Migraines

Question 0

Receptors important for migraines

Answer 0

5HT1B and 1D -produce vasoconstriction in CNS

Reduce CGRP

Question 1

Mild analgesics

Answer 1

Aspirin, acetaminophen, ibuprofen, naproxen

Question 2

Migraine Pathophysiology

Answer 2

CGRP released -> vasodilation of cranial blood vessels-> increased pressure on cranial nerves! pain

Question 3

Migraine sxs

Answer 3

Unilateral throbbing HA
Nausea, vomiting
Photophobia 
Irritability 
GI tract reduced

Question 4

Butalbital and codeine

Answer 4

Migraine tx
Overuse can cause rebound HA
Combination analgesics

Question 5

Metoclopramide

Answer 5

Antiemetic

Increases GI motility

Question 6

Sumatriptan

Answer 6

5HT1 receptor
Vasoconstriction
Reduces n&v
Increases gi motility

Don’t use with MAOI or propranolol

Question 7

Dihydroergotamine

Answer 7

Perferred ergot alkaloid
Vasoconstriction
Can actually cause n&v
Don’t use with CYP3A4 inhibitors or cerebral and peripheral ischemia

Question 8

Butophanol

Answer 8

Migraine tx

Kappa opioid receptor agonist similar to Pentazocine

Question 9

Propranolol

Answer 9

B receptor agonist

Prophylactic tx of migraines

Question 10

Amitriptyline

Answer 10

Tricyclic antidepressant

Prophylactic tx of migraines

Question 11

Valproic acid

Answer 11

Anti-epilepsy drug

Prophylactic tx of migraines

Question 12

Botulinum toxin A

Answer 12

Prophylactic tx of migraines