MISC Flashcards

1
Q

BP

A

GEN POP: > 18 screening 2 yearly.
MOD RISK: 6-12 monthly
HIGH RISK: 6-12 weekly
EXISTING : 6 monthly.

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2
Q

CHOL

A

GEN POP: > 45, 5 yearly.
ATSI : > 35
LOW RISK: 5 yearly
MOD RISK: 2 yearly
HIGH/EXISTING: 6 monthly-12 monthly

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3
Q

DM

  • Dx > 7 fast BSL;
  • Dx > 11.1 Random BSL;
  • Dx >6.5 HBA1c,
  • Dx >7 + 11 OGTT
  • 2 occasions
A

SCREEN w AUSDRISK: 3 yrly > 40, ATSI > 18.

HIGHER RISK : FASTING BSL/HBA1c 3 yearly
= >40 w obesity,
AUSDRISK > 12,
first degree relatievs w DM,
high risk race,
CVA/CVD,
women w GDM, (but normal OGTT post partum)
women w PCOS,
anti-psychotics

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4
Q

CKD

A

screen only if high risk: BP, ACR, eGFR 1-2 yearly.
= smoking,
BMI > 30
FHx CKD
DM
HTN
ATSI > 30
CVD/CHD/PVD
history AKI.

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5
Q

Impaired OGTT/fasting BSL/preDM

Impaired:
HBa1c 6-6.4–> repeat 1 year.
fasting BSL 5.5-6.9 –> OGTT

A

12 monthly fasting glu/HBA1c

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6
Q

OGTT NON PREGNANT

A

OGTT:
1) < 7.8 at 2 hours, but impaired fasting = IFG.
then retest in 1 year.
2) < 7 fasting, but >7.8- 11 2 hour = IGT .
then retest 1 year.
3) >7 + >11 = DM.

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7
Q

GDM

A

RF: previous GDM, hyperglycaemia; previously elevated BSL, hx IGT, > 40, ATSI, FHx DM in primary relatives/sister w GDM, prepregnancy obesity > 30, fetal macrosomia in previous pregnancy, PCOS, use of drugs causing hyperglyceamia.

High risk = test 12 weeks; otherwise 24-28 per guidelines

no HBA1c Dx, > 5.5% –> OGTT

GDM Dx at > 12 weeks
criteria:
fasting BSL >5.5
2 hour > 8
(can also have DM in pregnancy, > 7 fasting, >11 2 hour / random).

repeat OGTT 6-12 weeks post partum.

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8
Q

Behavioural modification

A
- ask, advise, asses, assist, arrange f/u 
# precontemplation: GP to raise doubt and increase patient preception of risk and problems w current behaviour. 
# contemplative: weigh up pro/con of change w the patien and work on helping tip balance: 
 - exploring ambivalence, alternative. 
- identify reasons or chagne/risks of not changing 
- increase confidence w ability to change. 
# preparation: goal setting, SMART 
#maintenance: identify and use strategies to prevent relapse 
# relapse: renew process of contemplation and action without demoralisation.
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9
Q

PCV

A

GEN POP:

  • >70 should receive prev13.
  • or at tiem fo diagnosis w at risk condition (asplenia, immunosupp, lung path).
  • otherwise child = x 3.

ATSI
- < 5yo = x 4 + pneumo23 at 4.
- >50, prev13
+ 12 mo later pneumo23 + 2nd 23 at 5yr

Catch up
1) Previous 23 dose.
• 1 dose of prev13 12mo after last 23 dose
- … only need 2 lifetime adult doses of pneumo23.
2) no previous pneumo 23 dose
- prev 13 asap, then pneumo23 + also give another 23, so total 2 doses – but needs to be at least 5 years after the previous 23, and at least 12 months post prevenar13
• Can given 2-12 months later if needed between 13 and 23.

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10
Q

smoking cessation

A

ax readiness to quit
use the scale – how much to do you want to quit? how much do you think you will be able to quit?
ax nicotiene dependence (>10/day, craving/withdrawls, < 30 mins from waking).
ask about past experiences/concerns.
SMART goal

non pharma

  • behavioural support w regular appts
  • counselling: Quitline
  • cbt: deep breathe, drink water, do somethign else.
  • best evidence: behavioural support + pharmacotherapy.

