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33 Adrenal steroids & related drugs > Mineralocorticoid > Flashcards

Mineralocorticoid Flashcards

1
Q

Mineralocorticoid (1 drug)

A

Fludrocortisone

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2
Q

Fludrocortisone - MOA

A

Na reabsorption coupled (loosely) with K+ and H+ excretion. Binds to mineralocorticoid receptors in cytoplasm causing increased expression of Na/K-ATPase and epithelial sodium channels.

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3
Q

Mineralocorticoids - adverse effects

A

Hypokalemia
Metabolic alkalosis
Increased plasma volume
Hypertension

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4
Q

Fludrocortisone - indications

A

Adrenocortical insufficiency (primary addison)
Adrenectomy - replacement therapy
CAH (combo with hydrocortisone)

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5
Q

Fludrocortisone and hydrocortisone are combined in the treatment of …

A

CAH

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33 Adrenal steroids & related drugs (4 decks)

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