MDS

Question 1

Azacitidine dosage

Answer 1

S.C.
75 mg/m^2
7 days of 28 day cycle

Question 2

Azacytidine trials

Answer 2

CAGLB 9221
AZA-001
Both P3 DBRT
Included high risk IPSS or int2 (today considerd AML/MDS)
Better OS (arounf 20-25 months vs 15 mo)

Question 3

Azacytidine SE

Answer 3

Myelosuppression
Neutropenia 80%
Thrombocytopenia 70%
N/V
Diarrhea/constipation
Weakness, dizziness, arthralgia, headache

Question 4

Azacytidine practical points

Answer 4

AZA-7 is difficult in outpt setting so AZA-5-2 is more common. AZA-5 is also an option and is comparable. though not recommended for high risk.
N/V prophylaxis is warranted

Question 5

Azacytidine duration of Tx

Answer 5

Until pregresssion

Question 6

Azacytidine Supportive Tx