NRT
10/day = 21, > 10 = use also lozenger/gums.
1 x 12 week course on pbs; more for atsi/ctg
caution w post CVasc event. pregnancy try cold turkey first then rx.

varenicline: champix
12 weeks, starter pack + then contuing pack
dream/nausea/constipaton ; reduce w renal impairement.
can do up to 24 weeks on PBS and not smoking by 12.

nortriptyline

bupropion

  • not w pregnancy, seizures, MAOI or EDs.
  • reduce etOH required.
  • 9 week course; caution w concurrent SSRI use
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11
Q

etOH

A

1) all about 6 months, need support, CBT, regular review, trusted supply
A) disulfiram 100mg OD
- cannot drink! bad reaction, inc. seizures/flushing/cvasc/autonomic,r elated to malabsorption
- need to be generally fit and well
B) acamprosate 666mg, 333mid + nocte
- really excreted
- not in acute periods of w/drawl
C) naltrexone
- not good for opiate concurrent use
- reduced pleasurable FX so good for binge drinking
- LFT monitoring pre/post.

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12
Q

glaucoma - chronic

A

IOP > 22
peripheral vision loss, usually has a FHx, usually incidental finding and open angle.
RF” advancing age, FHx, african descent, previous trauma, short sightedenss (myopia), systemic HTN, long term steroid use.

screening : > 40 = 2-5 yearly screening. if FHx then from 30 yo.

timolol BD. vs. latoprost OD. vs. OT

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13
Q

glaucoma - acute

A

IOP > 22
acute red eye w peripheral field loss, severe haeadche, photophobia, sometimes halos around lights
age > 60. fhx of same. female. myopia.

ED
opiaiod/antiemetic to stop vomitting
if ophthalm not available immediately: timolol drops; and acetazolamide/manniotrl

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14
Q
A
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15
Q

cataract

A

Sx vary depending on degree/site.

main cause of monocular diplopia, can also get halos around lights.

Cause: age, DM, smoking, steroids, RTx, TORCH, trauma, uveitis, dystrophia myotonic, galctosaemia.

OE: reduced red refelx, reduced VA, normal direct pupillary light reflex.

Prevent: sunglasses. control RF as above

Rx: ophthalm

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16
Q

NIPT

A

> 10/40 to about 14/40

about $350

cell free DNA + trisomy 21, 18, 12 + turners/kleinferlters + geneder

about 98-99% sensitivity

if negative, 1: 20 000 trisomy change, if positive –> almost diagnostic.

but its screening, rare, but there are flase negatives –> amnio/cvs.

also need to repeat uss , for morph.

takes 2 weeks for results

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17
Q

CFTS

A

9-13+6/40

trismony 13 (patau , 1st week, intel/birth), 18 (edwards - fatal pre birth/within first yr), 21.

85%-90% detection rate.

if high risk –> amnio/cvs. (1:20 will ahve pos diagnostic, otherws will be negative).

so screen positive rate is about 5% (NIPT 0.1%)

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18
Q

cocp adjustment

A
  • nausea = reduce oestrogen, take at night, change to LARC, exclude pregnancy
  • breast tenderness= reduce O/P, change P. consider alt. cocp : yasmin/yas
  • bloating: reduced O. change P (yasmin/yas)
  • headache : reduce O and or P change.
  • dysmenorrhoea: skips sugar pills, increase/change P.
  • decreased lipido: no evidence one type will change this over another
  • BTB: increase O (to 30mcg/35mcg); change P type if already on 35. try alt.
  • depression: not well linked, consider changing P
  • weight loss: not well inked.

good for acne: yas, yasmin, diane/brenda/juliette (all the same)

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19
Q

Fibromyalgia

A
  • non inflammatory MSK pain + fatigue, cognitive clouding, sleep changes
    • not diurnal, constant pain
  • RF: women, 40-50, anxiety history (IBS/headaches/urinary frequency)
  • OE:
    • pain on both sides, UL and LL, axial skeleton.
    • tender digital palpation at > 11/18 specific sites.
  • Ix: no specific – exclude alt w autoimmune screen.
  • Mx:
    • reassurance re: no inflammatory – not doing damage.
    • ‘oversensitised alarm’ going off for pain –> need to ‘muffle’ it
    • goal = manage pain, not remove it. improve QL
    • ex phys, increase coping, CBT, goodsleep, educate family.
    • can trial
      • endep
      • dulox 30-120
      • pregab 25-75
        *
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20
Q

Perma +

A
  • Positive emotion:
    • What have you gotten through, what makes you happy, what makes you smile
  • Engaement
    • Hobby/distraction/routine
  • Releationship
    • Who supports you/cares about you
  • Meaning
    • What gives you a sense of purpose
  • Achievement
    • What are you proud of? What have you gotten through?
  • +
    • Diet
    • Exercise,
    • Smoking
    • alcohol
    • sleep
  • sleep
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21
Q

