Misc

Question 1

What type of drugs are clonidine, gaunabenz, gaunfacine, and methyldopa?

Answer 1

alpha2 agonists

Question 2

What is reserpine?

Answer 2

a NE storage depletion

Question 3

What is metyrosine?

Answer 3

a catecholamine storage depletor used to treat pheochromocytoma

Question 4

What benefits do alpha agonists have over beta blockers?

Answer 4

they can be used in asthmatics and diabetics. Have no reflex tachycardia because of vagal nerve effects. Most can be used in pregnancy (methyldopa)

Question 5

What are some negative effects of alpha agonists?

Answer 5

somnolence is most common. Dry mouth.

Question 6

Can an alpha agonist like methyldopa be used in a patient with pheocromocytoma?

Answer 6

no, it interferes with catecholamine quantitation

Question 7

Are ACE inhibitors and ARBs useful in pregnant women?

Answer 7

NO. they cause birth defects

Question 8

What is reserpine? What are its major toxicities?

Answer 8

long lasting catecholamine storage depletor. Inhibits VMAT2 (the vesicular transport). Has effects in both peripheral and central.
Can cause concentration problems and suicidal tendencies/depression.