Antibodies and such Flashcards
1
Q
Guinea pig urine
A
Sd(a)
2
Q
Hydatid cyst fluid
A
P1
3
Q
Saliva
A
H, Le(a)
4
Q
Breast milk
A
I
5
Q
Pigeon eggs
A
P1
6
Q
Plasma
A
Chido, Rodgers
7
Q
Dolichos biflorus
A
A1
8
Q
Bandeiraea simplicifolia
A
B
9
Q
Ulex europeus
A
H
10
Q
Lotus tetragonolobus
A
H
11
Q
Arachis hypogaea
A
T
12
Q
Vicea graminea
A
N
13
Q
Significant HTLAs
A
Cartwright (Yt(a)), Holley (Hy), Gregory (Gy)
14
Q
Insignificant HTLAs
A
Chido/Rodgers (Ch/Rg), Sd(a), Cs(a), Kn(a), York (Yk(a))
15
Q
Antigens enhanced by enzymes
A
AB, Le, I/i, P, Rh, Kidd
16
Q
Antigens decreased by enzymes
A
MNS, Fy(a), Fy(b), Luteran, Chido, Rodgers, Yt(a)
17
Q
Antigens unaffected by enzymes
A
Kell
18
Q
Frequency of D
A
85%
19
Q
Frequency of C
A
70%
20
Q
Frequency of c
A
80%
21
Q
Frequency of E
A
30%
22
Q
Frequency of e
A
98%
23
Q
Frequency of G (CD)
A
84%
24
Q
Frequency of f (ce)
A
65%
25
Frequency of K
10%
26
Frequency of Jk(a)
75%
27
Frequency of Jk(b)
75%
28
Frequency of Fy(a)
65%
29
Frequency of Fy(b)
83%
30
Frequency of M
80%
31
Frequency of N
72%
32
Frequency of S
55%
33
Frequency of s
90%
34
Frequency of U
99.9%
35
Frequency of P1
80%
36
Frequency of Jk(a-,b-)
rare, except in Pacific Islanders (1:400)
37
Frequency of Fy(a-,b-)
rare in whites, 68% in blacks
38
3 reasons that Rh+ patient with anti-D antibody
1. auto antibody with Rh specificity
2. Partial D with antibody
3. Alloantibody anti-LW (LW closely associated with D antigen, so may appear to be an anti-D antibody)
39
Noncovalent coating of RBCs with drug with which the patient has an antibody; dose dependent
Drug adsorption (hapten) mechanism
40
Type of hemolysis associated with Drug adsorption (hapetn) mechanism
extravascular hemolysis
41
Prototypic drugs of Drug adsorption (hapetn) mechanism
penicillin (3% have positive DAT, of which 5% have hemolysis)
42
Drug becomes adsorbed to the RBC membrane and subsequently becomes coated with antibody that can bind complement
Drug dependent antibody mechanism
43
Type of hemolysis of Drug dependent antibody mechanism
intravascular hemolysis
44
Prototypic drug of Drug dependent antibody mechanism
Piperacillin, cephalosporins
45
Drug induces red cell autoimmunity that persists after withdrawal of the agent (drug independent) - autoantibody directed against an innate component of red cell membrane and indistinguishable from those that cause idiopathic WAHA
Autoimmune induction mechanism
46
Prototypic drugs of Autoimmune induction mechanism
Methyldopa, levodopa, procainamide, fludarabine, 2nd and 3rd generation cephalosporins
47
Drug induced nonspecific, nonimmune, binding of immunoglobulin to the red cell surface; non specific adsorption of albumiin, IgG, IgA, IgM, and complement to RBC membrane, no antibody production (eluates are negative)
Nonimmune protein adsorption mechanism
48
Prototypic drug of Nonimmune protein adsorption mechanism
Cephalothin
49
Frequency of C(w)
2%
50
Frequency of V
1%
51
En(a) negative genotype
MN null
52
MkMk genotype
MNSs null
53
McLeod genotype
Kx null
54
All cells in panel and autocontrol positive at AHG only
warm autoantibody
55
All cells in pane, except autocontrol, positive at AHG only, weak (1+/2+)
HTLA
56
All cells in panel and autocontrol positive only at IS
cold autoantibody
57
All cells in panel and autocontrol positive at IS and 37C, not at AHG
antibody to reagents
58
IgG subtype that does not cross the placenta
IgG2
59
3 reasons for cord sample with positive DAT and negative maternal antibody screen
1. ABO HDN
2. RhIg
3. Low incidence antigen not on screen
60
antibody associated with renal dialysis
anti-Nf
61
antigen that is an epitope on band 3 protein
Diego (null phenotype cases HS, HE, acanthocytosis)
62
Epitope on glycophorin C; null phenotype is a cause of HE
Gerbich (Leach phenotype)
63
Clinically significant HTLAs
Cartwright (Yt), Holley (Hy), Gregory (Gy)
64
Low incidence antigens
Wr-a, Kp-a
65
Le(a)
CA19.9 epitope
66
Le(b)
Norwalk
67
O frequency in CS/AA
44/50
68
A frequency in CS/AA
40/25
69
B frequency in CS/AA
11/20
70
AB frequency in CS/AA
4/5
71
D frequency in CS/AA
85/92
72
Bga
HLA-B7
73
Bgb
HLA-B17
74
Bgc
HLA-A28/A2
75
Glycine Max
Tn
76
A3
mf agglutination
77
Le(a-b-) individuals at risk for
Candida and E. coli infections
78
Which population has a higher prevalence of i-adult phenotype
Asians
79
Le(b) receptor for (2)
H. pylori and Norwalk
80
Wierner prevalence in Asians
R1>R2>r=R0
81
Most common partial D in CS
DVI
82
Most common partial D in AA
DIIIa
83
DEL
Asians with minute amount of D antigen
84
Mur antigen
Hybrid MNS antigen in 10% of Chinese population
85
GPA/GPA receptor for
P. falciparum
86
Dolichos Biflorus agglutinates A1 as well as..
Sd(a)
87
Le-a freq
22%
88
Le-b freq
72%
89
Lu-a freq
8%
90
Lu-b freq
99.9%
91
% AA Fy (a-b-)
68%
92
% AA Le (a-b-)
22%
