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Blood Bank > Miscellaneous II > Flashcards

Miscellaneous II Flashcards

1
Q

Pk receptor for…

A

Shiga toxin

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2
Q

Probability of not finding a compatible unit

A

(1-antigen neg freq)^#of units

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3
Q

Probability of finding exactly one compatible unit

A

of units x antigen neg freq x (antigen pos freq)^(# of units - 1)

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4
Q

Normal plasma viscosity

A

1.5-1.8 Ostwald units

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5
Q

Hyperviscosity

A

4-60 Ostwald units

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6
Q

Monochloraoacetic acid lysis test measures which factor?

A

FXIII

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7
Q

t1/2 FVII

A

4-6 hrs

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8
Q

t1/2 FVIII

A

8-12 hrs

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9
Q

t1/2 FIX

A

18-24 hrs

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10
Q

t1/2 FXIII

A

144 hrs

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11
Q

FVIII dosage

A

= desired change in FVIII x (1-HCT) x kg

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12
Q

FIX dosage

A

= [desired change in FIX x (1-HCT) x kg] x 2

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13
Q

Dose of vit K with high INR without bleeding

A

1 mg

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14
Q

Dose of vit K with high INR with bleeding

A

5-10 mg

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15
Q

Risk of HTLV from transfusion

A

1/3 million

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16
Q

Risk of WNV from transufsion

A

1/7 million

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17
Q

Risk of bacterial contamination (RBC)

A

1/30,000

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18
Q

Risk of bacterial contamination (PLT)

A

1/5,000

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19
Q

Risk of septic transfusion reaction (RBC)

A

1/500,000

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20
Q

Risk of septic transfusion reaction (PLT)

A

1/75,000

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21
Q

Risk of fatal septic transfusion reaction (RBC)

A

1/10,000,000

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22
Q

Risk of fatal septic transfusion reaction (PLT)

A

1/500,000

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23
Q

Lifetime persistence of asymptomatic infection with this species of plasmodium?

A

malariae

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24
Q

Chagas most commonly transmitted in which blood product component

A

PLT

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25
Q

Cord blood, mother should have ID testing performed when?

A

7 days before of after delivery

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26
Q

Minimum CD34 cell dose

A

2 x 10^6 (target 5 x 10^6)

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27
Q

Autologous PBCs stimulated with G-CSF a/w faster engraftment of granulocyte (__days) and platelets (___days)

A

10, 14

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28
Q

Percentage of CD34+ cells in normal marrow

A

1-3%

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29
Q

Best to collect PBCs when peripheral CD34 cell count ____

A

> 5cells/ul (WBC 5000/ul used as surrogate)

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30
Q

If peripheral CD34 count 10cells/ul then collection will yield at least _____

A

1 x 10^6 /kg

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31
Q

Minor mismatch in HPC transplant a/w

A

immediate hemolysis

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32
Q

Major mismatch in HPC transplant a/w

A

delay in RBC recovery and risk of red cell aplasia

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33
Q

Thawed HPC products should be infused within

A

1 hour (if longer than wash)

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34
Q

How long and at what temperatures can HPC harvested from marrow be kept in refrigeration (not freezer)?

A

2-8C for 3 days

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35
Q

How long and at what temperatures can HPC harvested from peripheral blood be kept in refrigeration (not freezer)?

A

4-15C for 3 days

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36
Q

ABO mismatch results in _____ day delay of RBC recovery

A

40-60 day

37
Q

Dose of G-CSF

A

10 ug/kg/day (daily starting 4 day prior to collection and then continue through collection)

38
Q

Normal percentage of peripheral CD34 cells

A

0.05%

39
Q

Plerixafor dose

A

0.24 mg/kg (daily starting 4 days after G-CSF, ~11 hrs prior to collection)

40
Q

Plerixafor approved for patients with … (2)

A

NHL and multiple myeloma (autologous transplants)

