Drug Categorization Flashcards

1
Q

Fluoxetine

A

SSRI

Major Depressive Disorder

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2
Q

Sertraline

A

SSRI

Major Depressive Disorder

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3
Q

Duloxetine

A

SNRI
SERT inhibition > NET inhibition
Major Depressive Disorder

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4
Q

Amitriptyline

A

Tricyclic Antidepressant
SERT & NET inhibition
Major Depressive Disorder

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5
Q

Phenelzine

A

MAO-I
nonselective for A and B
Major Depressive Disorder

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6
Q

Selegiline

A

MAO-I
transdermal patch
Major Depressive Disorder

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7
Q

Buproprion

A

Atypical Antidepressant
DAT & NET inhibition; DAT inhibition > NET
Major Depressive Disorder
Smoking

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8
Q

Mirtazapine

A

Atypical Antidepressant
alpha-2 antagonist (increases 5HT & NE)
Major Depressive Disorder

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9
Q

Lithium

A

mood stabilizer

Bipolar Disorder

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10
Q

Morphine

A

Full opioid agonist

Schedule II

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11
Q

Codeine

A

Full opioid agonist

Schedule II

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12
Q

Methadone

A

Full opioid agonist
used to treat drug dependence at low doses
Schedule II

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13
Q

Fentanyl

A

Full Opioid agonist
transdermal patch for chronic pain
lozenge/film/tablet/nasal spray for acute tx
Schedule II

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14
Q

Hydrocodone

A

Full opioid agonist

Schedule II/III

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15
Q

Oxycodone

A

Full opioid agonist

Schedule II

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16
Q

Loperamide HCl

A

full opioid agonist

anti-diarrheal agent

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17
Q

Dextromethorphan

A

Antitussive

Cough suppressant

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18
Q

Pentazocine

A

Synthetic opioid
Partial agonist at Kappa
Antagonist/partial agonist at mu
Schedule IV

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19
Q

Buprenorphine

A
Partial Agonist Opioid
Partial agonist at mu
Antagonist at Kappa
Schedule III
Opioid, alcohol, and cocaine dependence tx
20
Q

Tramadol

A

Very weak partial agonist opioid (mu)

inhibits NE and 5HT transport

21
Q

Naloxone

A

Opioid Antagonist

treats opioid overdose

22
Q

Tacrine

A

AChE Inhibitor
centrally acting noncompetitive inhibitor
Alzheimer Disease

23
Q

Donepezil

A

AChE inhibitor
selective reversible inhibitor of AChE in CNS
Alzheimer Disease

24
Q

Galantamine

A

AChE inhibitor
Reversible & competitive; modifies nicotinic receptors
AChE&raquo_space; BuChE
Alzheimer Disease

25
Q

Rivastigmine

A

Pseudo-irreversible inhibitor of AChE; carbamate
AChE > BuChE; binds at esteric site
Alzheimer Disease

26
Q

Memantine

A

non-AChe inhibitor
non-competitive N-methyl-D-aspartic acid receptor antagonist
blocks Ca2+ influx?
Alzheimer Disease

27
Q

Levodopa

A

Dopamine Synthesis Adjuvant
bypasses the rate-limiting step in DA synthesis (tyrosine hydroxylase)
Parkinson’s Disease

28
Q

Carbidopa

A

Dopamine Synthesis Adjuvant
an aromatic amino acid decarboxylase inhibitor
reduces levodopa metabolism in the periphery
Parkinson’s Disease

29
Q

Pramipexole

A

Dopamine (D2) receptor agonist

Parkinson’s Disease

30
Q

Rotigotine

A

Dopamine agonist
patch - can be used with levodopa or alone
Parkinson’s Disease

31
Q

Selegiline

A

MAO-I (B) and irreversible

Parkinson’s Disease - may slow disease process but studies raise doubts about its effectiveness

32
Q

Entacapone

A

Catechol-O-methyl transferase (COMT) inhibitors

Parkinson’s Disease

33
Q

Trihexyphenidyl

A

anticholinergic

Parkinson’s Disease

34
Q

Amantadine

A

Antiviral used to reduce tremor and dyskinesia
Blocks DA uptake, increases DA release, and blocks glutamate receptors
Parkinson’s Disease

35
Q

Chlorpromazine

A

Typical Antipsychotic
lower affinity to D2 vs Haloperidol
Schizophrenia

36
Q

Haloperidol

A

Typical Antipsychotic
higher affinity to D2 vs Chlorpromazine
Schizophrenia

37
Q

Clozapine

A

Atypical Antipsychotic
Schizophrenia
Can be used in patients with Parkinson’s

38
Q

Quetiapine

A

Atypical Antipsychotic

Schizophrenia

39
Q

Risperidone

A

Atypical Antipsychotic
broadly effective for + and - sx
Schizophrenia

40
Q

Aripiprazole

A

Partial Agonist at D2

Schizophrenia

41
Q

Varenicline

A

alpha-4-beta-2 receptor partial agonist
Abnormal dreams
smoking tx

42
Q

Clonidine

A

partial alpha-2 agonist
smoking tx - not FDA approved
Ethanol withdrawal sx tx
Opioid withdrawal

43
Q

Disulfiram

A

Etoh dependance treatment
Antabuse
vasodilation if alcohol consumed during treatment

44
Q

Naltrexone

A

Mu opiate receptor antagonist
EtOH treatment; binge drinking
opioid dependence tx

45
Q

Acamprosate Calcium

A

EtOH treatment

reduces craving and relapse