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Misc Flashcards

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Dermatology Board Prep flashcards
1
Q

patients wth erythropoietic protoporphyria have a defect in

A

ferrochelatase

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2
Q

location of split in bullous pemphigoid, cicatricial pemphigoid, PCT, EBA

A

sub-epidermal

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3
Q

immunoflourescent patter in bullous pemphigoid and herpes gestationis

A

linear C3 with occasional IgG at basement membrane

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4
Q

atopic derm is Th*

A

Th2

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5
Q

the portion of the electromagnetic spectrum that products a particular biologic effect (e.g. erythema, delayed tanning)

A

action spectrum

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6
Q

wavelength of Wood’s light

A

365nm

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7
Q

how is actinic prurigo different from polymorphous light eruption?

A

AP lesions begin in childhood and remit in puberty, occur on all sunexposed areas and may occur on non-sun exposed areas, and may persist for months, and chelitis is frequently seen

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8
Q

Topical and systemic agents that produce phototoxicity and/or photoallergy usually have action spectra in what range?

A

UVA

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9
Q

Patients with an allergy to the compositae family may have an allergic reaction to which family of drugs?

A

Pyrethrins, insecticidal

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10
Q

mosquitos that cause malaria

A

Anopheles

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11
Q

Mosquitos that cause yellow fever

A

Aedes

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12
Q

Mosquitos that cause dengue

A

Aedes

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13
Q

Capsaicin works by ***ing substance P release

A

increasing, leading to depletion

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14
Q

leading cause of necrotic arachnidism in several states of the Pacific Northwest

A

Tegenaria agrestis (hobo spider)

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15
Q

The necrosis and hemolysis that can result from a brown recluse spider bite may be attributed to which of the following toxins?

A

sphingomyelinase D

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16
Q

Organ transplant recipients are at risk for developing many cutaneous tumors. The risk of melanoma is ***-fold that of the general population whereas these patients have a xxx-fold increased risk of developing squamous cell carcinoma.

A

***3

xxx65

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17
Q

What is the tattoo pigment responsible for most lichenoid reactions?

A

mercuric sulfide

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18
Q

laser used for rhinophyma

A

carbon dioxide

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19
Q

10,600 nm laser

A

carbon dioxide

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20
Q

Which of the following histochemical stains can be used intraoperatively during Mohs micrographic surgery to confirm the diagnosis of extramammary Paget’s disease?

A

cytokeratin 7

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21
Q

This medication is the drug of choice for erythema nodosum leprosum. It inhibits tumor necrosis factor-alpha and suppresses monocyte and neutrophil phagocytosis.

A

thalidomide

22
Q

most photosensitizing tetracycline

A

demeclocycline

23
Q

a chimeric anti-epidermal growth factor receptor antibody that is FDA approved to treat advanced colorectal cancer. Acneiform eruptions have been reported to occur in up to 1/3 of patients.

A

cetuximab

24
Q

What is the most common cause of nonpigmented fixed drug eruption?

A

pseudoephedrine

25
Q

Fibrofolliculomas are associated with

A

Birt-Hogg-Dube syndrome

26
Q

On electron microscopy, which cell demonstrates cytoplasmic projections and secretory granules

A

Mast cell

27
Q

MOA of ipilimumab

A

inhibitor of CTLA-4 (normally inhibit T-cell activation)

28
Q

Acid keratins (K10-20) are expressed on what chromosomes?

A

17

29
Q

basic keratins expressed on what chromosomes?

A

12

30
Q

Major protein component of the cornified cell envelope

A

Loricrin

31
Q

protein that is cross-linked by transglutaminase in the granular layer to form insoluble cell boundary

A

Involucrin

32
Q

Protein that links cell envelope to desmosomes and keratin filamnets

A

Envoplakin

33
Q

protein that promotes aggregation and disulfide bonding of keratine filaments in cell envelope

A

Filaggrin

34
Q

T cell subset in Sezary syndrome

A

CD4+/CD7-

35
Q

***syndrome is the leukiemia phase of MF

A

Sezary

36
Q

most common autoimmune disorder in pts with chronic hep C

A

autoimmune thyroiditis

37
Q

most common sunscreen ingrediant to cause photoallergic CD

A

oxybenzone

38
Q

Rituximab targets

A

CD20 antigen

39
Q

CD20 antigen is expressed on what cells

A

T cells

40
Q

SPINK5 mutation

A

netherton’s syndrome

41
Q

SLURP1 mutation

A

Mal de Maleda

42
Q

GJB2 mutation

A

VohWinkels syndrome

43
Q

LMX1B mutation

A

Nail-Patella syndrome

44
Q

CYLD mutation

A

Familial Cylindromiasis

45
Q

syndrome: ichthyosis linearis circumflexa, trichorrhexis invaginata, atopic derm, food allergy

A

Netherton’ssyndrome

46
Q

tooth finding in tuberous sclerosis

A

enamal pits

47
Q

genodermatosis associated with BCC

A

Gorlin Syndrome

48
Q

mutation in PTCH gene

A

Gorlin syndrome

49
Q

folliculin mutation

A

Birt Hogg Dube

50
Q

PRKAR1A mutation

A

Carney

51
Q

PTEN mutation

A

Cowden and Bannayan-Zonana

Misc Derm (4 decks)

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