Homeostasis extra Flashcards
1
Q
What coagulation tests are done for primary homeostasis
A
platelet count
bleeding time
2
Q
What coagulation tests are done for secondary homeostasis
A
PT - extrinsic pathway
APTT - intrinsic pathway
3
Q
Direct thrombin inhibitor drugs?
A
Dabigatran, argatroban
4
Q
Xa inhibitor drugs?
A
Rivaroxaban, edoxaban, apixaban
5
Q
Mechanism of action of heparins
A
Xa and thrombin inhibitors
6
Q
Mechanism of action of warfarin
A
Vit K antagonist
inhibit factor 2, 7, 9, 10
factor 2 (prothrombin)
7
Q
What is part of the intrinsic pathway
A
factor 8, 9, 11, 12
8
Q
What is part of the extrinsic pathway
A
factor 7 and tissue factor
TF activates 7 which activates factor 10
9
Q
What does protein C and S do
A
inactivates factor 5a and 8a
