Milinirone and Ibuprofen

Question 1

What is Milnirone?

Answer 1

Milnirone is pulmonary vasodilator used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the hearts contractility and decrease pulmonary vascular resistance.
Milnirone is a vasodilator that is used as short term treatment for life threatening heart failure.

Question 2

When should Milnirone be administered?

Answer 2

For short term treatment of severe congenital heart failure unresponsive to conventional maintenance therapy, not immediately after myocardial infarction
Acute heart failure including low output states following heart surgery initially by intravenous injection

Question 3

What is the usually prescribed does for Milnirone?

Answer 3

Initially 50 mcg/kg, given over 10 min followed (by intravenous infusion) 375- 750 nanograms/kg/minute usually given following surgery for up to 12 hours or in congestive heart failure for 48- 72 hours.

Question 4

What are the contra- indications for Milnirone?

Answer 4

Severe hypovolaemia

Question 5

What are the side effects of Milnirone?

Answer 5

Common

• Arrhythmia supra ventricular (increased risk in patients with pre-existing arrhythmias
• headache
• hypotension

Uncommon

• Angina
• chest pain
• hypokalaemia
• tremor

Rare
- anaphylactic shock

Question 6

What needs to be monitored when on Milnirone?

Answer 6

• monitor blood pressure
• heart rate
• ECG
• central venous pressure
• fluid and electrolyte status
• renal function
• platelet count and hepatic enzymes

Question 7

What are the directions for administration for Milnirone?

Answer 7

• avoid extravasation
• For intravenous injection, may be given undiluted or diluted before use
• For intravenous infusion give continuously in Glucose 5% or sodium chloride 0.9% dilute to a suggested concentration of 200 mcg/mL

Question 8

What is ibuprofen?

Answer 8

• non steroidal anti- inflammatory drug class
• Postoperative analgesia
• Dental pain
• Mild to moderate pain including fever, inflammation, menstrual periods and migraines.
• Pain and inflammation in rheumatic disease and other musculoskeletal disorders

Question 9

What is ibuprofen used for?

Answer 9

• reduce fever
• inflammation
• minor aches and pain
• mild to moderate pain
• headaches
• rheumatoid arthritis
• common cold
• menstrual periods
• toothaches
• backaches

Question 10

What are the side effects of ibuprofen?

Answer 10

• constipation
• diarrhoea
• gas or bloating
• dizziness
• nervousness
• ringing in ears
• headache
• raised blood pressure
• vomiting

Question 11

What is the mode of action of ibuprofen?

Answer 11

• Ibuprofen is a NSAID and it works by blocking your body’s production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain and fever

Question 12

What are the contra indication for ibuprofen?

Answer 12

• You shouldn’t take ibuprofen if you have a history of a strong, unpleasant reaction to aspirin or other NSAID.
• stomach ulcer or if you have had one in the past
• severe heart failure

Question 13

What is the duration of action of ibuprofen?

Answer 13

• Duration of action of 400mg is at least 6 hours compared with 4-6 hours for ibuprofen 200mg or paracetamol

Question 14

What should you assess before giving ibuprofen?

Answer 14

Monitor signs of GI bleeding
Abdominal pain 
Vomiting blood 
Blood in stools 
Black stools