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Blood Bank > Antibodies and such > Flashcards

Antibodies and such Flashcards

1
Q

Guinea pig urine

A

Sd(a)

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2
Q

Hydatid cyst fluid

A

P1

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3
Q

Saliva

A

H, Le(a)

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4
Q

Breast milk

A

I

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5
Q

Pigeon eggs

A

P1

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6
Q

Plasma

A

Chido, Rodgers

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7
Q

Dolichos biflorus

A

A1

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8
Q

Bandeiraea simplicifolia

A

B

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9
Q

Ulex europeus

A

H

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10
Q

Lotus tetragonolobus

A

H

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11
Q

Arachis hypogaea

A

T

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12
Q

Vicea graminea

A

N

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13
Q

Significant HTLAs

A

Cartwright (Yt(a)), Holley (Hy), Gregory (Gy)

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14
Q

Insignificant HTLAs

A

Chido/Rodgers (Ch/Rg), Sd(a), Cs(a), Kn(a), York (Yk(a))

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15
Q

Antigens enhanced by enzymes

A

AB, Le, I/i, P, Rh, Kidd

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16
Q

Antigens decreased by enzymes

A

MNS, Fy(a), Fy(b), Luteran, Chido, Rodgers, Yt(a)

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17
Q

Antigens unaffected by enzymes

A

Kell

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18
Q

Frequency of D

A

85%

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19
Q

Frequency of C

A

70%

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20
Q

Frequency of c

A

80%

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21
Q

Frequency of E

A

30%

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22
Q

Frequency of e

A

98%

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23
Q

Frequency of G (CD)

A

84%

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24
Q

Frequency of f (ce)

A

65%

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25
Q

Frequency of K

A

10%

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26
Q

Frequency of Jk(a)

A

75%

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27
Q

Frequency of Jk(b)

A

75%

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28
Q

Frequency of Fy(a)

A

65%

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29
Q

Frequency of Fy(b)

A

83%

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30
Q

Frequency of M

A

80%

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31
Q

Frequency of N

A

72%

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32
Q

Frequency of S

A

55%

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33
Q

Frequency of s

A

90%

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34
Q

Frequency of U

A

99.9%

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35
Q

Frequency of P1

A

80%

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36
Q

Frequency of Jk(a-,b-)

A

rare, except in Pacific Islanders (1:400)

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37
Q

Frequency of Fy(a-,b-)

A

rare in whites, 68% in blacks

38
Q

3 reasons that Rh+ patient with anti-D antibody

A
  1. auto antibody with Rh specificity
  2. Partial D with antibody
  3. Alloantibody anti-LW (LW closely associated with D antigen, so may appear to be an anti-D antibody)
39
Q

Noncovalent coating of RBCs with drug with which the patient has an antibody; dose dependent

A

Drug adsorption (hapten) mechanism

40
Q

Type of hemolysis associated with Drug adsorption (hapetn) mechanism

A

extravascular hemolysis

41
Q

Prototypic drugs of Drug adsorption (hapetn) mechanism

A

penicillin (3% have positive DAT, of which 5% have hemolysis)

42
Q

Drug becomes adsorbed to the RBC membrane and subsequently becomes coated with antibody that can bind complement

A

Drug dependent antibody mechanism

43
Q

Type of hemolysis of Drug dependent antibody mechanism

A

intravascular hemolysis

44
Q

Prototypic drug of Drug dependent antibody mechanism

A

Piperacillin, cephalosporins

45
Q

Drug induces red cell autoimmunity that persists after withdrawal of the agent (drug independent) - autoantibody directed against an innate component of red cell membrane and indistinguishable from those that cause idiopathic WAHA

A

Autoimmune induction mechanism

46
Q

Prototypic drugs of Autoimmune induction mechanism

A

Methyldopa, levodopa, procainamide, fludarabine, 2nd and 3rd generation cephalosporins

47
Q

Drug induced nonspecific, nonimmune, binding of immunoglobulin to the red cell surface; non specific adsorption of albumiin, IgG, IgA, IgM, and complement to RBC membrane, no antibody production (eluates are negative)

A

Nonimmune protein adsorption mechanism

48
Q

Prototypic drug of Nonimmune protein adsorption mechanism

A

Cephalothin

49
Q

Frequency of C(w)

A

2%

50
Q

Frequency of V

A

1%

51
Q

En(a) negative genotype

A

MN null

52
Q

MkMk genotype

A

MNSs null

53
Q

McLeod genotype

A

Kx null

54
Q

All cells in panel and autocontrol positive at AHG only

A

warm autoantibody

55
Q

All cells in pane, except autocontrol, positive at AHG only, weak (1+/2+)

A

HTLA

56
Q

All cells in panel and autocontrol positive only at IS

A

cold autoantibody

57
Q

All cells in panel and autocontrol positive at IS and 37C, not at AHG

A

antibody to reagents

58
Q

IgG subtype that does not cross the placenta

A

IgG2

59
Q

3 reasons for cord sample with positive DAT and negative maternal antibody screen

A
  1. ABO HDN
  2. RhIg
  3. Low incidence antigen not on screen
60
Q

antibody associated with renal dialysis

A

anti-Nf

61
Q

antigen that is an epitope on band 3 protein

A

Diego (null phenotype cases HS, HE, acanthocytosis)

62
Q

Epitope on glycophorin C; null phenotype is a cause of HE

A

Gerbich (Leach phenotype)

63
Q

Clinically significant HTLAs

A

Cartwright (Yt), Holley (Hy), Gregory (Gy)

64
Q

Low incidence antigens

A

Wr-a, Kp-a

65
Q

Le(a)

A

CA19.9 epitope

66
Q

Le(b)

A

Norwalk

67
Q

O frequency in CS/AA

A

44/50

68
Q

A frequency in CS/AA

A

40/25

69
Q

B frequency in CS/AA

A

11/20

70
Q

AB frequency in CS/AA

A

4/5

71
Q

D frequency in CS/AA

A

85/92

72
Q

Bga

A

HLA-B7

73
Q

Bgb

A

HLA-B17

74
Q

Bgc

A

HLA-A28/A2

75
Q

Glycine Max

A

Tn

76
Q

A3

A

mf agglutination

77
Q

Le(a-b-) individuals at risk for

A

Candida and E. coli infections

78
Q

Which population has a higher prevalence of i-adult phenotype

A

Asians

79
Q

Le(b) receptor for (2)

A

H. pylori and Norwalk

80
Q

Wierner prevalence in Asians

A

R1>R2>r=R0

81
Q

Most common partial D in CS

A

DVI

82
Q

Most common partial D in AA

A

DIIIa

83
Q

DEL

A

Asians with minute amount of D antigen

84
Q

Mur antigen

A

Hybrid MNS antigen in 10% of Chinese population

85
Q

GPA/GPA receptor for

A

P. falciparum

86
Q

Dolichos Biflorus agglutinates A1 as well as..

A

Sd(a)

87
Q

Le-a freq

A

22%

88
Q

Le-b freq

A

72%

89
Q

Lu-a freq

A

8%

90
Q

Lu-b freq

A

99.9%

91
Q

% AA Fy (a-b-)

A

68%

92
Q

% AA Le (a-b-)

A

22%

Blood Bank (14 decks)

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