Midterm study Flashcards
Which class of antibody reacts best at room temperature?
IgG
IgM
IgE
IgA
IgM
IgG antibodies are clinically significant for HDN because:
-They are too big to escape the vein
-They fix compliment
-They demonstrate dosage
-They are small enough to cross the placenta
They are small enough to cross the placenta
Hemolysis is a positive reaction that indicates you have most likely identified antibodies that:
-React at AHG
-Fix Compliment
-Cross the placenta
-Are immune stimulated
Fix Compliment
Which of the following is known as the membrane attack complex in the classical pathway?
C1
C3
C4,C2,C3
C5bC6C7C8C9
C5bC6C7C8C9
True or False: Most Antigens we have discussed are inherited autosomal dominant
True
A father is Xga+ and his wife is Xga- what will the phenotypes of his offspring be?
-His daughters will be Xga+ and Sons will be Xga-
-His daughters will be Xga- and his sons will be Xga+
-All of his children will be Xga-
-All of his children will be Xga+
His daughters will be Xga+ and Sons will be Xga-
As RBCs are stored which of the following increases?
Plasma potassium
2,3 DPG
ATP
pH
Plasma potassium
What is the longest length of time that the FDA says red cells can be stored for?
51 days
42 days
35 days
28 days
42 days
When there is a shift to the left, hemoglobin affinity for oxygen does what?
Increases
Decreases
Increases
What is the maximum time a sample may be obtained before a transfusion for pre-transfusion testing?
24 hours
8 hours
3 days
7 days
3 days
The immunodominant sugar responsible for group B specificity is:
N-acetyl galactosamine
D-Galactose
Fucose
N-acetyl glucosamine
D-Galactose
What is the most common cause of the following results:
Anti-A: 3+mf
Anti-B: 4+
A1 cell: 0
B cell: 0
Bacterial infection
Transfusion
Hemolytic disease of the newborn
Immunocompromised
Transfusion
Acquired B antigens are found in which individuals?
Bombay individuals
Group O persons
All blood groups
Group A persons
Group A persons
(from galactosamine being cut off)
Which blood type should NOT result from the union of an AB male to an O female?
A
B
O
None of these
O
A child is blood typed as A, their mother is blood type B, what blood type must the father be?
A
B
O
Bombay
A
Which of the following statements is true?
-An individual with AO genotype is homozygous for A.
-An individual with BB genotype is homozygous for B.
-An individual with OO genotype is heterozygous for O.
-An individual with AB genotype is homozygous for A and B.
An individual with BB genotype is homozygous for B.
What blood type is the following patient:
Anti-A: 0
Anti-B: 4+
A1 cell: 4+
B cell: 0
A
B
O
AB
B
Which subgroup do you suspect from the following results:
Anti-A: 0
Anti-B: 1+mf
Anti-A,B: 1+mf
A1 cell: 3+
B cell: 0
A2
A3
B3
Bel
B3
An ABO type on a patient gives the following results, what is your next step?
Anti-A: 4+
Anti-B: 0
A1 cell: 0
B cell: 0
-Reverse type with A2 cells
-Forward Type with Anti-A,B
-Forward Type with A1 lectin
-Incubate at 4C for 5-10 minutes
Incubate at 4C for 5-10 minutes
You would use Ulex europaeus reagent to investigate what?
-A subgroup
-B subgroup
-Potential Bombay
-Cold agglutinin
Potential Bombay
Which bloodtype has the most amount of H substance?
A1
B
AB
O
O
If the patient with the following serological results was a secretor, what substances would that person have in their secretions?
Anti-A: 0
Anti-B: 4+
A1 cell: 4+
B cell: 0
B, Leb
Lea
Anti-A
nothing
B, Leb
The Lewis gene codes for a transferase that transfers a sugar onto precursor substance, what is that sugar?
Glucose
Fucose
Galactose
N acetylglucosamine
Fucose
A patient has HH, LeLe, sese, A genes. What antigens will be expressed on their red cells?
-A, H, Lea
-Lea only
-A only
-A, H, Lea, Leb
A, H, Lea
