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33 Adrenal steroids & related drugs > Glucocorticoids - general > Flashcards

Glucocorticoids - general Flashcards

1
Q

Glucocorticoids - MOA

A

1) Inhibit interleukins and NF-κB (no activation of T cells).
2) Suppress cytokine synthesis in helper T cells.
3) Inhibits release of infl mediators
4) Stabilization of lysosomes in neutrophils
5) Vasoconstriction and decreased capillary permeability
6) Decrease macrophage activation
7) Suppression of lymphoid tissue, reduced circulating lymphocytes
8) Increase levels of RBCs, platelets, PMNs.

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2
Q

Glucocorticoids - indicated for which autoimmune disorders? (6 disorders)

A 
SLE
Autoimmune thrombocytopenia purpura
Polyarteritis nodosa
Multiple sclerosis
Ulcerative colitis
Polymyositis
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3
Q

Glucocorticoids are indicated for which types of cancers?

A

Lymphocytic leukemias

Lymphomas

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4
Q

Glucocorticoids are indicated for which dermatologic disorders (5 diseases)

A 
Atopic dermatitis
Seborrheic dermatitis
Pruritus 
Psoriasis 
Sunburn
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5
Q

Glucocorticoids - indications (excluding autoimmune, dermatologic disorders and cancers)

A 
Adrenal insufficiency
Neonatal respiratory distress syndrome
Hypercalcemia
Sarcoidosis (DOC), RA
Prevention of organ transplant rejection
Keratitis and ocular infections
Asthma and allergic rhinitis
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6
Q

Pt on glucocorticoids - what should be monitored?

A 
Osteoporosis
Hidden infections
Gastric ulcers
Hyperglycemia and glucose intolerance.
Hypokalemia.
Blood pressure
Edema
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7
Q

Glucocorticoids - contraindications (8 diseases)

A 
Peptic ulcers
Heart disease
High BP
Infections (varicella, TB)
Psychoses
Diabetes
Osteoporosis
Glaucoma
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8
Q

Glucocorticoids - adverse effects (except those that should be monitored for)

A

Decreased growth in children, myopathy, salt retention, iatrogenic Cushing syndrome
Psychosis, insomnia
Diabetes

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9
Q

Too rapid termination of glucocorticoid treatment can cause

A

Adrenal insufficiency

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10
Q

Ohphthalmic cortisol preparations (2 drugs)

A

Loteprednol

Difluprednate

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11
Q

Loteprednol - indications

A

Corneal inflammation

Keratitis

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12
Q

Difluprednate - indications

A

Ocular surgery (for pain and inflammation

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13
Q

Low-potency topical cortisol (3 drugs)

A

Desonide
Hydrocortisone
Dexamethasone

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14
Q

Medium-potency topical cortisol (2 drugs)

A

Triamcinolone

Fluticasone

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15
Q

High-potency topical cortisol (2 drugs)

A

Desoximehtasone

Fluocinonide

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16
Q

Very-high-potency topical cortisol (2 drugs)

A

Clobetasol

Bethamethasone dipropionate

33 Adrenal steroids & related drugs (4 decks)

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