MLA Flashcards
MI complications, left ventricular aneurysm
Persistent ST elevation
LV failure - pulm oedema
S3 sounds - LV larger
S4 sounds - LV stiffer
Anticoag as risk of thrombus
Left ventricular free wall rupture
1-2 weeks after
Acute HF 2ndry to cardiac tamponade, raised JVP, pulses paradox, HS muffled
Hypotension
Acute mitral regurg
More common in infero post infarction
Papillary muscle rupture
Acute hypotension, flash pulmonary oedema
Early to mid systolic murmur
Vasodilator therapy, surgery
MI complication, Ventricular septal defect
occur in 1st wk
new pan systolic murmur
Raised JVP
SOB, bibasal crackles
Dressler’s syndrome post MI
pleuritic pain, left, pericardia effusion
Saddle shape st elev on ecg
After MI 2-6wks
Tx - nsaids
MI complic, bradyarrhythmia
- AV block common after inferior MI -> HB
Drugs causing drug induced liver disease
Paracetamol
sodium valproate, phenytoin
MAOIs
halothane
anti-tuberculosis: isoniazid, rifampicin, pyrazinamide
statins
alcohol
amiodarone
methyldopa
nitrofurantoin
drug induced cholestasis
COCP
antibiotics: flucloxacillin, co-amoxiclav, erythromycin*
anabolic steroids, testosterones
phenothiazines: chlorpromazine, prochlorperazine
sulphonylureas
fibrates
P450 enzyme inducers (inc other drugs metabolism, reduce therapeutic conc)
Antiepileptics: phenytoin, carbamazepine
barbiturates: phenobarbitone
rifampicin
St John’s Wort
chronic alcohol intake
griseofulvin
smoking
P450 enzyme inhibitors, inc therapeutic concentration
Ciprofloxacin, erythromycin
isoniazid
cimetidine, omeprazole
amiodarone
allopurinol
imidazoles: ketoconazole, fluconazole
SSRIs: fluoxetine, sertraline
ritonavir
sodium valproate
acute alcohol intake
Palliative med, what medication is started with
modified release morphine or standard release
laxative co prescribed
what is the breakthrough dose for morphine
1/6 of total dose
What is used for metastatic bone pain
opioids
bisphosphonates
radiotherapy
what is the drug conversion of oral codeine/tramadol to oral morphine
divide by 10
drug conversion oral morphine to oral oxycodone
divide by 1.5
what opioid is used in mild moderate renal impairment
oxycodone
what opioid is used in severe renal impairment
alfentanil,
buprenorphine,
fentanyl
conversion for oral morphine to s/c morphine
divide by 2
oral morphine -> subcut diamorphine
divide by 3
oral oxycodone -> subcut diamorphone
divide by 1.5
Mechanism of action metformin
Biguanide
Inc insulin sensitivity
Dec hepatic gluconeogenesis
DDP-4 inhibitor
Increase active incretin levels
Reduce peripheral breakdowns of incretins
Pioglitazone
inc insulin sensitivity
Sulfonyurea
Inc insulin release from pancreas