41
Q

G-CSF: do not use in patients with ___ or with WBC > ____ due to leukostasis

A

SCD/60

42
Q

1901

A

ABO discovery by Landsteiner

43
Q

1939

A

anti-D by Levin and Stetson

44
Q

1902

A

AB group discovery by Von Descatello and Sturli

45
Q

1944

A

AHG described by Moreshi, and then by Coombs in 1945

46
Q

Autocontrol with HTLV can be positive with this antibody

A

anti-JMH

47
Q

Antibody to this single antibody can lead to varying strength of activities on antibody panel due to variability in expression

A

P1

48
Q

Glycoprotein containing HPA1

A

GPIIIa

49
Q

Glycoprotein containing HPA2

A

GP1b

50
Q

DDAVP dose

A

0.3 ug/kg IV in 30-50 mL NS

51
Q

Glycoprotein containing HPA3

A

GPIIb

52
Q

Fibrinogen dosing

A

1 unit/7-10 kg

53
Q

TRALI incidence

A

1:1300 - 5000

54
Q

Incidence of ABO HDN

A

1/500

55
Q

Incidence of severe ABO HDN

A

1/3000

56
Q

Materno-fetal ABO incompatibility

A

20% of pregnancies

57
Q

1500 IU WinRho equivalent to how many ug of RhoGam

A

300

58
Q

Most common antibody implicated in NAIT in Asians

A

anti-4a

59
Q

Risk of ICH a/w NAIT

A

10-30% when PLT

60
Q

Incidence of HTR ABO

A

1/33,000

61
Q

Incidence of TA-GVHD

A

1/400,000

62
Q

Incidence of PTP

A

1/200,000

63
Q

% of patients on penicillin with a + DAT

A

3

64
Q

All establishments that manufacture (process, collect, freeze, thaw, deglyceralize, wash, leukoreduce) blood components must be ______ with the FDA

A

registered

65
Q

All establishments that participate in interstate commerce must be _____ with the FDA

A

liscenced

66
Q

Monitored temperatures must be recorded this often

A

Q 4 hrs

67
Q

Increased beta-glucosyltranserase activity that can incorporate UDP-N-acetylgalactasamine in addition to UDP-galactose can lead to this phenotype

A

B(A) phenotype

68
Q

IgG subclass that does not cross placenta

A

IgG2

69
Q

Single donor PLT contains this much fibrinogen

A

80 mg

70
Q

Apheresis PLT contains this much fibrinogen

A

150 mg

71
Q

Unit of FFP contains this much fibrinogen

A

400 mg (~2mg/ml)

72
Q

Single unit of cryo can raise fibrinogen this much

A

7mg/dL (so pool can raise 70 mg/dL)

73
Q

increased i expression in (hint 2 disease types)

A

CDA II and Blackfan-Diamond Syndrome

74
Q

Rh null cells also have decreased amounts of the following antigens (5)

A
  1. LW
  2. Fy5
  3. S
  4. s
  5. U
    (Glycophorin B)
75
Q

anti-body made by Rh null individuals

A

anti-Rh29

76
Q

2 populations with increased incidence of Jk(a-b-)

A

Polynesians and Finns

77
Q

Individuals with SCD have increased amounts of this antigen

A

Lutheran

78
Q

definition of hard spin

A

5000g for 5-7 min

79
Q

definition of soft spin

A

2000g for 3 min

80
Q

False positive rosette test

A

mother is a weak D or partial D

81
Q

False negative rosette test

A

baby is a weak D

82
Q

Gauge of needle for transfusion for adults

A

18-20

83
Q

Gauge of needle for transfusion in children

A

23-25

84
Q

transfusion filters should be changed how often?

A

4 hrs

85
Q

Indications for exchange transfusion in an infant (4)

A
  1. Cord hgb 3 mg/dL
  3. Rate of bilirubin rise >0.5 mg/dL/h during first 48 hr
  4. Projected bili peak in 3 days of 15 - 20 mg/dL or higher
86
Q

Double-exchange (one donor unit) decreases bili by how much?

A

50%

87
Q

RBC transfusion trigger in neonates with severe cardiopulmonary disease

A

13 g/dL

88
Q

RBC transfusion trigger in neonates with moderate cardiopulmonary disease

A

10 g/dL

89
Q

RBC transfusion trigger in neonates with symptomatic anemia

A

8 g/dL

Blood Bank (14 decks)

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