Anesthetics and Analgesics

Question 1

General Anesthetics MOA

Answer 1

Ligand gated ion channel - GABA, Nicotinic, etc

Question 2

General Anesthetics Effects

Answer 2

CVS: CO decrease TPR decrease
Respi: Bronchodilation, depressant of muco-ciliary function, Respi depressant - poor reflex to hypercapnia

Kidney, Liver Blood flow decreases

Question 3

IV Anesthetics MOA and examples

Answer 3

GABA receptor agonist, open GABA-Gated ion channels

• Barbiturate
• Ketamine
• Propofol

Question 4

Local Anesthesia Chemical properties

Answer 4

Weak bases, inject w NaHCO3; effective in alkali tissues for uncharged form to pass through;

Question 5

Local Anesthesia MOA and SE

Answer 5

Nerves, CNS, Heart cells

• block Na Channel at intracellular end, limit depolarization, make cells less excitable
• Sleepiness, Seizure, Coma
• Decrease contractility, hypotension

Question 6

Narcotic Analgesics MOA and Examples

Answer 6

GPCR; Codeine, Morphine

If leak systemic has suppressive effects
CNS: cough suppression, sedation, respi depression
GI: constipation
CVS: BC, Hypotension