Midterm Review Flashcards
Modality
Application of some form of stress to the body for the purpose of eliciting an adaptive response
Phases of Healing: 1. Inflammatory Response Phase
- Chemical messengers elicit local and systemic effects, cells remove debris, and cells create groundwork for repair/regeneration
- Lasts 3-4 days
- Purpose: protect, localize and prepare for healing
Vasoconstriction
-Immediate response to injury: Norepinephrine limits blood loss
Vasodilation
- Occurs after Vasoconstriction due to the release of chemical mediators; Histamine and Leukotaxin
Cardinal Signs of Inflammation
- Heat
- Redness
- Swelling
- Pain
- Loss of function
WBCs and Inflammatory Response
Leukocytes:
- Margination = move to endothelial lining
- Pavementing= Line the endothelium in a tightly packed formation
- Chemotaxis = Drawn to injures site
- Phagocytosis begins
Clotting cascade
Permanent stop of blood loss from injure area
Fibrin patch
Fibrin forms the blood clot or scab over injured site
Phases of Healing: 2. Fibroblastic Repair
- Starts around 48-72 hrs after injury and may go on for 6 weeks
- 2 parts:
a. Granulation phase
b. Fibroblastic or proliferative phase
Fibroblastic Phase: a. Granulation
- Growth of new tissue(re-epithelialization)
- development of new blood vessels (angiogensis)
- development of fibrous tissue (Fibroplasia)
- Granulation tissue forms= connective tissue matrix
Fibroblastic Phase: b. Proliferation of fibroblasts
- accelerated laying down of collagen
- collagen matrix forms
Phases of Healing: 3.Maturation (remodeling phase)
- 3 weeks after injury
- Can last up to 2 years (majority 2 months)
- Granulation tissue replaced with Collagen fibers
- TYPE 3 collagen replaced with TYPE 1 collagen
Repair vs. Regeneration
Repair= tissues heal with a scar Regeneration = Actual tissue is replace (i.e. bone)
Fracture Healing: Phase I
Acute Phase: up to 1 week
- Hematoma forms= platelets (angiogensis)
- begins to develop fibrocartilage callus
Fracture Healing: Phase II
Repair/Regeration: up to 8-12 weeks
-Soft callus to hard callus: cartilage to bone occurs after week 3
Fracture Healing:
Phase III
Remodeling Phase: Resorption of callus
- as callus is removed trabecular bone lays down(may take years)
- Osteoblasts and Osteoclasts remodel the bone based on mechanical loading (Wolff’s Law)
Norepinephrine
causes Vasoconstriction; underlies “fight or flight” response
Enkephalins
Reduce pain perception by bonding to pain receptor sites
Endorphins
Morphine-like neurohormone; thought to increase pain threshold by bonding to pain receptor sites (generated by noxious stimuli)
Serotonin
Substance that causes local vasodilation and increase permeability of capillaries (generated by noxious stimuli)
Dorsal Nerve roots
Transmit:
- Sensory
- Afferent information
Ventral Nerve roots
Transmit:
- Motor
- Efferent information
Afferent Pathways: First order neuron
-connects to peripheral sensory receptor and projects info to DRG in SC. Synapses with cell body of second order neuron in DRG
Afferent Pathways: Second order neuron
cell body located in DRG
-crosses the midline and ascends to the thalamus
Afferent Pathways: Third order neuron
cell body in the thalamus and projects to cortex
Afferent Nerves (1st order)
- Aalpha(Ia and Ib): Large, thick myelin, fastest:Ia=muscle spindle; Ib=GTO
- Abeta: Large, thick myelin, fast = light touch, vibration, hair deflection
- Adelta: Small, Myelin, slow(fast pain) = Sharp pain, temp
- C: Smallest, unmyelin, slow pain = dull diffuse pain, intense pressure, extreme temp
Superficial Sensory Receptors
- Mechanoreceptors (pressure, skin stretch)
- Thermoreceptors
- Nociceptors: free nerve endings(pain)
Deep Sensory Receptors
- Proprioceptors: GTO, m. Spindle
- Nociceptors: Pain
- Mechanoreceptors: change in m length, tension
Paleospinothalamic Tract
“slow pain”
- Nociceptor
- 1st order neuron(C fiber) to laminae II and III of DRG horns: Substantia gelatinosa
- Synapses in dorsal horn and activates nociception-specific neurons in lamina I and II and becomes 2nd order neuron
Neospinothalamic Tract
“fast pain”: lasts as long as noxious stimuli
- Nociceptor
- 1st order neuron(Adelta) to DRG
- 2nd order neuron crosses and sends info to thalamus
