mitosis Flashcards
what 4 events are needed for cell division
- reproductive signal
- DNA replication
- DNA segregation
- Cytokinesis
when is DNA replicated
in the S phase, during interphase
function of cohesins
to tie together DNA sister chromatids after replication
when do centromeres duplicate
in G1/S
what 2 cytoskeletal structures assist mitosis and cytokinesis
mitotic spindle for chromosome segregation and contractile ring
what are the 3 kinds of microtubules
aster: help center the spindle fiber and anchor to cortes and pull apart spindle poles
kinetochore: make contact with chromosomes
interpolar: grow from opposite ends and overlap at the spindle equator
vinca alkaloids
destabilize microtubules
taxanes
stabilize microtubules
the M phase consists of
mitosis and cytokinesis
mitosis is made up of
5 stages
prophase
chromosome condensation and kinetochore assembly, mitotic spindle starts to assemble, nuclear envelope is intact
condensins
help coil sister chromosomes into compact structures
prometaphase
nuclear envelope is disrupted, chromosomes attach to mitotic spindle
metaphase
chromosomes line up at equator
anaphase
degradation of cohesins by proteolysis, synchronous separation of sister chromatids
