MISCELLANEOUS ENZYMES Flashcards
5’ NUCLEOTIDASE (5’N) systematic name
Phosphoric Monoester Hydrolase
5’ NUCLEOTIDASE (5’N) predominantly secreted in the _____
LIVER
5’ NUCLEOTIDASE (5’N) is marker for ___ & ____ of the liver
hepatobiliary disease & infiltrative lesions
5’ NUCLEOTIDASE (5’N) is marker for ___ & ____ of the liver
hepatobiliary disease & infiltrative lesions
5’ NUCLEOTIDASE (5’N) reference value
0-1.6 units
Index of parenchymal function
CHOLINESTERASE/ PSEUDOCHOLINESTERASE
Monitors effect of muscle relaxants (succinylcholine) after surgery
CHOLINESTERASE/ PSEUDOCHOLINESTERASE
CHOLINESTERASE/ PSEUDOCHOLINESTERASE is used as marker for
insecticide/ pesticide/
poisoning (organophosphate component)
CHOLINESTERASE/ PSEUDOCHOLINESTERASE reference value
0.5-1.3 units in the plasma
ANGIOTENSIN-CONVERTING ENZYME (ACE) is also known as
Peptidyldipeptidase A or Kininase II
ANGIOTENSIN-CONVERTING ENZYME (ACE) is useful for converting _____ (inactive form) to ____ (active form) in the _____
Angiotensin I
Angiotensin II
LUNGS
ACE is also a possible indicator of neuronal dysfunction ______ important for the diagnosis of ____
dementia
Alzheimer’s
ACE is increased in
○ Sarcoidosis
○ Acute and chronic bronchitis
○ Leprosy
ANGIOTENSIN-CONVERTING ENZYME (ACE) main source
Macrophage & Epithelioid cells; found in the lungs
A copper-carrying protein which acts as an enzyme
CERULOPLASMIN
CERULOPLASMIN is marker for
Wilson’s Disease (hepatolenticular disease)
Ceruloplasmin is ___ in Wilson’ disease.
low
For hepatobiliary diseases.
ORNITHINE CARBAMOYL TRANSFERASE (OCT)
ORNITHINE CARBAMOYL TRANSFERASE (OCT) reference value
8-20 mU/mL
It functions to maintain NADPH in the reduced form in the erythrocytes.
GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD)
____ serves as a protective coenzyme
NADPH
A newborn screening marker
GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD)
GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) is found in
adrenal cortex, spleen, RBC, and lymph nodes.
DECREASED G-6-PD or Deficiency can lead to ________
drug-induced hemolytic anemia
ONLY enzyme that is significant when decreased
GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD)
GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) increased levels
- Myocardial infarction
- Megaloblastic anemia
G6PD specimen
- Red Cell Hemolysate
- Serum
G6PD reference value
10-15 U/g Hgb/1200-2000 mU/mL packed RBC
Liver Enzymes
Transaminases
Transpeptidase
Phosphatases
Miscellaneous
Transaminases
Transpeptidase
Phosphatases
Miscellaneous
Transaminases - ALT, AST
Transpeptidase - GGT
Phosphatases - ALP, ACP
Miscellaneous - 5’NT
CARDIAC ENZYMES
CK, AST, LDH
PANCREATIC ENZYMES
Amylase & Lipase
OTHER MISCELLANEOUS ENZYMES
Cholinesterase, ACE, Ceruloplasmin, OCT, & G-6-PD
