Miscellaneous Flashcards
Macrolide Adverse Effects
Hepatotoxicity
Qtc Interval
GI
Ototoxicity
erm Gene Resistance
Macrolide, cross to Clindamycin
Fluoroquinolones Adverse Effects
CNS: Headache, Dizziness CDAD (Ciprofloxacin most) Accumulation in bones, joint pain Phototoxicity Prolonged QTc Peripheral Neuropathy Tendonitis
Tetracycline Adverse Effects
CNS: Vestibular Dysfunction
A - Calcified tissues
Phototoxicity
Hepatic (elimination), Renal, GI problems too
Doxycycline and Minocycline LIVER elimination
Tetracycline RENAL
Meningitis
Vancomycin (S. Pneumonia)
Ceftriaxone (H. Influenza, N. Meningitis)
Ampicillin (L. Monocytogenes)
Clindamycin Targets and Exception
Anaerobic Gram Positive - NO CDAD
Cation Problems
TC, FQ, II
Inducers and Inhibitors
Inducers:
- Rifampicin
- SJW
- Carbamazepine, Phenytoin
Inhibitors:
- Ciprofloxacin
- Protease Inhibitor
- Macrolides minus azithromycin
- Azoles
- SSRI, Grapefruit Pomelo;
Cotrimoxazole first line for
UTI, cannot pseudomonas
E. Coli
Pneumocystis Pneumonia
Pseudomonad drugs
Piperacillin Carbapenems minus Ertapenem C3 - Ceftazidime C4 - Cefepime C5 - Ceftobiprole; Ceftaroline
Ciprofloxacin
Aminoglycosides; Aztreonam - Anaerobic Gram Negs
Random cannots: Tetracycline, Co-trimoxazole
Syphilis drugs
Pen G (IV), Tetracycline
Atypicals
Macrolides (Azithromycin + Ceftriaxone for N. Gonorrhea; Chlamydia )
Tetracycline
Fluoroquinolones (respi for M. Pneumonia, Ch. Pneumonia)
MRSA cannots
P C C, Ciprofloxacin cannot;
C5 can
CDAD causes and drugs
Clindamycin and Ciprofloxacin (FQ can)
Metronidazole and Oral Vancomycin
Metronidazole targets
CDAD, BV, Anaerobes (bites also can); Amoeba;
H. Pylori;
