MK - Intro to Pharmacology II

Question 1

What are muscarinic receptors?

Answer 1

G-coupled protein receptors involved in the parasympathetic nervous system

Question 2

What molecule activates muscarinic receptors?

Answer 2

Acetylcholine

Question 3

How does atropine bind with muscarinic receptors?

Answer 3

Inhibits muscarinic acetylcholine receptors

• Competitively blocks the effects of Ach

Question 4

How do partial agonists act as competitve antagonists?

Answer 4

Occupy the receptor and produce a lower maximum efficacy

Question 5

What are some examples of receptor locations? (5)

Answer 5

Enzymes
Carrier Proteins
Nucleic acids
Metabolism
Neurotransmission

Question 6

What are the 2 receptor subtypes?

Answer 6

Nicotinic receptors

• Function within the CNS and at the neuromuscular junction.

Muscarinic receptors

• Function in both the PNS and CNS, mediating innervation to visceral organs

Question 7

What are some features of the muscarinic receptor? (2)

Answer 7

G-Protein coupled receptors

• Found in intestinal smooth muscle, salivary glands and CNS

Question 8

What are some features of the nicotinic receptor? (2)

Answer 8

Ligand-gated ion channels

• Found in skeletal muscle, ganglia, CNS

Question 9

What are some features of the insulin receptor? (2)

Answer 9

Tyrosine kinase receptor

• Found on the surfaces of most cells in the human body

Question 10

What are some features of the Glucocorticoids receptor? (2)

Answer 10

Nuclear receptor

• Found throughout the body

Intracellular receptors are transcription factors that interact with DNA in the nucleus and regulate gene expression

Question 11

What alterations of drug structure can impact its activity? (5)

Answer 11

1) Charge
2) Methyl groups
3) Ester linkage
4) Distance
5) to the chain