Migraine Flashcards
1
Q
serotonin role in headaches
A
- alters threshold of pain perception
- serotonin 1 - vasoconstriction (prodrome)
- serotonin 2- vasodilation (pain of HA)
2
Q
migraine prophylaxis
A
beta blockers:
- propranolol
- amitriptyline
ergotamines:
- methysergide / sansert
- topiramate / topamax
3
Q
propranolol
A
- non-selective beta blocker
- HTN, angina, AMI, panic attack, migraine
- blocks adrenergic stimulation
- bronchoconstriction, hypotension, fatigue
4
Q
amitriptyline
A
- tricyclic antidepressant
- migraine/tension ha, chronic pain, bipolar, depression
- CNS modulation of both serotonin and norepi
- dizziness, drowsiness, dry mouth, constipation, blurred vision
5
Q
topiramate
A
- anticonvulsant
- epilepsy, migraine prophylaxis, bipolar disorder
- block voltage-dependant Na channels in CNS - GABA receptors
- fatigue, dizziness, vision changes, acute angle glaucoma, nausea, constipation
6
Q
methysergide
A
- ergot derivative, serotonin 2 receptor antagonist
- migraine prophylaxis
- serotonin 2 receptor antagonist leads to vasoconstriction
- lots os side effects = not great option (heart valve thickening)
7
Q
sumatriptan
A
- serotonin agonist
- prodromal phase migraine and cluster ha
- dizziness, tingling, facial flushing, chest tightness, HTN
- serotonin syndrome
8
Q
butorphanol
A
- opioid analgesic
- mixed agonist-antagonist of opioid receptors
- nasal irritation, drowsiness, dysphoria, N/V
- spray
