Leftover stuff from ADME lecture

Question 1

Bioconcentration factor (BCF)=

Answer 1

concentration of xenobitoic in organisms/ concentration of xenobitoic in water

Question 2

Bioaccumulation:

Answer 2

the accumulation of a xenobiotic in the body. The overall uptake or accumulation of a xenobiotic from all exposure routes

Question 3

what is steady state?

Answer 3

is the concentration of where you want the drug to be. For a xenobiotic to be in
steady-state, the rate of excretion and rate of absorption
must be about the same—in equilibrium.

Question 4

Bioconcentration:

Answer 4

uptake is from water only in aquatic organisms

Question 5

time to steady state independent of dosage for what order only?

Answer 5

first oder

Question 6

Draw Physiologically-based pharmacokinetic (PBPK) models

Answer 6

Question 7

what is the fluctuations of steady state caused by:

Answer 7

1. Proportional to dosage interval/half-time 2. Blunted by slow absorption

Question 8

when is steady state attained?

Answer 8

attained after approximately 4 half times.

Question 9

steady state concentrations:

Answer 9

1. Proportional to dose/dosage interval 2. Proportional to F/CL

Question 10

Biomagnification:

Answer 10

increase concentration of a xenobiotic as you move up the food chain. Really only occurs with very lipid soluble xenobiotics.