misc Flashcards

1
Q

who is crcl usually overestimated in

A

elderly over 65, malnourished, low muscle mass

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2
Q

what p value is stat sig

A

less than 0.05

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3
Q

formula for relative risk

A

it happened to in exp group/total in that group all divided by the same in the control/placebo group

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4
Q

formula for RRR

A

1-RR

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5
Q

formula for absolute risk reduction

A

arithmetic difference between event rates in groups ie control group event rate - exp group event rate. *if increased risk, this is the ARI (NNH is calculated from this)

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6
Q

formula for NNT

A

100/ARR. NNH is same but use ARI (absolute risk increase)

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7
Q

what is the NNH

A

number of patients who would have to be treated for one person to experience an adverse event

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8
Q

what is the NNT

A

number of patients who would have to be treated with the intervention for one to benefit

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9
Q

what does confidence interval indicate

A

precision of estimate- confidence that x% of the values overlap with the true value. Wide CI mean less precise

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10
Q

what does a smaller p value mean

A

less likely result is due to chance

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11
Q

which ace inhibitor’s absorption is decreased by food

A

captopril

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12
Q

when to hold an ace arb unless just volume depletion

A

30% increase in SCr or K over 5.6

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13
Q

can ace and arbs be used in black patients

A

don’t work as well but can be for compelling indications

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14
Q

what is aliskirin

A

direct renin inhibitor

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15
Q

which beta blockers have ISA activity

A

pindolol, acebutalol

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16
Q

which BB need to be adjusted in kidney failure

A

all cardioselective except metoprolol, plus pindolol and nadalol

17
Q

which BB have alpha and beta blockade

A

carvediol, labetalol

18
Q

first line HTN in preg

A

methyldopa

19
Q

name alpha blockers, what are they used for

A

doxazocin, terazocin, prazocin. HTN, pheochromocytoma, prostatism

20
Q

chemo; platinums

A

cisplatin (very emetogenic), carboplatin, oxalyplatinin (cold sensitivity). all can cause nephro and otto***

21
Q

chemo; taxanes

A

used in breast cancer and prostate; paclitaxil, docitaxil., less emetogenic, most arthralgias and myalgias

22
Q

doxorubicin-cancer

A

cardiotoxic

23
Q

bleomycin-cancer

A

lung toxic

24
Q

irenotecan-cancer

A

diarrhea-will use a lot of loperamide

25
nibs+fluorouracil- cancer
can cause hand and foot irritation/rash/dryness. avoid tight shoes or callous causing things, good foot care, keep moisturized
26
epithelial growth factor receptor drugs,-cancer
cause rash (many nibs, cetuximab)
27
trastuzumab
her2drug
28
filgrastim
bone pain
29
small molecule kinase inhibitors
NIBs (cancer)
30
anthracyclines (rubicins)
cardiotoxic
31
nibs, liposomal doxorubicin, flurouracil, capacitabine
hand foot skin reactions