Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Blood Bank: 1st Sem > Minor Blood Groups > Flashcards

Minor Blood Groups Flashcards

1
Q

epitope for an anti-Duffy monoclonal antibody that blocks P.vivax binding

A

Anti-Fy6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

increased expression of Lutheran antigens on reticulocytes is associated with

A

sickle cell vaso-occlusive crises

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

overexpression of this antigen is associated with ovarian carcinoma

A

Lu glycoprotein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

this antigens has high affinity receptor for laminin

A

Lutheran antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Immunoglobulin type of Anti-Lub

A

IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Immunoglobulin type of Anti-Lua

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

antigens of this blood group is located on two RBC membrane glycoproteins

A

Lutheran blood group

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

associated with HIV susceptibility

A

Fy null

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

associated with benign ethnic neutropenia

A

Fy null

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

this antibody is produced by sickle cell

A

anti-Fy3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Anti-Fya and Anti-Fyb: what type of immunoglobulin?

A

IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

blood phenotype associated to resistance to Plasmodium knowlesi and P.vivax

A

Fy(a-b-)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

common Kidd phenotype among Polynesians

A

Jk(a-b-)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

strongly associated with delayed HTRS with intravascular hemolysis

A

Kidd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

well developed antigens on neonatal RBCs but is rarely respinsible for severe HDFN since it is non immunogenic

A

Jka and Jkb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

this bacteria converts K– cells to K+ cells

A

Streptococcus faecium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

this antibody suppresses fetal erythropoiesis

A

Anti-kell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

the absence of this antigen is associated with decreased blood pressure

A

Kell antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Kell antibody associated with delayed and immediate HTRs and HDFN

A

Anti-K1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

absence of XK protein on RBCs and weak expression of K Kpb and Jsb

A

McLeod phenotype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

null phenotype of KELL

A

KoKo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

antigens of this blood group is not destroyed by enzymes but by disulphide-bind reducing agents

A

Kell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

blood group found in chromosome 7

A

Kell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

associated to resistance to P.falciparum (in vitro)

