Mitochondrial Bioenergetics

Question 1

PDC function, states, and regulation

Answer 1

Enzyme responsible of decarboxylating Pyruvate to Acetyl CoA. Inactive in the phosphorylated form.
Inhibited by Acetyl CoA, ATP, NADH.
Activated by Pyruvate and ADP.

Question 2

What is the rate limiting step in TCA Cycle?

Answer 2

Isocitrate Dehydrogenase.

Question 3

What does the Malate-Aspartate shuttle transport and in which complex?
In which organs does it operate?

Answer 3

NADH. Complex 1. It operates in heart, kidney and liver.

Question 4

What does the Glycerophosphate-shuttle transport and in which complex?
In which organs does it operate?

Answer 4

FADH2. Joins ETC at Coenzyme Q.

Operates in Skeletal muscles and brains.