misc Flashcards
who is crcl usually overestimated in
elderly over 65, malnourished, low muscle mass
what p value is stat sig
less than 0.05
formula for relative risk
it happened to in exp group/total in that group all divided by the same in the control/placebo group
formula for RRR
1-RR
formula for absolute risk reduction
arithmetic difference between event rates in groups ie control group event rate - exp group event rate. *if increased risk, this is the ARI (NNH is calculated from this)
formula for NNT
100/ARR. NNH is same but use ARI (absolute risk increase)
what is the NNH
number of patients who would have to be treated for one person to experience an adverse event
what is the NNT
number of patients who would have to be treated with the intervention for one to benefit
what does confidence interval indicate
precision of estimate- confidence that x% of the values overlap with the true value. Wide CI mean less precise
what does a smaller p value mean
less likely result is due to chance
which ace inhibitor’s absorption is decreased by food
captopril
when to hold an ace arb unless just volume depletion
30% increase in SCr or K over 5.6
can ace and arbs be used in black patients
don’t work as well but can be for compelling indications
what is aliskirin
direct renin inhibitor
which beta blockers have ISA activity
pindolol, acebutalol
which BB need to be adjusted in kidney failure
all cardioselective except metoprolol, plus pindolol and nadalol
which BB have alpha and beta blockade
carvediol, labetalol
first line HTN in preg
methyldopa
name alpha blockers, what are they used for
doxazocin, terazocin, prazocin. HTN, pheochromocytoma, prostatism
chemo; platinums
cisplatin (very emetogenic), carboplatin, oxalyplatinin (cold sensitivity). all can cause nephro and otto***
chemo; taxanes
used in breast cancer and prostate; paclitaxil, docitaxil., less emetogenic, most arthralgias and myalgias
doxorubicin-cancer
cardiotoxic
bleomycin-cancer
lung toxic
irenotecan-cancer
diarrhea-will use a lot of loperamide
nibs+fluorouracil- cancer
can cause hand and foot irritation/rash/dryness. avoid tight shoes or callous causing things, good foot care, keep moisturized
epithelial growth factor receptor drugs,-cancer
cause rash (many nibs, cetuximab)
trastuzumab
her2drug
filgrastim
bone pain
small molecule kinase inhibitors
NIBs (cancer)
anthracyclines (rubicins)
cardiotoxic
nibs, liposomal doxorubicin, flurouracil, capacitabine
hand foot skin reactions
