

82
Q

Equipment:

A

a. Batch Type Mixer
b. Continuous Mixer

83
Q

• all ingredients are loaded together, mixed for a long period, and discharged as a single batch

A

a. Batch Type Mixer

84
Q

a. Batch Type Mixer

A

Rotating Shell/ Tumbling Mixers
Fixed Shell Mixers

H (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions