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Blood bank > Midterm 2 study > Flashcards

Midterm 2 study Flashcards

1
Q

Which of the following reagents is used to facilitate hemagglutination following the sensitization of red cells with an IgG alloantibody?

-Anti-human globulin
-Low ionic strength saline
-Polyethylene glycol
-22% bovine albumin

A

-Anti-human globulin

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2
Q

After addition of IgG coated RBCs (check cells) to a negative AHG reaction during an antibody screen, a negative result is observed. Which of the following is the correct interpretation?

-The antibody screen is negative
-The antibody screen needs to be repeated
-The saline washings were adequate
-The antibody screen is positive

A

The antibody screen needs to be repeated

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3
Q

A patient serum reacts with 2 of 3 antibody screening cells at the AHG phase of testing. 8 of 10 cross-matched units were incompatible at AHG. ALL reactions were markedly enhanced with enzymes. Which antibody is likely reacting?

-Anti-M
-Anti-E
-Anti-c
-Anti-Fya

A

Anti-c

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4
Q

Which characteristics are true of all 3 of the following antibodies: anti-Fya, anti-Jka, anti-K?

-May show dosage, may cause severe hemolytic transfusion reactions
-Detected at IAT phase and may cause hemolytic disease of the newborn and transfusion reactions
-Not detected with enzyme treated cells, may cause delayed transfusion reactions
-Requires IAT technique for detection, usually not responsible for HDN

A

Detected at IAT phase and may cause hemolytic disease of the newborn and transfusion reactions

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5
Q

Which of the following neutralizing substances is accurately matched to its antibody?

-Breast milk = P
-Normal human plasma = Chido/Rogers
-Hydatid cyst fluid = Lewis
-Saliva - I

A

Normal human plasma = Chido/Rogers

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6
Q

In which of the following procedures would a positive agglutination reaction complete your workup?

-Rule in
-Rule out
-Phenotype testing of donor cell
-Phenotype testing of patient cell

A

-Rule in

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7
Q

McLeod syndrome is associated with nulls of which blood group?

-Kidd
-Kell
-Duffy
-Lutheran

A

Kell

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8
Q

Which of the following antigens appears on the antigram but does not need to be ruled out unless suspected because it is low incident?

-K
-Kpa
-Ina
-Xga

A

Kpa

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9
Q

An auto control gives a mixed field result, is this a valid test result?

-Yes, the result shows that the patient has an autoantibody
-Yes, the patient has probably been recently transfused
-No, the panel cells cannot give mixed field results, something is wrong with the test system
-No, the control has failed, the test must be repeated until it gives valid results

A

Yes, the patient has probably been recently transfused

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10
Q

Which antibody is NOT known to fix compliment?

-anti-Jka
-anti-P
-anti-B
-anti-k

A

-anti-k

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11
Q

Which antithetical pair is NOT a high/low incidence pair?

Lua/Lub
Dia/Dib
Fya/Fyb
K/k

A

Fya/Fyb

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12
Q

Which antibody is known to demonstrate dosage?

anti-Jka
anti-P
anti-Lea
Anti-U

A

anti-Jka

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13
Q

Which antigen system is the entry point for Plasmodium Falciparum?

MNS
Lutheran
Duffy
Rhesus

A

MNS

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14
Q

Secretor status is coded on chromosome 19, which of the following systems is also on this chromosome?

Kell
Duffy
Lutheran
P/Glob

A

Lutheran

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15
Q

Which antigen system is involved in urea transport in the cell?

Duffy
Kell
Kidd
P

A

Kidd

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16
Q

Which antibody is associated with paroxysmal cold hemoglobinuria?

anti-P1
anti-P
anti-M
Anti-I

A

anti-P

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17
Q

Which antibody classically gives mixed field agglutination reactions?

anti-Lea
anti-Lub
anti-I
Anti-D

A

anti-Lub

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18
Q

Which antibody is considered a warm acting antibody?

Anti-M
Anti-N
Anti-S
Anti-Lua

A

Anti-S

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19
Q

Which phenotype is NOT a null phenotype?

Jk3-
U-
Fy(a-b-)
k-

A

k-

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20
Q

Which antibody is most commonly associated with delayed hemolytic transfusion reactions?

anti-s
anti-k
anti-Lua
Anti-Jka

A

Anti-Jka

21
Q

Which of the following phenotypes may make an allo-anti-U?

M+N+S+s-
M+N-S-s-
M-N+S-s+
M+N-S+s+

A

M+N-S-s-

22
Q

Which phenotype is considered homozygous?

R1r”
Fy(a+b+)
Jk(a-b+)
K+k+

A

Jk(a-b+)

23
Q

Your facility has a rule to not phenotype units for antigens that are <10% prevalent in the population. Which clinically significant antibody might they miss?

