Mitral Regurgitation Flashcards
what does acute mitral regurgitation present with?
- sudden onset pulmonary oedema
- hypotension
- cardiogenic shock
what are the broad causes of acute mitral regurgitation?
- ischaemic MR
- non-ischaemic MR
- prosthetic valve MR
decribe ischaemic causes of acute mitral regurgitation
due to papillary muscle rupture secondary to MI
decribe non-ischaemic causes of acute mitral regurgitation
chordae tendineae rupture
* myxomatous disease (mitral prolapse)
* infective endocarditis
* rheumatic heart disease
* trauma
* spontaneous rupture
describe the prosthetic valve causes of acute mitral regurgitation
- tissue valvelet rupture due to endocarditis, degeneration or calcification
- paravalvular regurgitation due to infection or suture rupture
- valve thrombus or infection causing impaired closure
what are the broad categories of causes of chronic mitral regurgitation?
- leaflet related causes
- chordae related causes
- papillary muscle related causes
- annular related causes
- prosthesis related causes
describe leaflet related causes of chronic mitral regurgitation
- degenerative disease
- rheumatic fever - presents typically in younger patients
- infective endocarditis
- systemic inflammatory disorder - e.g. SLE, scleroderma
- connective tissue disorder - e.g. marfan’s, ehlers-danlos syndromes
- congenital causes
- hypertrophic cardiomyopathy
- drug related damage
describe chordae related causes of chronic mitral regurgitation
- myxomatous valve disease
- trauma
describe papillary muscle related causes of chronic mitral regurgitation
- MI
- dilated cardiomyopathy
describe annular related causes of chronic mitral regurgitation
- calcifcation - either due to rheumatic fever or age-related
- diltation
describe prosthesis causes of chronic mitral regurgitation
- paravalvular leak
- ring or strut fracture
- leaflet deterioration in tissue valves
- infective endocarditis
- thrombus or pannus formation
what are the complications of mitral regurgitation?
- heart failure
- thromboembolism secondary to AF
- haemoptysis secondary to pulmonary hypertension
- infective endocarditis
what is the typical presentation of chronic mitral regurgitation?
may be asymptomatic - until systolic dysfunction, pulmonary hypertension or AF
* atrial fibrillation
* fatigue
* exertional dyspnoea
what is the typical presentation of acute mitral regurgitation?
- shortness of breath
- exertional dyspnoea
- fatigue
- weakness
typically have pulmonary oedema, hypotension and signs of cardiogenic shock
describe the auscultation in mitral regurgitation
pansystolic murmur
* loudest at the apex
* radiates to the axilla
* louder on expiration and on rolling to the left
* S1 may be quite or absent