- 3rd order neuron from thalamus to sensory cortex
Gate control Theory
- Located in Substantia gelatinosa (DRG II and III)
- Goal is to activate more Abeta fibers than C fibers to close gate
Descending Pain Modulation: Central Biasing theory and Endogenous Opiates Theory
-Stimulation of the PAG(midbrain) and NRM(pons/medulla) causes enkephalins and serotonin to inhib ascending neurons
Subjective Pain Assessment
- duration
- Freq
- Intensity
- Description
- Worse/Better
- Patterns
- Previous S&S
- Night Pain
Objective Pain Assessment
- Visual Analogue Scale: “1-10” with just a line instead
- Mcgill Pain Questionnaire: description of pain
- Pain Disability Index: 1-10 scale of disability on activities
Nagi’s Disablement Model
- Pathology: injury
- Impairment: Abnormality at site of injury
- Functional Limitations: limits in actions
- Disability: Limits in activities/roles
- Quality of Life: Health Related quality of life
Voltage
Amount of electrical pressure
Amplitude
The max distance that a pulse rises above or below the isoelectric baseline (flow)
Direct Current
- Uninterrupted, unidirectional flow of electrons
- Always cathode(neg) to anode(pos)
- Used for Iontophoresis: repels neg electrons to site of injury
Pulse duration
Horizontal distance of the shape of the pulse (pulse width)
Pulse Charge
the area within the waveform
Alternating Current
-Direction of current flow(amps) changes from positive to negative in a cyclical manner(no true pos or neg pole)
AC Freq vs. Cycle Duration
Frequency: cycles per second(Hz) or pulses/sec
Cycle duration: Inversely related to freq
Monophasic Current
- Unidirectional flow of electrons
- One phase per pulse
- depolarize nerves
- Create muscle contractions
Biphasic Currents
- Flow of electrons marked by periods of non-current flow
- each pulse has 2 phases (neg&pos)
Biphasic Symmetrical Current
- Comfortable for pt.
- Net charge of zero
- Neg to pos
- Use: NMES
Biphasic Asymmetrical: Unbalanced vs Balanced phases
Net Pos or Neg effect
- Unbalanced: 2 phases do not carry equal charges
- Use:NMES
- Balanced: 2 phases carry equal but not mirrored charges
- Use: TENS
Pulse Charge
- Measure of the number of electrons within a pulse(area in a waveform)
- Measured in MicroCoulombs
Pulse Frequency
- Number of events(pulses or cycles) per second
- Cycles/second (Hz)
Current Density
- Volts per square inch
- Inversely proportional to the size of electrode pad
Duty Cycle
Amount of time the current is flowing on as opposed to flowing off
-i.e. 10sec on/50 sec off
Proximity of Electrodes
Determine:
- Which tissue stimulated
- Depth of Stim
- Number of Parallel circuits
Selective Stim of Nerves
3 Factors to depolarize nerves:
- Diameter of nerve
- Sensory Abeta fibers
- Motor nerves
- Adelta and C: noxious - Depth of the nerve fiber in relation to the electrode
- Duration of the pulse or phase: Shorter pulse, more intensity that can be delivered
The Law of Dubois Reymond
- Sufficient Intensity: to cause depolarization of the cell membrane
- Steep enough ramp: rise must be rapid enough to prevent accommodation
- Duration Length: Duration length must be long enough in one direction that the nerve has time to depolarize
- Sufficient time for repolarization
Prevention of Accommodation
- Amp/Intensity
- Phase duration/Phase pulse
- Frequency
- Ramp
- Burst
E-Stim Uses
Muscle contraction: -Prevent atrophy(post surgery) -Neuromuscular re-education -Edema reductioin Pain control: Gate and descending pathway mod
Contraindications of E-Stim
- Cardiac dysfunction
- Pacemakers
- Pregnant
- Cancerous lesions
- Infected tissue
- Exposed implants
- Unstable fx
Iontophoresis
- Direct Current to drive neg or pos drug to patients skin/tissue
- Useful for acute epicondylitis
- Monopolar(dispersive pad)
- Quantity of ions delivered is the amount of charge delivered
- Dose = Current/Time
1. Dexamethasone(neg): inflammation
2. Lidocaine/dex or lido/epi (pos)= pain control
Sensory (High) Transcutaneous Electrical Nerve Stimulation(TENS):
Asymmetrical balanced biphasic current:
- Intensity= to contract then back off(sensory)
- Freq= 60-100 pps
- Pulse width=60-100pps
- Duration=as needed(all day)
- Onset Relief=less than 10 min
- Lasting relief=mins to hours
- Uses Gate Control