Midterms based questions- these are questions that popped up a lot

Question 1

what are the three drugs you prescribe him:

Answer 1

1. Atropine- muscarinic receptor antagonist 2. Benzodiazepin- reduces anxiety 3. Pralidoxime- it pulls the OP off of the molecule and reactivates the enzyme

Question 2

List 6 symptoms in that farmer that was expose to pesticides and you diagnose acute cholinergic crisis:

Answer 2

1. Salivation 2. Lacrimation 3. Urination 4. Defecation 5. Muscle twitching 6. anxiety

Question 3

Pentachlorophenol

Answer 3

ionophore that makes inner mitchondrial membrane leaky

Question 4

Cyanide-

Answer 4

inhibits cytochrome oxidase. Blocks function of electron transport chain

Question 5

Fluoroacetate-

Answer 5

prevents transport of electrons to ETC. Inhibits aconitase

Question 6

Black widow spider venom

Answer 6

release acetycholine from vessicles

Question 7

Botulinum-

Answer 7

binds to nerve receptor and block ACh release

Question 8

Ethylene glycol-

Answer 8

forms oxalate crystals in your kidney tubules

Question 9

tetrodotoxin

Answer 9

blocks sodium channels on neurons

Question 10

Organphosphorous chemicals-

Answer 10

inhibit acetycholine esterase (ACHe)

Question 11

Cocaine-

Answer 11

inhibits nor-epinephrine uptake

Question 12

DDT

Answer 12

over stimulates sodium channels on nucelus

Question 13

Atropine-

Answer 13

muscarinic receptor antagonist

Question 14

a-bungarotoxin-

Answer 14

binds covalently to nictonic receptors

Question 15

Rotenone-

Answer 15

Inhibits NADH- coenzyme Q reductase

disrupts electron carrier

Question 16

Carbon monoxide-

Answer 16

has a greater affinity for hemoglobin then O2 and therefore O2 cannot get to electron transport chain to make ATP.

Question 17

Chlordecone-

Answer 17

Inhibits ATP synthase

Question 18

what are the 5 distinct mechanisms by which xenobitoics can cause toxicity by inhipiting ATP synthesis”

Answer 18

1. Block trabsport of electrons to the electron transport chain 2. Block transport of oxygen to electorn transport chain 3. Block function of electron transport chain 4. inhibition of ATP synthase 5. uncouple electrochemical gradient

Question 19

Warfarin-

Answer 19

blood thinner, inhibition of clotting factors