(Midterm) Tablets/Capsules

Question 1

Which of the following is NOT correctly matched?
a. Nitrostat – Tablet for oral ingestion
b. Minidiab-OD – Extended-release tablet
c. Bonamine – Chewable tablet
d. Claritin Reditabs – Instant disintegrating tablet
e. Neozep – Multiple-compressed tablet

Answer 1

Nitrostat – Tablet for oral ingestion

Question 2

A type of stability test, which involves temperatures in 10-degree increments. This test is performed to identify the products of degradation of a product

Answer 2

Stress Test

Question 3

For rapid disintegration of compressed tablets, the concentration starch to used is;

Answer 3

10-15%

Question 4

A type of gelatin blend, which contributes to plasticity and clarity to the blend, thus reducing haze or cloudiness of the finished capsules

Answer 4

Pork skin gelatin

Question 5

This substance is used as an opaquant for gelatin capsule shells

Answer 5

Titanium dioxide

Question 6

Examples of primary packaging components
a. Rubber stoppers
b. Cotton fillers
c. Blister/strip packs
d. both a and b

Answer 6

both a and b

Question 7

A tablet formulation contains 2 actives, which are chemically incompatible. The best method to be used is;

Answer 7

Multilayered compression

Question 8

Strip-sealed tablets are evaluated for

Answer 8

leakers

Question 9

When preparing hard gelatin capsules, the formulator is not generally concerned with

Answer 9

Powder compaction

Question 10

Hard gelatin capsules are
1. Commonly employed in clinical trials
2. In small scale compounding, pharmacist uses “punch method”
3. Can be prepared by rotary die process

Answer 10

1,2 are correct

Question 11

Soft gelatin capsules
1. Are used to hermetically seal and encapsulate liquids, suspensions, and pasty materials
2. Render elastic and plastic-like by adding titanium dioxide
3. Contain more moisture than hard gelatin capsule

Answer 11

1 and 3 are correct

Question 12

An ideal property of tablet granulations in which the material forms a stable, compact mass when pressure is applied;

Answer 12

Compressibility

Question 13

The cause of capping, chipping and lamination of compressed tablets

Answer 13

Poor flow rate of granulations

Question 14

Most biological are store at this temperature

Answer 14

2-8 degree C

Question 15

Characteristics of added substances to capsule formulation
1. Harmless in quantities used
2. Do not interfere with requisite compendial assays and tests
3. Do not impair product’s bioavailability, therapeutic efficacy or safety

Answer 15

1,2,3 are correct

Question 16

The ff. statements are true for glidants/lubricants in tablet granulation;

Answer 16

reduce interparticulate friction, thereby improving the rate of flow of granulation

Question 17

This raw material can be used as a tablet diluents, disintegrant and binder

Answer 17

Corn starch

Question 18

The following are true about capsules EXCEPT
a. Capsule sealing is done for all capsules
b. Sorbitol is added to gelatin to make soft gelatin capsules
c. Calcium stearate can be used as a lubricant for the tablet and capsule powder formulation
d. The largest capsule size is 000

Answer 18

Capsule sealing is done for all capsules

Question 19

Uneven distribution of color on the surface of compressed tablets is called

Answer 19

Mottling

Question 20

The critical operation in sugar coating process of tablets leading to a 50% to 100% increase in tablet weight. This is the basis of an elegant tablet profile

Answer 20

Subcoating

Question 21

“Rule of Thumb” is the principle applied for testing

Answer 21

compressed tablets

Question 22

A method of preparation of tablets whose components are sensitive to moisture and elevated temperatures, during drying, yet possess inherent cohesive properties

Answer 22

Dry granulation method

Question 23

Which of the following dosage forms are designed to conceal the bitter, salty or offensive taste or odor of a drug substance?
1. Capsules
2. Coated tablets
3. Flavored syrups

Answer 23

1,2,3

Question 24

Talc, Leucine ,Carbowax 400, and colloidal silicon dioxide are employed as

Answer 24

Lubricant

Question 25

The most common method of manufacture of hard gelatin capsules that uses completely automatic machine, consisting of mechanisms for dipping, spinning, drying, stripping and joining the capsules

Answer 25

Pin Method

Question 26

Spansule capsule is
1. An example of extended-release product prepared by embedding drug in a slowly eroding hydrophilic matrix system
2. A capsule containing beads of different coating thickness
3. A half-colored, half-transparent hard gelatin capsule containing colored beads or granules

Answer 26

only 3 is correct

Question 27

The preferred bulking agent for chewable tablets, which provides an excellent mouth-feel, due to its pleasant, cooling effect

Answer 27

mannitol

Question 28

A mechanism involved in the preparation of sustained release tablets, wherein the drug material is applied with relatively thin coating material, ranging from several tenths of micron to 5000 microns in size

Answer 28

Microencapsulaltion

Question 29

In the preparation of effervescent tablets, the component/s necessary for the effervescent effect is/are
a. Sodium bicarbonate
b. Tartaric acid
c. Citric acid
d. all of the choices

Answer 29

all of the choices

Question 30

This plastic material is rigid and has good clarity thus, is used in blister packaging of capsules and tablets is

Answer 30

PVC