FM non pharma

A
  1. reassurance
  2. graded eerobic exercise program to improve fatigue/pain
  3. reduce situational stressors./ CBT coping strategies
  4. good sleep practices
  5. family education
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22
Q

chronic fatigue

A
  • controversial diagnosis
  • persisting fatigue with variet of somatic + cognitive symptoms
  • diagnosis: presence of unexlpained persistent or relapsing fatigue,
    • 6/12.
    • not attributable to exertion.
    • with significant functional impairmeent
    • must be at leat 4 / 8
      • post exertional amalaise alsting > 24 housr
      • unfreshing sleep
      • impaired memory or cocnentration
      • muscle pain
      • joint pain without swelling/erythema
      • headache of new type/severity
      • tender cervical/axillary LN
      • sore throat.
  • peak incidence 20-40 yo. women > men.
  • ?post viral, altered immune function, neuropsych, enviro toxins/imms reactions all theoretical causes. no firm evidence fo any of these.
  • difficult prognostication.
  • Mx: MDT input
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23
Q

nephritic syndrome

A
  1. moderate to severe HTN
  2. haematuria
  3. GFR reduction usually mod/severe

due to

  • post stre GP
  • can be AKI (or nephrotic)
  • IGA nephropathy (happens while you have the sore throat!)
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24
Q

Nephrotic syndrome

A
  • cause:
    • minimal change GN(most common cause)
    • secondary: SLE / Dm / drugs
  • BP mildly increased or normal
  • normal/mild reduction to GFR
  • proteinuria
    • ​( >3.5g/day)
  • hypoalbuminaemia
  • oedema (facial)
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25
Q

bladder

A
  • overactive = nocturia, increased urgency, consider oxybutynin. but a diagnosis of exclusion
  • interstitial cystitis = cystological Dx; discomfort w bladder filling meaning they PU more often, only thing to relive that feeling
  • incontinence
    • stress - pelvic physio, weight loss.
    • urge - same as for stress –> old more each time. consider pessary/oxybutynin for urge.
    • mixed
  • remember for all: fluid/caffine intake, smoking, oestrogen status, obesity. relation to intercourse (interstitial)
  • remember for incontience: med SFX: alpha adrenergic, antidept, ccb, antihistmaine = sfx.
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26
Q

scrotal lump

A
  • hydrocele - painless, gradual increase in size.
  • epidydimal cyst - all ages, common, usuaully pea sized at top of teste, Rx w OT. benign
  • varicocele - swelling of vein about teste. starts after puberty. can affect fertility. Rx w OT
  • spermatocele - benign. contain sperm/sperm like cells. usually connected to teste.
  • hydatdi of morgagni - lump / cyst at top of teste, movable.only painful if they twist. dont need Rx unless twist/Sx
  • epidydmitis - obvious. STI.
  • orchitis - obvious, dont forget mumps/rubella
  • torsion - obvious.
  • undescended teste - bloc off LHS inuignal + touch w R, should reach down to the bottom of scrotum, without pressure - then when you release shoudl pop back up. wait for 3/12 if palpable –> dont uss, then uss if still not there and refer.

remember undescended teste can also (ontop of interfility) cause cancer RF.

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27
Q

Hearing loss

A

conductve = bone > air

sensory = air + bone both reduced

mild = 20-40 (background noise issue)

mod = 40-60 (miss most convo, child = poor pronunciation)

severe = 60-90 (wont hear most speech, child = =delayed speech )

age related = mild/mod high frequency snhl both ears

uniltaeral SNHL = always think ddx acousitc neuroma

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28
Q

nsaids general

A
  • naproxen 250-500 BD safest for Cvasc (Cox 1). (MR will increase GIT build up)
  • diclofenax 25 - 50 BD/TDS (non selective) = safer for GIT but higher CVasc risk so avoid here. .
  • cox 2 = better for GIT, try to avoid w Cvasc
    • celexocib (100-200mg, OD to BD)
    • meloxican (7.5-15mg, OD).
  • most unsafe for cvasc = meloxican 15mg.

potentially can use fish oil - but in ghigh qquantities of tablets, up to 3 capsules OD.

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29
Q

PMR

A

morning stiffness >45 mins. hip girdle dicomfort. bilateral shoulder. proximal weakness. no other joints. > 2 weeks usually

pain improves post shower/activity.

Dx: Sx, raised ESR/CRP, rapid response to pred 15mg OD (BIRD CRITERIA).

+ negative RF/CCP

Mx: reduce pred down by 2.5 every 4-8 weeks. educate: long course; monthly blood initially. relapse common. gentle tapering required.

associated GCA- you know this. OE: bitermporal artery tenderness/pulselessness.

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30
Q

rotator cuff

A
  • passive ROM non painful (Frozen shoulder it is).
  • movement loss identified by stressing tendons w isometric movements.
  • DO NOT USS to diagnose. (even if uss an astympatmoic shoulder, would see a rotator cuff issue). no XR either.
  • 1/4 improve by 1 month; 50% within 3 months. will progress over time likely; rotator cuff atrhrotpahty –> OA GH.
  • Mx: rest, warmth
    • range of motion and strengthenning with physio.
    • simple oral analgesia
    • consider s/acromial c/steroid injection for rapid pain relief w SA bursitis.
  • 3/12 not improved: surg review.
31
Q

repeat dislocations

A
  • watch for bankhart lesion (GH fracture) + humeral head # (hill sach lesion).

= if repeated dislocations/instability then OT for athroscopy + repair.

32
Q

thoracic outlet syndrome

A
  • compression of n/vasc structures coursing from neck to axillae through outlet
  • often 1st rib compression
    • and anterior scalene + upper border of first rib
  • RF: overhead athelte, poor posutre w dropping shoulders, congenital, # clavicle, psyueodarhtorsis, malunion fo clavicular fracture
  • get mixed Sx
    • arterial/venous/nerve.
      • localised pain
      • numbness/tingling in entire upper limb
      • arm feels weak/fatigued
      • venous engorgement.
  • OE: can have no signs.
  • special tests:
    • adsons test (lateral neck rotation + head extended , w arm abducted and breathe in- lose radial pulse)
    • roo test - hands up, open close for 1-3 mins + reproduces Sx.
  • Mx:
    • physio: correction of shoulderspostural/body mechanics.
      • surg consult and treatment if neurogenic symptoms not responding to physio. / if vasc compromise/thrombus
33
Q

hawkins kennedy

beer can

elbow in, flexed, push against me trying to int rotate

full extension of shoulder, try to push forwards into flexion

A

1) positive (int rotation), with subacromial impingement
2) positive , with supraspinatus pathology.
3) infraspinatus
4) biceps

34
Q

golfers

tennis

A

flexor = medial epi.

pain w resistance to flexion./pronation

extensor = lateral

pain w resistenace to extension/supination.

Mx:

graduated exercise program w physio - progressive loading increase

stretch out the flexor (for tennis)/extensor (for golfer)

strapping/band : limited evidence 10cm below joint

correct predisoposing factors

return to exercise gradaully.

physio.

35
Q

ulnar nerve entrapment syndrome

A

posteromedial elbow pain. sensory Sx like pins/needs in ulnar/ulnar forearm. tender to tap around medial epi.

cause: progressive weight training/repetitve stress, recurrent subluxation of nerve due to trauma/stress, irregular ulnar groove, traction injury

Dx: nerve conduciotn studies

Mx: surgeon/neurologist. consider OT

36
Q

RA signs/Sx

A

Hx

  • fhx inflam arthritis (mostly wrist/MCJP/PIPJ/MTPJ)
  • early morning stiffness > 1 hour
  • swelling > 5 joints
  • symmetrical
  • bilatearl compression tenderness to MTJP
  • > 6 weeks

OE:

  • z deformity of thumbs
  • ulnar devisiton
  • swan neck deformities
  • sometimes nodules on elbows.

DX:

  • bony erosions on XR, RF / Anti CCP, ESR/CRP, or rhematuoid notdules. can also have seronegative disease.
37
Q

RA mx

A

prognosis = proportional to CCP.RF titres, chronically elevated inflam markers, > 20 joints swollen, or impaired function in early disease/erosions on XR + smoking.

Mx:

  • pharma
    • urgent referral for urgent starting DMARDS - to try to aviod irreversible joint damage.
    • nsaid/fish oil if in remossion.
  • non pharma
    • regular aerobic exercise, and anaerobic to prevent muscle wasting/weight bearing.
    • no specific diet - but eat healthy
    • stop smoking
    • MDT: inc. using arthritis australia, pain management.
    • self Mx for early exacerbations once in remission.
  • manage associated conditions
    • atherosclerosis, OP, vasculitis, depression, lung disease, neuropathy
    • optimise immune status given immunosuppressed.
38
Q

gamers thumb mx

A

OE: ulnar stlyoid on table, ulnar deviation - shoudl cause pain on the radial side –> if not then pull down +/- flex thumb in = dx. + tender MT1

  • Rx:
  • c/steroid injection
  • splint for 6 weeks
  • nsaid.
  • stretching w OT. and grauated strengthenning. pen build up for work
39
Q

carpel tunnel

A
  • median (1, 2, 3, radial 4)
  • RF: pregnancy, DM, RA, hypothyroid, overuse of forearms.
  • wake at night w paraesthetsia/pain.
  • OE: tinel (tap) positive; phallen (60 sec) positive.
  • Dx: USS, nerve conduction studies (to exclue C6 radiculopathy).

Mx:

  • 1/3 spontensouly resolve.
  • other 2/3: Rx medical condition; nsaid, c/steroid injection , splinting/hand brace short relief, noctural elevation on pillow. OT definitive
40
Q

lateral hip pain

A
  • greater trocnhanter pain syndrome = pain at GT, trendeleberg gait, pain on hip abd. (hurts to lie on that side)
  • glute medius tendonitis = pain between GT and iliac crest, pain at outside of hip , pain w legs crossed. (worse w movement/getting out of car)
    ddx: labral tear, OA, GT impingement, NOF, SA, synovitis. rim lesion. lumbar radiculopathy (SUFE, pethes)

both more common in older women – menopause does affect tendon health, more disposed to microteras.

41
Q

osteitis pubis

A

women who has suddenly gone back to gym. classical presentation.

OE: tender pubis. adductor stress pos (squeeze fist w knees), and bring in hips against resistance: pain to osteitis pubis.

CT +/- bone scan/MRI (ddx stress fracture)

Mx:

conservative, supervised ex program w strengethenning adductors. pelvic floor. gradual return to work.

42
Q

obturator nerve entrapment

A

medial thigh pain/sensory changes. starts out as proximal groin pain on exercise.

OE: extension or lateral leg movement increase pain

RF: rbugy/afl. ddx intrapelvic mass lesion : CT.

Dx: nerve conduction tests

P: physio, consider surgical release.

43
Q

knee pain

A
    • child: osgood shlater - conservative mx, clinially: lump
    • ITBS: tender 2-3 cm above lateral joint line (ober test). conservative mx inc. dry needling/massage
    • meniscus: tender joint line; pos mcmurry/apley grind
    • patellar tendonitis (jumpers knee). tender at inferior patella /anterior knee–> tender w quad traction/tensing/cant squat : uss to diagnose. Physio.
  • patellofemoral syndrome - anterio knee pain, older. stairs/squat aggrevate. XR to exclude sinister (tuour/oa) but CLINICAL Dx– physio. bracing w patellar stabilisation. rest. taping, ice/analgesia. foot orthoresis to ralign.
  • prepatellar bursitis - housemaids knee. worry re: infective –> PO Abx/ortho. can inject w hlca.
  • gout/pseudogout (calcium / haemachromatosis/loo diuretics). joint aspiration: calcium crystals in fluid.
44
Q

bakers cyst

A
  • posteriomedial painful swollen mass at joint line
  • end of knee flexion can be restricted/squat.
  • uss can show, but not intraarticular structures (which are mostly the cause in adults)
  • mri usually the gold standard.
  • Mx:
  • child: resolves
  • Adutl: almost always communicates w knee joint – secondary to intraarticualr pathology. can aspirate + reinject HCLA/surg if very painful
45
Q

osteochondritis dissecans

A

child/adolescet.

pain/swelling at joint, brough on by sports.

can be knee/elbow/ankle.

Dx w XR

sometimes heals alone, if severe then can separate and float around –> OT

46
Q

peroneal nerve entrapment

A

foot drop.

numbness/tingling/pain w drop.

sensation: front + side o leg, top of feet.

herniated lumbar disk/knee fracture/replacement/tumour / cyst compressing nerve, ALS/MS/PD related

OE; cant pick up toe/DF ankle. disting gait w knee is raised high

Dx: nerve conduction

P: surgical repair/splint

47
Q

cervical radiculopathy

A
  • radiating arm pain, corresponding to a dermatomal pattern
      • neck pain, paraesthesia, muscle weakness in myotomal pattern, relfex impariement, headaches, scapular pain.
  • amplified by side flexion towards the side of pain + when an extension or rotation of th eneck takes place .
    • (spurlings test: neck extended, head rotated - downward pressure applied on head; positive if pain radiates to limb in ipsilatearl side.
  • cause : spondlyosis, disc herniation less common - more likely in younger patients.
  • mx
    • settles over time mostly.
    • icing in acute phase
    • nsaids
    • reduce nerve compressive forces: manual tass/avoid osutring.
    • wait 6-8 weeks. if not improved then MRI. +/- HLCA/laminectomy.
    • remember: can also trial lyrica - low dose, 25-50mg nocte. increase from there.
48
Q

