Membranes and Transport Flashcards
What are the 2 different types of Phospholipids? Give examples
Glycerophospholipids: Phosphatidylserine, Phosphatidylcholine
Sphingolipids: Sphingomyelin
Glycolipids: Structure and location
Sphingosine backbone and carbohydrate residues. Found in the outer leaflet of the lipid bilayer.
On which sheet of the Plasma membrane are Phosphatidylcholine, Glycolipids, and Sphingomyelin located? (inner or outer?)
On the outer side of the membrane.
On which sheet of the Plasma membrane are Phosphatydilserine, Phosphatydilinositol and Phosphatydillethanolamine located? (inner or outer)?
Inner side of the membrane
Niemann-Pick Disease
Caused by deficiency of Sphingomyelinase. Sphingomyelin is accumulated and causes enlarged liver, and spleen and causes neurological problems.
Also called “cherry red spot”
Glycocalix: definition and functions
It is a carbohydrate cell.
It’s functions are: Protection, Cell adhesion and cell identification.
Erythroblastis fetalis
Disease in which incompatibility between the mother(Rh-) and the fetus blood (Rh+)
Spur cell Anemia
It is a type of hemolytic anemia. It is caused by high levels of cholesterol in RBC membrane. Decreases fluidity and flexibility of membrane.
What is Mimantine/Namenda?
Antagonist of Glutamate receptor used to treat Alzheimer’s disease.
Is the ATP hydrolyzed in the ABC Transporters?
Yes, but it does not phosphorylate the protein. E.g.: glycoproteins.
Cystinuria
caused by a defect in the transport responsible for uptake of dimeric amino acid Cystein and the dibasic amino acids: Arg, Lys, and Ornithine. Result in the formation of Cysteine stones in the kidney.
Hartnup Disease
Caused by a defect in the transport of non polar Amino acids, specifically Trp. Transporter is found in the intestine and kidney primarily.
AKA Pellagra like dermatitis.