E
Lea
S
K

A

K

24
Q

Which duffy phenotype is prevalent in the black population but nearly non-existent in caucasians?

Fy(a+b+)
Fy(a+b-)
Fy(a-b+)
Fy(a-b-)

A

Fy(a-b-)

25
Q

Which antigen of the Kell system is more frequent in the black population?

K
Kpa
Jsa
Jka

A

Jsa

26
Q

Which antibody is produced by the p null phenotype?

anti-p
anti-P
anti-P1
Anti-PP1Pk

A

Anti-PP1Pk

27
Q

Which antigen is created by the transferase that competes with Pk transferase?

I
N
Lea
H

A

H

28
Q

Which antigen is NOT strongly expressed at birth in cord blood?

K
I
Fya
M

A

I

29
Q

Which antigen activity is enhanced with treatment with enzymes?

MN
Duffy
Rh
None of them

A

Rh

30
Q

Which antigen would NOT be found on glycophorin B?

M
N
S
s

A

M

31
Q

Which red cell morphology occurs commonly when Kell antigens are missing from the red cell surface?

Spherocytes
Acanthocytes
Hypochromasia
Resistence to lysis in 2M urea

A

Acanthocytes

32
Q

How many units should you test to find 2 compatible blood units for a patient who has an anti-Fya?

1
3
5
10

A

5

33
Q

How many units should you test to find 1 compatible blood unit for a patient who has an anti-K, anti-E and anti-S?

1
3
9
5

A

3

34
Q

Which antigen on the antigram is NOT low incident?

Cw
V
Kpa
f

A

f

35
Q

Which of the following antibodies can be naturally occurring?

anti-K
anti-D
anti-S
anti-P1

A

anti-P1

36
Q

Choose the true statement for Anti-K.

Agglutinates in the IS phase of testing
Is usually IgM
Loses reactivity when tested with DTT treated cells
Does not agglutinate with K+k+ cells

A

Loses reactivity when tested with DTT treated cells

37
Q

Chronic granulomatous disease is associated with a depression of the antigens in the __system.

Duffy
Kidd
Kell
P

A

Kell

38
Q

Which of these lesser known antigens is not on the antigram because it is not clinically significant?

Ch
Dia
Ge2
Ytb

A

Ch

39
Q

A patient transfused 2 years ago had anti-Jkb. Now their screen is negative. What is the appropriate followup?

Antibody panel
Phenotype the patient for Jkb
Phenotype units for Jkb
Immediate spin Crossmatch

A

Phenotype units for Jkb

40
Q

An antibody that reacts with all cells on a panel except the autocontrol is referred to as…

High Titer Low Avidity (HTLA)
High Incidence
Low Incidence
Auto Antibody

A

High Incidence

41
Q

An antibody’s clinical significance refers to its ability to cause

HDN
HTR
Formation of antibody
Two of these

A

Two of these (HDN and HTR)

42
Q

True or False, after neutralization procedures, the patient plasma mixed with antigen positive cell should produce an agglutination result.

A

False

43
Q

True or False: After neutralization procedures, patient plasma mixed with antigen positive cell will NOT agglutinate.

A

True

44
Q

For what purpose would you choose a heterozygous cell?

Rule out
Rule in
Positive control for Phenotype
Negative control for Phenotype

A

Positive control for Phenotype

45
Q

Which of the following stock antibodies would be an appropriate negative control after enzymatic treatment of a panel?

Anti-c
Anti-Fyb
Anti-K
Anti-Jka

A

Anti-Fyb

46
Q

Which of the following is NOT a technique used to pretreat a red cell panel for complex antibody identification?

Hydatid Cyst fluid
Ficin
Papain
DTT

A

Hydatid Cyst fluid

47
Q

You are working on a patient you suspect has a high incidence antibody. You have only been able to authorize plasma transfusion for this patient while you wait for reference lab workup. The patient’s most recent sample is now giving negative results after plasma transfusion. What has happened?

The Chido/Rodgers antibody was neutralized by normal plasma.
The autoantibody was diluted by plasma transfusion.
The Lewis antibody was neutralized by normal plasma.
The incorrect patient was collected.

A

The Chido/Rodgers antibody was neutralized by normal plasma.

48
Q

You are attempting to differentiate anti-S from anti-M. Which of the following information is most helpful?

The patient diagnosis is Malarial infection.
The patient antibody reacts with 8 out of 12 cells on the antigram.
The patient antibody is non agglutinating with enzyme treated panel.
The patient has an ABO discrepancy of extra reactions in the reverse type.

A

The patient has an ABO discrepancy of extra reactions in the reverse type.

Blood bank (4 decks)

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