mitochondria

Question 0

what are the ways in which mitochondria produce acetyl CoA

Answer 0

• pyruvate of FA metabolism
• ketone body synthesis
• TCA cycle
• oxidative phosphorylation

Question 1

what is the range of the number of mitochondria in the cells

Answer 1

200-10,000

Question 2

what are ragged red fibres

Answer 2

the hallmark of mitochondrial disorders in microscopy

- red subsarcolemmal deposits in sections of muscle

Question 3

what can cause a change in the respiratory chain cycle

Answer 3

defect in either the mitochondrial DNA or the nuclear DNA

Question 4

how does pyruvate get into the mitochondria

Answer 4

has 2 transporters across the inner cell membrane

Question 5

what do you produce in one turn of the Krebs cycle

Answer 5

3 NADH
1 FADH2
1 GTP

Question 6

what does ATP synthase require

Answer 6

an intact cell membrane

Question 7

which respiratory complex is not encoded by mitochondrial DNA

Answer 7

complex 2

Question 8

how does H+ leak back through the mitochondrial membrane without ATP production

Answer 8

by uncoupling oxidative phosphorylation

Question 9

what is the malate-aspartate shuffle

Answer 9

transfers the reducing power of NADH from the cytosol to the mitochondria for oxidative phsophorylation

Question 10

which substrate in muscle can be used to dump energy quickly

Answer 10

glycerol-3-phosphate –> dumps energy straight into complex 2