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Pharm Test 3 > Drug Categorization > Flashcards

Drug Categorization Flashcards

1
Q

Fluoxetine

A

SSRI

Major Depressive Disorder

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2
Q

Sertraline

A

SSRI

Major Depressive Disorder

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3
Q

Duloxetine

A

SNRI
SERT inhibition > NET inhibition
Major Depressive Disorder

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4
Q

Amitriptyline

A

Tricyclic Antidepressant
SERT & NET inhibition
Major Depressive Disorder

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5
Q

Phenelzine

A

MAO-I
nonselective for A and B
Major Depressive Disorder

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6
Q

Selegiline

A

MAO-I
transdermal patch
Major Depressive Disorder

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7
Q

Buproprion

A

Atypical Antidepressant
DAT & NET inhibition; DAT inhibition > NET
Major Depressive Disorder
Smoking

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8
Q

Mirtazapine

A

Atypical Antidepressant
alpha-2 antagonist (increases 5HT & NE)
Major Depressive Disorder

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9
Q

Lithium

A

mood stabilizer

Bipolar Disorder

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10
Q

Morphine

A

Full opioid agonist

Schedule II

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11
Q

Codeine

A

Full opioid agonist

Schedule II

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12
Q

Methadone

A

Full opioid agonist
used to treat drug dependence at low doses
Schedule II

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13
Q

Fentanyl

A

Full Opioid agonist
transdermal patch for chronic pain
lozenge/film/tablet/nasal spray for acute tx
Schedule II

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14
Q

Hydrocodone

A

Full opioid agonist

Schedule II/III

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15
Q

Oxycodone

A

Full opioid agonist

Schedule II

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16
Q

Loperamide HCl

A

full opioid agonist

anti-diarrheal agent

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17
Q

Dextromethorphan

A

Antitussive

Cough suppressant

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18
Q

Pentazocine

A

Synthetic opioid
Partial agonist at Kappa
Antagonist/partial agonist at mu
Schedule IV

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19
Q

Buprenorphine

A 
Partial Agonist Opioid
Partial agonist at mu
Antagonist at Kappa
Schedule III
Opioid, alcohol, and cocaine dependence tx
20
Q

Tramadol

A

Very weak partial agonist opioid (mu)

inhibits NE and 5HT transport

21
Q

Naloxone

A

Opioid Antagonist

treats opioid overdose

22
Q

Tacrine

A

AChE Inhibitor
centrally acting noncompetitive inhibitor
Alzheimer Disease

23
Q

Donepezil

A

AChE inhibitor
selective reversible inhibitor of AChE in CNS
Alzheimer Disease

24
Q

Galantamine

A

AChE inhibitor
Reversible & competitive; modifies nicotinic receptors
AChE&raquo_space; BuChE
Alzheimer Disease

25
Rivastigmine
Pseudo-irreversible inhibitor of AChE; carbamate AChE > BuChE; binds at esteric site Alzheimer Disease
26
Memantine
non-AChe inhibitor non-competitive N-methyl-D-aspartic acid receptor antagonist blocks Ca2+ influx? Alzheimer Disease
27
Levodopa
Dopamine Synthesis Adjuvant bypasses the rate-limiting step in DA synthesis (tyrosine hydroxylase) Parkinson's Disease
28
Carbidopa
Dopamine Synthesis Adjuvant an aromatic amino acid decarboxylase inhibitor reduces levodopa metabolism in the periphery Parkinson's Disease
29
Pramipexole
Dopamine (D2) receptor agonist | Parkinson's Disease
30
Rotigotine
Dopamine agonist patch - can be used with levodopa or alone Parkinson's Disease
31
Selegiline
MAO-I (B) and irreversible | Parkinson's Disease - may slow disease process but studies raise doubts about its effectiveness
32
Entacapone
Catechol-O-methyl transferase (COMT) inhibitors | Parkinson's Disease
33
Trihexyphenidyl
anticholinergic | Parkinson's Disease
34
Amantadine
Antiviral used to reduce tremor and dyskinesia Blocks DA uptake, increases DA release, and blocks glutamate receptors Parkinson's Disease
35
Chlorpromazine
Typical Antipsychotic lower affinity to D2 vs Haloperidol Schizophrenia
36
Haloperidol
Typical Antipsychotic higher affinity to D2 vs Chlorpromazine Schizophrenia
37
Clozapine
Atypical Antipsychotic Schizophrenia Can be used in patients with Parkinson's
38
Quetiapine
Atypical Antipsychotic | Schizophrenia
39
Risperidone
Atypical Antipsychotic broadly effective for + and - sx Schizophrenia
40
Aripiprazole
Partial Agonist at D2 | Schizophrenia
41
Varenicline
alpha-4-beta-2 receptor partial agonist Abnormal dreams smoking tx
42
Clonidine
partial alpha-2 agonist smoking tx - not FDA approved Ethanol withdrawal sx tx Opioid withdrawal
43
Disulfiram
Etoh dependance treatment Antabuse vasodilation if alcohol consumed during treatment
44
Naltrexone
Mu opiate receptor antagonist EtOH treatment; binge drinking opioid dependence tx
45
Acamprosate Calcium
EtOH treatment | reduces craving and relapse

Pharm Test 3 (8 decks)

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