Gout Medications

Question 1

gout vs pseudogout

Answer 1

gout: uric acid chrystals, tophi, rat-bite on xray
pseudogout: effects larger joints, calcium pyrophosphate cyrstals, chondrocalcinosis on xray

Question 2

first line therapy for gout

Answer 2

NSAIDs

- if at risk for side effects from NSAIDs, give additional PPI

Question 3

Other Tx for Gout

Answer 3

Steroids

Colchicine

Question 4

prophylactic tx

Answer 4

colchicine
allopurinol
probenacid

Question 5

Indomethacin / Indocin

Answer 5

class: NSAID
indication: gout, arthritis, bursitis, migraine, pain and swelling, close patent ductus arteriosus
contraindications: pt with nasal polyps can develop angioedema, infants under 2 unless it is to close patent ductus arteriosus, pregnancy, nursing mothers

Question 6

Samter’s Triad

Answer 6

• asthma
• aspirin/NSAID sensitivity
• nasal polyposis

Question 7

colchicine

Answer 7

class: mitotic inhibitor
indication: gout
side effects: GI upset, anemia, neutropenia, hair loss, peripheral neuropathy
*can have toxic reaction

Question 8

allopurinol

Answer 8

class: purine analog, xanthine oxidase inhibitor
indication: hyperuricemia, gout, prophylaxis against tumor lysis syndrome
SEs: N/V, skin rash, SJS, hepatitis

Question 9

probenecid

Answer 9

class: uricosuric
indication: hyperuricemia, gout
SEs: N/V, gastritis, GI upset, renal stones