Miscellaneous

Question 1

where are these made?
ACh
DA
NE
5-HT

Answer 1

ACh- nucleus basal is of meynert
DA- VTA, substantia nigra
NE- locus ceruleus
5-HT- raphe nucleus

Question 2

4 DA pathways

Answer 2

mesocortical- negative sxs
mesolimbic- positive sxs
nigrostriatal- EPS (dystonia, akathisia, TD, NMS)
tuberoinfundibular- prolactin effects (galactorrhea, gynecomastia)

Question 3

5-HT receptors

Answer 3

5HT1a- locus of depressive sxs?
5HT2a,c- HA, jitteriness, decreased libido, insomnia
5HT3,4- GI sxs

Question 4

this APD is best for the (-) sxs of schizophrenia

Answer 4

clozaril

Question 5

MAOI increase ___________ in the brain

Answer 5

DA, NE, 5HT

Question 6

this mood stabilizer can cause a transient leukocytosis

Answer 6

Li

Question 7

this mood stabilizer causes craniofacial defects if used while pregnant

Answer 7

carbamazepine

Question 8

the LOT benzos only undergo ______

Answer 8

glucuronidation

Question 9

benzo from quick onset/short duration to long onset/longer duration

Answer 9

alprazolam –> lorazepam –> clonazepam

Question 10

CSF findings in AD patient

Answer 10

low amyloid beta and high p-tau

Question 11

complication of SSRI can be hyponatremia due to _____

Answer 11

SIADH

Question 12

thyroid function decreases with age (T/F)

Answer 12

F

outside of pathological changes

Question 13

“strongest” atypicals

Answer 13

olanzapine and risperidone

Question 14

these two atypicals are more sedating

this atypical is more activating

Answer 14

seroquel, zyprexa

abilify

Question 15

these TCAs are tertiary amines and are _____ (more/less) selective for serotonin

Answer 15

clomipramine, imipramine

more selective

Question 16

which SSRI do you not need to taper

Answer 16

fluoxetine

Question 17

SSRI- good for OCD, risk for fulminant hepatic failure

Answer 17

fluvoxamine

Question 18

in terms of SSRI causing sleep problems, ______ is most activating and _______ is least activating

Answer 18

prozac is most

paxil is least

Question 19

these TCAs are secondary amines and affect _____ (NT) the most

Answer 19

desipramine
nortriptyline
amoxapine
NE

Question 20

NRIs (norepinephrine reuptake inhibitors)

Answer 20

atomoxetine
reboxetine
-can cause tremor and tachycardia

Question 21

wellbutrin is (activating/sedating)

Answer 21

activating- don’t take it at bedtime

Question 22

these antidepressants affect 5-HT and NE

Answer 22

some TCAs (amitriptyline, trimipramine, protriptyline)
venlafaxine- HTN
duloxetine- HTN but good for neuropathic pain
mirtazapine- no sexual dysfunction, alpha2 antagonist, sedation and weight gain
nefazodone- no sexual dysfunction, liver tox!

Question 23

cortisol levels are ______ in MDD pts

MDD pts _____ (do/do not) suppress in the dex suppression test

Answer 23

high

do not

Question 24

imaging of MDD pts show hypo activity in the ______

Answer 24

prefrontal cortex

Question 25

drug tx for seasonal affective disorder

Answer 25

MAOI > SSRI

Question 26

adenosine antagonist

Answer 26

caffeine

Question 27

ADHD imaging findings

Answer 27

decreased volume of basal ganglia
hypoechogenicity of substantia nigra
decreased metabolism in the prefrontal cortex

Question 28

depression tx in kids and adolescents

Answer 28

kids- fluoxetine

adolescents- escitalopram

Question 29

OCPs and mood stabilizers

Answer 29

OCP and carbamazepine decrease lamictal levels
depakote increases lamictal levels
carbamazepine, oxcarbazepine decrease OCPs

Question 30

latuda is _____ (activating/sedating)

Answer 30

activating

-it can cause akathisia

Question 31

post partum psychosis often eventually manifests as _____ (bipolar disorder/depression)

Answer 31

bipolar disorder