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IMHM > MINOR BLOOD GROUPS > Flashcards

MINOR BLOOD GROUPS Flashcards

1
Q

Enumerate systems respectively

010
011
012
013
014
015

A

Diego
Yt [cartwright]
Xg
Scianna
Dombrock
Colton

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2
Q

010

System:
Chromosomes:
Ag location:

A

Diego
17
Band 3 [RBC Ae1/Soluble Carrier Family 4 Ae1]

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3
Q

rare in most population, but is polymorphic in people of Mongoloid ancestry

A

Dia

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4
Q

010
Antigens

A

Dia/Dib
Wra/Wrb
Wru/DISK +16

22 ANTIGENS
3 sets of high/low prevalence of [a,b,a,b] pairs

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5
Q

Dia/Dib POLYMORPHISM location

A

last 7th extracellular loop of the protein

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6
Q

011

System:
Chromosomes:
Ag location:

A

Cartwright/Yt
7q22
[amino acid substitution] glycosylphosphatidylinositol [GPI]

acetylcholinestrase [ACE]

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7
Q

function of Diego System’s Ag location

A

integral transport protein for anion exchange of bicarbonate for chloride.

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8
Q

function of Yt System’s Ag location

A

GPI– linked RBC glycoprotein

ACE– neurotransmission + RBC bound role NOT KNOWN.

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9
Q

011
Antigens

+Phenotype

A

Yta/Ytb

Phenotype:
Common: Yt[a+,b-] Yt[a+,b+]
Rare: Yt[a-,b+]

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10
Q

012

System:
Chromosome:
Antigens:

A

Xg
X

XgA [X antithetical partner]
CD99

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11
Q

Xg antigens prevalence by gender

A

Female: HIGH [89%]
Male: LOW [66%]

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12
Q

013

System:
Chromosomes:
Ag location:

A

Scianna
1p34.2
Erythroid Membrane Associated Protein [ERMAP]

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13
Q

ERMAP

function:
system:

A

for adhesion
Scianna

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14
Q

014

System:
Chromosomes:
Ag location:

A

Dombrock /Do
12
mono-ADP-ribosyltransferase

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15
Q

mono-ADP-ribosyltransferase

function:
system:

A

attached to RBC membrane
by GPI anchor.

Dombrock/ Do

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16
Q

015:

System:
Chromosomes:
Ag location:

A

Colton [Co]
7p14
integral membrane protein aquaporin 1

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17
Q

integral membrane protein aquaporin 1

function:
system:

A

80% water reabsorption in the kidney

Colton

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18
Q

Elaborate Colton’s ANTIGENS + their prevalence

A

Coa= HIGH
Cob= LOW [10%]
Co3= [+]ALL RBCs except those of the very rare phenotype Co[a-, b-]
Co4: HIGH in 2 individuals w/ Co[a-,b-] phenotype.

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19
Q

017:

System:
Chromosomes:
Ag location:

A

Chido/Rogers [Ch/Rg]
6
2 closely-linked genes [C4A/C4B]

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20
Q

system associated with HLA

A

Chido/Rogers
[017]

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21
Q

017 Antigens

A

6 CH
2 RG
WH

22
Q

C4a and C4b as location to CH/Rg’s Ag

function

A

products:
C4d FRAGMENTS – C4A [Rodgers]
C4 COMPLEMENT COMPONENTS– C4B [CHIDO]

23
Q

020:

System:
Chromosomes:
Ag location:

A

Gerbich
2
glycophorine C/D [GPC/GPD]

24
Q

glycophorine C/D [GPC/GPD]

structure:

A

Sialo-glycoprotein structure

25
Q

020 ANTIGENS

A

6 HIGH PREVALENCE AG
Ge2, Ge3, Ge4,
GePL, GeAT, GeTI

5 LOW PREVALENCE AG
Wb, Lsa, Ana, Dha
GEIS

26
Q

020 Phenotypes

A

3: RBCS LACK 1 or more of HIGH PREVALENCE AG [2,3,4]

Yus: Ge:-2,3,4
Gerbich: -2,-3,4
Leach: -2,-3,-4

27
Q

RBC morphological abnormality present in a system, indicate specifically

A

Elliptocyte in Gerbich Phenotype – Leach [Ge: -2,-3-,4]

Gerbich 020

28
Q

021:

System:
Chromosomes:
Ag location:

A

DAF/CD55

29
Q

prevalent in black individuals

A

CROMER 021

30
Q

system involved in the regulation of complement activation

in what way?

A

021 [Cromer]

accelerates the decay of C3/C5 convertertase

31
Q

CROMER in DAF/CD55 is

Resistant: [2]
Destroyed: [1] [explain]

A

ficin, papain

a-chymotrypsin
used to distinguish specificities in the system from other blood group system

32
Q

022:

System:
Chromosomes:
Ag location:

A

KNOPS [KN]
1
CR1

33
Q

022 KNOP’S Antigens + Phenotype

A

9 AG
Helgeson phenotype

34
Q

_____represents the serologic null phenotype for a the ___ blood group.

A

Helgeson phenotype
Knops

35
Q

023:

System:
Chromosomes:
Ag location:

A

INDIAN [IN]
11p13
hematopoietic isoform of CD44 marker

36
Q

023
Ag location’s function

A

immune adhesion properties

37
Q

024

System:
Chromosomes:
Ag location:

A

OK
19
CD147

38
Q

CD147 function as location in OK system 024

A

receptor and adhesion molecules

39
Q

023
ANTIGENS

A

5 AG
2 Antithetical AG: Ina, Inb

40
Q

024
ANTIGENS

A

OKGV
OKVM

41
Q

system that is well-developed on RBCs from newborn

A

OK system 024

42
Q

025

System:
Chromosomes:
Ag location:

A

RAPH
11
CD151

43
Q

a tetraspanin which appears to be essential for the basement membrane’s assembly in the kidney/skin

A

CD151

44
Q

026

System:
Chromosomes:
Ag location:

A

John Milton Hagen [JMH]
15
GPI-linked glycoprotein CD108

45
Q

028

System:
Chromosomes:
Ag location:

A

GILL
9
glycerol transporter AQP3

46
Q

glycerol transporter aquaporin 3 in Gill’s System [028] FUNCTION

A

a major intrinsic protein family of WATER CHANNELS

47
Q

030

System:
Chromosomes:
Ag location:

A
48
Q

028 ANTIGENS

A

GIL antigen

49
Q

030 ANTIGENS

A

RHAG1 [Duclos/ 901013]
RHAG2 [Ola/ 700043]

50
Q

A newest blood group system that is essential for Rh antigen expression.

[DOES/DOES NOT] HAVE RH BLOOD GROUP AG

A

RHAG 030

51
Q

what do we call the absence of RHAG due to mutation

A

Rh null phenotype

IMHM (4 decks)

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