ank spond

A
    • morning stiffness
    • loss of lordosis
    • increased kyphosis
    • months duration
      • have associated sacroilitis + axial spine pain
  • Ix: HLAB27 assocaited. can also have CRP?ESR high. seronegative spondlyoarthropty
    • XR: can show fusion/bamboo sign if severe.
    • if pos HLAB27/history pos, and negeative XR w strong sucpion: MRI.
  • OE: pain to SIJ/axial spine; modified schober test (reduced lumbar flexion), occiput to wall distance, chest expansion can be abnormal if progressive
  • Mx: NSAID, physio. if refractory: DMARD. stop smoking.
  • long term exercise program.
49
Q

enteropathic arthritis

A
  • IBD.
  • often axial spine/achilles/plantar fasc/sacroilitis
    • if peripehral, oligoarticular and asymmetrical, mainly in LL
50
Q

JIA

A
  • joint pain/inflammation
  • < 16 yo
  • recurrent
  • > 6 weeks duration
  • Types
    • RF pos (likely RA)
    • RF neg (more common, asymmetrical)
    • entehsitis related (boys, HLAB27 pos usually w fhx ank spond)
    • sysetmic:
      • fever, aslmon pink rash, lymphoadenopathy, polyserosisitis, arthritis.
  • Mx specialist for rx
    • non pharma GP:
    • GPMP for allied heatlhf unding
    • consider imapct life/self/moods/social
    • consider financial burden to parents + contrcaeption w methotrexate
    • need paed rheum involved
    • dont smoke
    • imms up to date.
    • nsaids PRN.
    • specialist: injectable steroids.
51
Q

pagets

A

ALP elevated

pagetic lesions on XR

sometimes asymptoamtic initially.

Rx: bisphosphonates.

52
Q

raynauds

A

primary: without CTD
secondary: with CTD.

fingesr/toes bilatearl vasopasms. can get ulcers.

Mx:

gloves. avoid cold. dont smoke. avoid touchign cold. trial vasodilators if BP OK. topical nitrate gels.

53
Q

RF

A

suspect in any child w fever, joint pain, new movements disorder

particularly in ednemic/ATSI/hx of preceeding GAS

Dx: Jones criteria

Mx: can try PO phhenoxymethylpenicllin BD for 10 days but need v strict adherence

empirical benzathine pencilling G, repeat 1.2 million units, every 21028 days for 10 years after most recetn ep; or until 21. sometimes up to 40 is severe.

dental health important.

54
Q

scleroderma

A

finger discomfort, arthralia, GORD = scleroderma.

1) morphea - skin only, often kids w no systemic features; sabre strokes (can be over joint/deeper so atch).
2) CREST

  • calcinosis, raynauds, esophageal dysmotility, sclerodactyl, telangiectasia.
  • pulmoanry HTN fiboriss, renal compromise.

3) diffuse sysetmic disease / systemic sclerosis
* can be mild/skin only + can go into rapid progression to renal crisis/htn crisis.

puts pt at higher cvasc risk *so does SLE - atherosclerosis!

55
Q

Sjrojens

A

Sicca without CTD/RA.

dry eyes, dry mouth, arthritis.

ENA Ro/La positive. chrimers test (tears). + inflam markers, ana pos.

non pharma: avoid smoking, avoid dry/heated air, consider TCA/anticholindergis, good hydration, biotene /eye drops, vagina lubricant. artificial tears. dental checks.

56
Q

antidept.

A
  • 1) escitaloparm 20mg, start at 10mg, review in 2-4 weks to increase by 5mg up to 20mg. (less libido SFX)
  • 2) fluoxetine 20mg. start slowly. weight neutral.
  • 3) sertraline 50mg up to 100mg. ‘safe’ for pregnancy.
  • mirtazepine 7.5-15mg nocte, increase to 30mg after a few days if tolerating. 2-4 week review
  • SNRI: duloxetine 30mg, then 60mg. after 2-5 weeks.
  • agomelatine expensive and only for teratmet resistance
  • TCA: endep 25-75mg nocte. psychiatrist involvement.
57
Q
A
58
Q

ED

A
  • common
    • causes: organic, psychosocial combined.
    • meds” BBlockers, antidep, anticholinergic, thc, narcotics, etOH, antihsitamines.
  • OE: look for plaques/peyronies/hypospadia/tesicular atrophy (or size < 4mL + kilnefelter )
    • look for cvasc system inc. wcc < 94cm. carotid bruits.
    • look for peripheral neuropathy
  • Ix: DM, hypogonadism, cvsc disease.
  • Rx
    • mod RF modification:
      • smoking cessation, reduce etOH, improve diet, weight loss, stress reduction, illicit drug cessation. compliance w cvsac meds
    • PDE5 inhibitors - try 8 times prior to saying it doesnt work. sfx: GIT, myalgia, headace, flushing, cvasc/lower BP w other nitrates. no amyl
59
Q

