MM

Question 1

VELCDE SPECIAL CONSIDERATIONS

Answer 1

DOASGE 3.5 1,4,8,11 OF 21 DAYS CYCLE
IN ELDELRY 1, 81 15, 22 IN 35 DAYS CYCLE
HSV PROPHYLAXIS
DO NOT START IF: PLT < 70K ANC < 1000
WITHHOLD IF: PLT <30K ANC <750
CONSIDER SQ IF HIGH RISK FOE NEUROPATHY
MAY CAUSE PRESS/PML/TMA
CHECK HBV STATUS
HEPATIC METABLOLISM

Question 2

DEXAMTHASONE

Answer 2

20 MG OR 40 MG ONCE WEEKLY

Question 3

LENALIDOMIDE

Answer 3

DOSAGE 25 MG (10 FOR ELDERLY) QD FOR 21 DAYS OF 28 DAYS CYCLE
CORRECTOIN FOR RENAL IMPAIRMENT
PLT < 30K ANC< 500 OR 1K WITH FEVER WITHHOLD
REDUCE DOSE BY 5 FOR EACH TIME

B HCG TEST FOR FERTILE WOMEN
RISK MANGMNET FORM FOR ALL PTS
VTE PROPHYLAXIS
NEUTROPENIA ADN THROMBOCYTOPENIA ARE COMMON
SJS
INCREASED MORTALITY IN COMBONATION WITH PEMBROLIZUMAB

Question 4

THALIDOMIDE

Answer 4

IN COMBINATION WITH DRD- 100 MG QD FOR 4 CYCLES- ASCT- AND MORE CYCLES
IN COMBINATION WITH RD - 100 MMG FOR 14 DAYS, 200 MG FOR 21 DAYS
TAKE AT BEDTIME
NO RENAL IMPAIRMENT NEED
ANC < 750 WITHHOLD

Question 5

DARATUMUMAB

Answer 5

16 MG ONCE A WEEK FOR 8 WEEKS

THEN 16 MG ONCE EVERY TWO WEEKS