A

En(a-) and U-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
receptor of babesia and adheres to RBC sialic acid (P.falciparum)
GYPA AND GYPB
26
IgG in nature; binds complement and causes severe HTRs with hemoglobinuria and HDFN
Anti-S and Anti-s
27
cold reactive IgM/IgG and found in dialysis patients with equipment sterilized with formaldehyde
Anti-N
28
antibody that do not bind complement, ph dependent (what ph?), common in children, and glucose dependent
Anti-M (IgM); ph (6.5)
29
phenotype of individuals with recombination and loss of glycophorin B leading to altered expression of antigen
S-s-U- phenotype
30
Null phenotype of MNSs blood group
U-, Mk, En(a-)
31
Ss antigens differs in what amino acid position?
position 29
32
Ss antigens are found in what cell structure?
GYPB
33
MN antigens are found in what structure of a cell?
GYPA
34
MN antigens are easily destroyed by what enzymes
ZZAP, DDT, papain, ficin, trypsin, and pronase
35
True or False. MN antigens are well developed at birth
True
36
MN antigens are antithetical antigens which differs in what amino acid positions
position 1& 5
37
MNSs blood group system found in what chromosome?
Chromosome 4
38
overexpressed in metastatic breast cancer, prostate, and colon cancer
GCNT2
39
has a protective role against HDFN-ABO
Ii antigens
40
antibody formed in the transition state of i into I
anti-IT
41
this antibody is also in patients with WAIHA and Hodgkin's disease
Anti-IT
42
this I blood group antibody reacts strongly with cord RBCs
Anti-IT
43
anti-IT is commonly found among
Melanesians and Yanomami Indians
44
associated with infectious mononucleosis and lymphoproliferative disorders
auto anti-i
45
associated with primary atypical pneumonia (Mycoplasma pneumoniae)
Pathogenic auto anti-I
46
associated with CAIHA (Cold Agglutinin Syndrome)
Pathogenic Autoanti-I
47
this antigen also has H specificity and reacts stronger with group O and A2 RBCs
Anti-I and anti-i
48
I blood group antigens are resistant to what enzymes?
DTT and glycine-acid EDTA
49
Anti-I is enhanced by what enzymes?
Ficin and papain
50
what immunoglobulin type is Anti-I?
IgM
51
a rare autosomal-recessive phenotype associated with congenital cataracts
i adult phenotype
52
this antigen is elevated in HEMPAS
i antigen (but I antigen expression is unaffected)
53
both antigen I and i can be neutralized by:
Milk
54
marker for embryonic and mesenchymal stem cells
LKE
55
receptors for P-fimbriated uropathogenic E.coli
P, Pk, LKE
56
receptors for shiga toxin
Pk
57
antibody associated with Paroxysmal cold hemoglobinuria
Anti-P (Donath-Landsteiner antibody)
58
antibody found in the serum of Pk and P individuals
Alloanti-P
59
antibodies formed in patient with E.granulosus and fascioliasis
strong anti-P1
60
antigen associated with resistance to parvovirus B19
P1 and Pk antigens
61
immunoglobulin type of anti-P1
IgM (detected by IAT) and reacts at 37*C (also causes immediate and delayed HTRs)
62
Pk antigen is present in all RBCs except in what phenotype?
p null phenotype
63
P blood group antigens are poorly developed at birth and it will take how many years?
7 years
64
P blood group antigens are resistant to what enzymes?
ficin, papain, DDT, CHLOROQUINE, and glycine-acid EDTA
65
form of P1 in RBCs
glycosphingolipid
66
antigen found in hydatic cysts
P1 and Pk
67
antibody found first in patient with stomach carcinoma
Anti-PP1Pk
68
associated with spontaneous abortion and HDFN
Anti-PP1Pk
69
blood group antigen associated with HIV resistance
Pk
70
marker for Burkitt's lymphoma
Pk (CD77)
71
P1 structure
Lactosylceramide —N-acetylglucosamine—galactose—galactose
72
common precursor of P blood group antigens
lactosylceramide
73
Pk antigen structure:
ceramide—glucose—galactose—GALACTOSE
74
P2 blood group is composed of what antigen/s?
Pk antigen
75
P1 blood group is composed of what antigens?
P1 and Pk antigen
76
null phenotype of P blood group
p
77
has epitope for tumor marker CA 19-9 or gastrointestinal malignancy
sialyl-Lea
78
Blood group ohenotype which increases risk of atherosclerotic and coronary death
Le(a-b-)
79
when will Le(a+b+) be converted to Le(a-b+)?
6 years
80
Lewis glycolipids are present in the plasma___days after birth.
10 days after birth
81
why someone with Le(a-b+) fails to produce an Anti-Lea?
Because small amounts if unconverted Lea antigen are still in the plasma and saliva
82
form of Lewis antigens present in the RBCs
glycolipids
83
Leb structure:
R—N-acetylgalactosamine—Galactose (Fucose attached both to N-acetylgalactosamine and galactose)
84
Lea structure:
R—N-acetylgalactosamine—Galactose (Fucose attached to N-acetylgalactosamine)
85
what type of precursor chain present in Lewis blood group?
Type 1 precursor
86
which is stronger: anti-Lea or anti-Leb?
Anti-Lea
87
percentage of secretors in the population?
80%
88
Lewis antibodies is freq. present in the serum of a pregnant woman with what phenotype?
Le(a-b-)
89
what immunoglobulin is the Lewis antibodies?
IgM (both anti-Lea and anti-Leb)
90
Act as receptor for Helicobacter pylori
Leb antigen
91
Lewis antigens are resistant to what enzymes
ficin, papain, DTT, glycine-acid EDTA (however, Ab reactivity is enhanced by these enzymes)
92
Lewis phenotype common in Africans
Le(a-b-)
93
Lewis phenotype common in 10-40% of Asians
Le(a+b+)
94
Lewis phenotype of ABH secretors
Le(a-b+)
95
Lewis phenotype of ABH non-secretors
Le(a+b-)
96
chromosome of Se gene
Chromosome 19
97
chromosome of Lewis gene
Chromosome 19
98
two genes responsible for the fucosyltransferases leading to Lea and Leb formation
Le and Se genes
99
True or False. Lewis antigens are produced by RBCs.
False. it is produced by other tissues and is passively absorbed in the RBCs
100
form of lewis antigen in lymphocytes, platelets and other tissues
glycoproteins

Blood Bank: 1st Sem (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions