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Medicine Phase 2a Haematology > Mind-maps Lymphoma > Flashcards

Mind-maps Lymphoma Flashcards

1
Q

2 types

A

Hodgkins

Non-Hodgkins

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2
Q

Hodgkins lymphoma - 4 most common histological subtypes

A

Lymphocyte-predominant
Modular sclerosing
Mixed cellularity
Lymphocyte-depleted

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3
Q

Cause of Hodgkins lymphoma

A 
Exact cause unknown
Risk factors:
Male sex
Infection with Epstein-Barr virus (EBV)
Immunosuppression e.g. HIV patients
Exotoxin exposure
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4
Q

Signs and symptoms of Hodgkins lymphoma

A 
Painlesss lymphadenopathy
Unintentional weight loss
Fever (constitutional 'B signs': fever >38 degrees, night sweats, weight loss)
Dyspnoea
Splenomegaly
Hepatomegaly
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5
Q

Investigations of Hodgkins lymphoma

A

Bloods
Histology
Radiology (X-ray, CT scan, PET scan)
Other - lymph node biopsy (Ann Arbor classification)

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6
Q

Blood investigations of Hodgkins lymphoma

A 
FBC, WCC, U and Es, CRP, ESR, 
Lactate dehydrogenase, 
Creatinine, 
Alkaline phosphatase, 
Serum cytokine levels
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7
Q

Conservative treatment of Hodgkins lymphoma

A

Patient education and referral to Macmillan nurses

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8
Q

Medical treatment of Hodgkins lymphoma

A

Depends on Ann Arbor claasification

AVBD regimen or BEACOPP regimen (acronyms for loads of drugs)

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9
Q

Complications of Hodgkins lymphoma

A 
Increased risk of infection
Recurrence and metastasis
Increased risk of cardiovascular disease
Complications of chemotherapy
Neurological complications
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10
Q

What is Non-Hodgkins lymphoma

A

Group of malignancies that are either B cell or T cell in origin

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11
Q

Example of B-cell Non-Hodgkins lymphomas

A

Burkitts lymphoma
Diffuse large B cell lymphoma
Mantle cell lymphoma
Follicular lymphoma

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12
Q

Translocations of following B-cell Non-Hodgkins lymphomas:
Burkitts lymphoma
Mantle cell lymphoma
Follicular lymphoma

A

Burkitts lymphoma t[8;14]
Mantle cell lymphoma t[11;14]
Follicular lymphoma t[14;18]

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13
Q

Example of T-cell Non-Hodgkins lymphomas

A

Adult T cell lymphoma
Caused by human T-lymphotrophic virus-1 (HTLV-1)
Sezary syndrome

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14
Q

Cause of Non-Hodgkins lymphomas

A

Exact cause unknown
Risk factors:
Male sex, Infection (Helicobacter pylori, HHV-8, Hep C), Immunosuppression (HIV)

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15
Q

Signs and symptoms of Non-Hodgkins lymphomas

A 
Painless lymphadenopathy
Unintentional weight loss
Fever
Dyspnoea
Splenomegaly
Hepatomegaly
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16
Q

Investigations of Non-Hodgkins lymphomas

A

Bloods
Radiology (X-ray, CT scan, PET scan)
Other - lymph node biopsy (Ann Arbor Classification)

17
Q

Blood investigations of Non-Hodgkins lymphomas

A 
FBC, WCC, U and Es, CRP, ESR, 
Lactate dehydrogenase, 
Creatinine, 
Alkaline phosphatase, 
Serum cytokine levels, 
Soluble CD25 level
18
Q

Conservative treatment of Non-Hodgkins lymphomas

A

Patient education and referral to Macmillan nurses

19
Q

Medical treatment of Non-Hodgkins lymphomas

A

Depends on causes and severity (Ann Arbor classification)

R-CHOP regimen

20
Q

Complications of Non-Hodgkins lymphomas

A 
Increase risk of infection 
Recurrence and metastasis
Increased risk of cardiovascular disease
Complications of chemotherapy
Neurological complications

Medicine Phase 2a Haematology (16 decks)

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