Premature ejcaulation

A
  • no clear medical cause - often a psychological problem.
  • hx: primary vs. secondary; intravaginal ejaculatory latency time, previous sexual function, hx of relationships, percieved degree of control. is fertility an issue?
  • trauma/prostatitis/hyperthyroid/meds/psych history
  • taboo/belief improtant.
  • if painful - need DRE/prostatisi work up.
  • manage cause:
    • behavioural technique: stop/start, extended foreplay, preintercourse masturbation, cognitive distractions, alternative positions, interval sex, increase frequency.
    • SSRI / sertraline 50mg.
    • secondary: consider PDE5 inhib to continue erection post ejaculation.
    • CBT
    • local anaesthetic spray.
60
Q

male infertility

(kleinfelters: small tesicular volumne < 4mL, taller than average, reduced facial hair, reduced body hair, breast development, feminine fat distribution. (see androgen def w 2 low level morning tesoterones, LH and FSH both elevated, and see karyotype 47 xx. )

A
  • > 12 month twice/week uprotected vaginal intercourse.
  • look for:
    • etste atrophy (androgen def)
    • undescended teste history
    • psychosexua issues
    • past STI hx
    • androgen use.
    • ?having sex at fertile times.
    • female history.
    • lifestyle: diet, exercise, alcohol, smoking cessation.
    • pubertal developmental history.
    • inguinal/genital/pelvic surg history
    • meds/etOH
  • OE:
    • scrotal/testicular exam. testicular volume (15-35mL). penile exam; seconary sex characteristis. if concerns re prostatic Sx: prostate exam. cvasc risk exam.
  • Ix: semen analysis.
    • then: FSH, LH, total testosterone. PRL.
    • tesiticular USS
  • FSH high = seprmatogenesis is poor (primary testicular hafilure).
  • low testsoterone/high LH: androgen def.
61
Q

androgen def

A

tesicular 1’ = chromosomal (kleinefelters), undescended testes, trauma, infections (mumps orchitis), HCT< thallassaemia, myotonic dystrophy, meds/surg procedures e.g. spiro/ketoconazole/ctx.

hypothalamic/pituitary 2’ : hypogonotrophic hypogonadism, pituitary micro/macro adenoma, pituitary trauma/disease, meds/surg.

OE:

pre pubertal: micropenis, small testes.

peripubertal: delayed/incomplete sexual matruation, small testes, abnormal penile enlargment/pigmentation of scortum, laryngeal development, growth of facial hair/body hair, muscle development/gynaecomastia
postpubertal: regression of virilisation. mood changes, lowl ibido, letahrgy, hot flushes. reduced growth/facial/body hair, low semen volume. low BMD.

Ix: LH, FSH, serum tesosterone. (PRL, iron, anti pit function, karyotyping if suspecting kleinefelter, MRI brain).

Rx: TRT. (injectable, patch, gel, cream, oral BD to TDS)

DONT GIVE: if prostate/breast cancer. or hct > 55%.) relative c/i: Hct > 50%, untreaetd OSA, severe LUTS, or BPH, advanced CCF.

62
Q

hyperparathyroidism

A
  • commonly benign. rarely cancerous.
  • RF: women>men. Post menopausal, lithium, neck irradiation.
  • Sx: bones, stones, psychic moans.
    • mostly asymptoamtic and find w high Ca2+/fractures
    • can cause fatigue, weakness, LOA, abdo pain, mood changes.
    • constipation w high Ca2+.
  • primary hyperPTH: high with high Ca2+. (or normal w elevated Ca2+)
  • secondary: low calciums tates: CKD, vit D Def, GI malabsorption.

Ix: - urinary calcium/creatninie ratio. (LOW if familial hypocalciuric hypercalcaemia); NORMAL in hyperparathyroidism).

complications: renal impairement, renal calculi.

P: endo refer. watch for renal caucli, OP. avoid diuretics. avoid dehydration/prolonged bed rest. ensure adquate vit D.

