MLS 314 Cutaneous mycoses Flashcards
Involves deeper layers of the skin
CUTANEOUS MYCOSES
→ moderate to intense inflammatory reaction
CUTANEOUS MYCOSES
2 Types of CUTANEOUS MYCOSES
- Dermatomycoses
- Dermatophytoses
- Caused by fungi other than the dermatophytes
Dermatomycoses
Involves only the skin
Dermatomycoses
Caused by dermatophytes
Dermatophytoses
“True cutaneous mycoses”
Dermatophytoses
May involve the skin, hair, & nails
Dermatophytoses
- Other names
o “Buni”
o Ringworm
o Tinea
DERMATOPHYTOSES
Characteristic lesion: Circular & expanding inflammatory region
DERMATOPHYTOSES
- Causative agent: Dermatophytes
o “Plants of the skin”
o Keratinophilic fungi: Production of keratinase
DERMATOPHYTOSES
Arthroderma (Nannizia)
Skin and hair
Microsporum
Arthroderma
Skin, hair, and nails
Trichophyton
None
Skin and nails
Epidermophyton
Microsporum audouinii
Trichophyton mentagrophytes var interdigitale
Trichophyton rubrum
Trichophyton tonsurans
Trichophyton concentricum
Trichophyton schoenleinii
Trichophyton violaceum
Epidermophyton floccosum
Anthropophilic
Microsporum canis
Trichophyton mentagrophytes var mentagrophytes
Trichophyton verrucosum
Zoophilic
Microsporum gypseum
Geophilic
2 Clinical classification of DERMATOPHYTOSES:
- Skin and Nail Infections
- Hair Infection Types
▪ Trunk and limbs; Shoulder, neck region, and arms
Tinea corporis
▪ Causative agents: M. canis, T. mentagrophytes, T. rubrum, T. tonsurans
Tinea corporis
▪ Areas adjacent to scalp, eyebrows, eyelashes
Tinea capitis
▪ Causative agents: Microsporum, Trichophyton
Tinea capitis
▪ “Barber’s itch”
Tinea barbae
▪ Bearded area, neck
Tinea barbae
▪ Causative agents: T. mentagrophytes, T. verrucosum, T. schoenleinii
Tinea barbae
▪ “Jock Itch”
Tinea cruris
▪ Groin, inner thighs, buttocks
Tinea cruris
▪ Causative agents: T. rubrum, T. mentagrophytes, E. floccosum
Tinea cruris
▪ Feet ; “Athlete’s foot”
Tinea pedis
▪ Causative agents: T. rubrum, T. mentagrophytes var interdigitale, E. floccosum
Tinea pedis
▪ Hands
Tinea manuum
▪ Causative agents: M. canis, T. mentagrophytes var interdigitale, T. rubrum, T. tonsurans
Tinea manuum
Onychomycosis
Tinea unguium
▪ Nails
Tinea unguium
▪ Causative agents: T. mentagrophytes , T. rubrum, T. schoenleinii, T. violaceum, E. floccosum
Tinea unguium
▪ Specialized form of tinea corporis
Tinea imbricata
▪ Ring-like growth in overlapping patterns/ circles
Tinea imbricata
▪ Causative agents: T. concentricum
Tinea imbricata
▪ Growth of fungal elements on the outer part of the hair shaft
Ectothrix infection
▪ Causative agents
o Trichophyton mentagrophytes
o Trichophyton verrucosum
o Microsporum audouinii
Ectothrix infection
▪ Hyphae → fragment to individual cells → development of arthroconidia
Ectothrix infection
▪ Can destroy hair cuticle
Ectothrix infection
▪ M. audouinii: Hair becomes gray on color and breaks off → grayish patch in the scalp → “GRAY-PATCH” Tinea capitis
Ectothrix infection
▪ Causative agents
o Trichophyton tonsurans
o Trichophyton violaceum
Endothrix
▪ Growth of fungal elements inside the hair shaft
Endothrix
▪ Development of arthroconidia; Does not usually destroy the cuticle
Endothrix
▪ Hair becomes brittle → breaks off just above the surface of the scalp → “BLACK DOT” Tinea capitis
Endothrix
▪ Causative agent: T. schoenleinii
Favic type
▪ Hyphae within the hair shaft → growth of hyphae parallel to the hair shaft→ degeneration of hyphae → tunnels within hair shaft
Favic type
▪ No development of arthroconidia
Favic type
▪ Severe form: Scutula
o Yellowish, circular lesions with a characteristic “mousy” odor
Favic type
▪ Hypersensitivity reaction to dermatophytic infection elsewhere in the body
Dermatophytid reaction
Specimens of CUTANEOUS MYCOSES
▪ Skin scrapings
▪ Hair
▪ Nail clippings
Exposure to Wood’s Light
CUTANEOUS MYCOSES
- Hyphae
o Small: 2-3 microns
o Hyaline, septate, branching
KOH Preparation
- Presence of arthroconidia: Endothrix and ectothrix infection vs Faciv type
KOH Preparation
- Branching, sometimes fluorescing hyphae
Calcofluor white staining
- Disadvantage of not being able to inhibit growth of saprophytic fungi
Nonselective SDA
- Incubation: 25-300C for 1-3 weeks
Nonselective SDA
- Selective SDA
Mycosel/ Mycobiotic