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Misc Derm > Ch56 > Flashcards

Ch56 Flashcards

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Dermatology Board Prep flashcards
1
Q

epidermal layer K5,14

A

basal

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2
Q

epidermal layer K1,10

A

Spinous - lamellar granules

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3
Q

epidermal layer k2,11

A

granular - loricrin

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4
Q

epidermal layer 15

A

bulge cells

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5
Q

body site k1,9

A

suprabasal palmoplantar

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6
Q

body site K6,16,17

A

palmoplantar, nail, nair, adnexal

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7
Q

body site 4,13

A

mucosa

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8
Q

body site k3,12

A

cornea

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9
Q

k20

A

merkel cell

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10
Q

k80,86

A

hair

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11
Q

k19

A

stem cells

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12
Q

Acidic keratins are type * and K* found on chromosome ***

A

type 1
K9-20
Chr17

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13
Q

Basic keratins are type * and K* found on chromosome ***

A

type 2
K1-8
Chr12

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14
Q

Name type III keratins

A

vimentin, desmin, periperin, GFAP

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15
Q

name type V keratin

A

Lamin

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16
Q

adhesive points between cells

A

desmosomes

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17
Q

As a response to an injury the *** cells may migrate out to form new epidermis

A

bulge

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18
Q

caused by loss of TG1

A

lamellar ichthyosis and CIE

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19
Q

Most important part of gene is *** which are crucial for filament elongation

A

helix initiation/ termination motifs

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20
Q

hair or skin? K9-28

A

skin

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21
Q

hair or skin? K31-40

A

hair

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22
Q

hair or skin? K1-8

A

skin

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23
Q

hair or skin? K71-86

A

hair

24
Q

*** is crucial to epidermal differentiation

A

p63

25
Q

p63 maintains *** expression & represses cell cycle inhibitors

A

K5,14

26
Q

K1 expression & cessation of cell cycling are regulated by 2 genes:

A

p63 isoform deltaNp63a and Notch

27
Q

*** crucial to inducing differentiation (increases from basal to cornified layers)

A

Calcium

28
Q

CE:cross linking of keratin and fillagrin by

A

loricrin

29
Q

enzyme of proliferative activity in the basal layer

A

ornithine decarboxylase

30
Q

ornithine decarboxylase is stimulated by

A

trauma, UV, estrogen, EGF, beta agonists, tumor promoters

31
Q

ornithine decarboxylase is inhibited by

A

retinoids, steroids, protein deprivation

32
Q

what keratins found in transitional boundaries of basal layer

A

K5/14 and k19

33
Q

Keratin filaments insert into *** and attached to the BM

A

desmosomes and hemidesmosomes

34
Q

***% of basal cells are stem cells

A

10%

35
Q

Ceraminds found in which layer?

A

spinous layer

36
Q

in spinous layer, what keratins are synthesized

A

K1,10

37
Q

what keratins found in AKs, psoriasis, wound healing

A

K6,16

38
Q

keratins of hyperproliferative states in spinous layer

A

K6, 16, Ki67, intergrin

39
Q

lamellar granules diseases

A

Harlequin fetus and X-inked ichthyosis, CIE

40
Q

*** bonds in TG makes CE insoluble

A

gamma glutamyl lysine isopeptide

41
Q

Psoriasis: ** Involucrin, ** loricrin/fillagrin

A

Psoriasis: high Involucrin, low loricrin/fillagrin

42
Q

TG***:lamellar ichthyosis, non-bulbous CIE

A

TG1

43
Q

TG***: fetal epidermis

A

tg2

44
Q

TG***:cross links the CE (Ca dependent), hair, DH

A

TG3

45
Q

disease of Hypogranulosis:

A

Ichthyosis vulgaris

46
Q

disease of hypergranulosis:

A

Lamellar ichthyosis, Psoriasis

47
Q

corneal layer forms when ** is converted to **

A

forms when profillagrin converted to fillagrin

48
Q

profillagrin conversion is dependent on

A

calcium

49
Q

fillagrin degrades into

A

urocanic acid (UV block(

50
Q

corneal layer has *** bonds that act like glue

A

disulfide

51
Q

bricks of corneal layer

A

protein rich corneocytes

52
Q

mortar of corneal layer

A

loricrin and lamellar lipid rich ECM

53
Q

granular layer water barrier

A

adherens junctions

54
Q

adherens junctions made of

A

E(verywhere) and P (basal) cadherins

55
Q

protein of adherens junctions

A

armadillo

56
Q

tight junctions

A

zolula occludens

Misc Derm (4 decks)

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