63
Q

secondary hypertension: (OSA/non compliance)

A
  • primary hyperaldosteronism (conns syndrome) = aldosterone secreting adenoma
    • Sx: HTN, hypokalaemia, aldsoterone excess, supressed plasma ernin activity
    • screen: plasma aldosterone: renin ratio - if elevated –> specialist.
      • specialist will go on to do a plasma aldosterone + 24 hour urinary aldosterone/sodium/creatining level w specialist advise.
  • cushing syndrome (see separately):
    • screening: 1 mg dex suppresion test.
    • or measure free late night salivary cortisol/24 hour urine cortisol
  • phaeochromocytoma:
    • screening: 24 hour urinary metanephrines.
    • if Sx: plasma metanephrines.
64
Q

cushings

A
  • OE:
    • facial puffiness/moon faecies
    • central obesity
    • thinning of skin
    • wekness , proximal.
    • easy bruising
    • bufalloe hump
    • moon faceies
    • facial plethroa
    • hirsutism
    • menstrual distrubances
    • psychiatric/mood disorders
    • pityriasis versicolour
  • complicated by DM, HTN, hyoperhcol, OP.
  • child: growth failure, delaeyd matruation.
65
Q

hyperclcaemia of malignancy

A

mostly lung/breast/prostate/blood/renal.

Sx: polydipsia, severe constipation, confusion, increased pain/malaise/fatigue/anorexia.

always think in palliative pts w these Sx

Rx:

establish goals of care

stop thiazide diuretics, vit D/calcium.

ED if wanting actiev treatment, CoCA > 4 –> seizure/arrythmia risk.

66
Q

addisons def

A

primary adrenal insuf.

usually autoimmune.

Sx:

  • coritsol def: fatigue, anorexia, weight loss. postural hypotnesion
  • excess ACTH; skin pigmentation from melanin production/suntanned/somtimes buccal hyperpigmentation
  • aldosterone def: hyponatremia, hyperkalaemia, acidosis, tachycardia, hypotnesion, low volate ECG, postural hypotnesion, salt cravings.

Ix:

  • hyperkalaemia
  • hyponatremia
  • positive short synacthen test.
  • elevate ACTH.
  • elevated plasma renin

Mx: specialist

if unwell: pulse hydrocort. fludricort always as baseilne.

regular BMD 2 yearly, also check coealiac/thyroid/t1dm/pernicious anaemia.

67
Q
A
68
Q

hyponatremia

A

depends on fluid status, you know the Sx

  • euvolemic (fluid restrict mildly, fix cause), only Rx if severe Sx w CNS involvement - hypertonic saline
    • SIADH (illness/maligancy, or drugs - ssri; or cerebral path for too much ADH)
    • hypohtyroid
    • adrenal insuf
    • pscyhogenic
  • hypervolaemia
    • ccf/cirrhosis/ckd/nephritic syndrome
  • hypovoaemia (NSaline, stop drugs taht might cause).
    • accelerated losses w free water intake
    • thiazide diuretics
    • sodium wasting states
    • primary adrenal insuf
  • psuedo: hyperglyaemaic. hypertrigliceridaemia.
69
Q

ARR

A

risk of outcome in control group - risk of outcome in treatment group = absolute difference in rates of events between th two groups. giving us the idea of basleine risk and treatment effect.

ARR = 0 = no difference.

ARR 0.05 = 5% reduction in the event.

= CER - EER.

NNT = 1/ARR

70
Q

RR

A

RR = hwo many times more likely it is that an ecvent will occur in the treatement group relatie to the control group.

RR = 1 means no difference, RR < 1 = treatement decreases the risk of the outcome.

RR> 1 meanas treatment increases the risk.

RR = risk of outcome in the treatment group / risk of oucome in the control croup

71
Q

RRR

A

relative risk reduction = complement of RR (1-RR).

tells us the reduction in the rate of the outcome in the treatment group, relative to that of the control group.

72
Q

NNT = 1/ARR.

A
73
Q

e.g. 15% of the control group died and 10% of the treatment group died at 2 years. . what is the NNT/ARR/RR/RRR

A
  1. RR = risk of outcome treatement / risk of outcome in control
    1. 0.1/0.15 = 0.67... which means the treatment reduces the risk of death as RR < 1. (when > 1 = increased risk of the outcome).
  2. ARR = 15%-10% = 0.15-0.1=-.05= absolute benefit of treatement is a 5% reduction in death rate.. if arr = 0 then no difference.
  3. NNT but need to treat 20 people for 1 to benefit (NNT =1/0.05=20 = 1/ARR)
  4. RRR = 1-RR = 0.33 = the treatment reduced the risk of death by 33% relative to that occuring in the control group.

So if the COCP increaes the clotting risk from population 5: 10 000 to 12: 10 000, in absolute terms has only gone up 5 / 10 000… but in relatiev terms

0.0012/0.0005=2.4 = doubles the risk of the outcome comapred to the treatement group = rr

Arr = 0.0005-0.0012= -0.0007

= so slightly less risk in the control group… but still very low risk overall.

74
Q

sen spec

A