Mitosis & Meiosis Flashcards
What are the molecular regulators of Mitosis?
- Cyclins
- Cyclin-Dependent kinases
- Anaphase Promoting Complex (APC/C)
(T/F) Expression of Cyclins rise and fall depending on phase.
T
(T/F) Expression of Cyclin-dependent kinases rise and fall depending on phase.
F
Which cyclin is highly expressed at the beginning of S-Phase?
Cyclin E
Which cyclin is highly expressed at the beginning of G2-Phase?
Cyclin A
Which cyclin is highly expressed at the beginning of Mitosis-Phase?
Cyclin B
Which CDK is responsible for G1 phase?
CDK-4
Which CDK is responsible for S phase?
CDK 2
Which CDK is responsible for M phase?
CDK 1
What activates the Anaphase Promoting Complex?
M Phase Promoting Factor (MPF)
What must be inactivated, and what inactivates it, in order for cyclin E to be synthesized?
- The tumor supressor Retinoblastoma (Rb)
- Inactivated by CDK4 and 6
What enzyme controls entry into the M Phase?
cdc25 phosphatase
What does cdc25 Phosphatase do?
- initiates the M Phase
- Removes inhibitory units from MPF complex
What stage of meiosis do female gametes halt in until puberty?
Prophase I
When does meiosis II start in female gametes?
Upon ovulation
