misc Flashcards
1
Q
erythema multiforme
A
necrotic keratinocytes spongiosis, basal vacuolar changes, subepidermal blister dermal edema perivascular lymphocytes extravasated RBC
2
Q
sweets syndrome
A
epidermal necrotic keratinocytes dermal edema diffuse dermal infiltrate of neutrophils lymphocytes, histiocytes few, eosinophils extravasated RBC vasculitis present/absent
3
Q
LCV
A
epidermis nromal /necrotic/vesicles/pustules vasculitis small venules predominant neut, e/l/histio nuclear dust RBC extravasation, thrombi
4
Q
DIF LCV
A
IgG/M/complement/fibrin( splash pattern)
granular pattern
superficial blood vessels
5
Q
PAN
A
- epidermis normal/necrotic/ulcerated
- leukocytoclasticvasculitis of arteries( small/medium)- deep dermis/subQ fat
- intimal proliferation/thrombi
- fibrosis older lesions
6
Q
PAN systemic complications
A
brain, heart
kidney, abdominal arteriits/aneurysms
death
7
Q
PAN cuaneous lesions
A
urticarial, purpura, painful red nodules
livedo reticularis, digital infarct
8
Q
PAN underlying systemic disease
A
- hep B/C
- cryoglobinemia
- ANCA autoab
9
Q
Epidermal nevus
A
Hyperkeratosis, papillomatosis, acanthosis, sometimes hypergranulosis ▪ Epidermolytic hyperkeratosis rarely (11.1) ▪ Acantholytic dyskeratosis rarely (11.3) ▪ Perivascular lymphocytes often
10
Q
Epidermal nevus genetics
A
post-zygotic somatic mosaicism
mutations in FGFR3 gene or PIK3CA gene
