Midterm module 3 analgesics

Question 1

What are adjuvant analgesics

Answer 1

Drugs that are added for combined therapy with a primary drug that may have additive or combined independent properties
(NSAIDs, non-opioid analgesics, anticonvulsants, antidepressants, corticosteroids)

Question 2

what is the classification of ASA

Answer 2

NSAID / Antipyretic

Question 3

how is ASA available

Answer 3

Tablets & suppositories, enteric coated 81mg-975 mg

Question 4

what are the indications of ASA

Answer 4

Inflammatory disorders
mild to mod pain
fever
prophylaxis of TIA & MI

Question 5

what is the mechanism of action of ASA

Answer 5

Inhibiting prostaglandin synthesis, decrease platelets aggregation

Question 6

what are the side effects of ASA

Answer 6

Nausea, Tinnitus, GI bleeding

Question 7

what are the pre-post checks for ASA

Answer 7

Allergies, pain, under 19 should not take post viral infections

Question 8

what are the teaching aspects of ASA

Answer 8

Give with full glass of water, food. Don’t give enteric coated with milk

Question 9

What is the classification of Ibuprofen

Answer 9

NSAID, antipyretic

Question 10

what is the availability of ibuprofen

Answer 10

tablets 200-400mg

Question 11

what is the indication of ibuprofen

Answer 11

Inflammatory disorders, mild to moderate pain, fever

Question 12

what are the mechanism of action of ibuprofen

Answer 12

inhibit prostaglandin synthesis

Question 13

what are the side effects of ibuprofen

Answer 13

nausea, GI bleed, HR MI, stroke

Question 14

what are the pre checks for ibuprofen

Answer 14

Hx of GI bleed, renal insufficiency

Question 15

what is the teaching for ibuprofen

Answer 15

Give with a full glass of water, food avoid alcohol

Question 16

what is the classification of acetaminophen

Answer 16

Non-narcotic analgesic, antipyretic

Question 17

what is the availability of acetaminophen

Answer 17

Tablet, supp. liquid

Question 18

what is the indication of acetaminophen

Answer 18

Treatment of mild pain & fever

Question 19

what is the mechanism of action of acetaminophen

Answer 19

inhibiting enzymes necessary for prostaglandin synthesis

Question 20

what is the onset of acetaminophen

Answer 20

Rapid.

peak = 0.5-2 hr duration is 3-4 hours

Question 21

what are the side effects of acetaminophen

Answer 21

hepatoxicity

Question 22

whats the max amount of acetaminphen a day

Answer 22

4g

Question 23

what is the classification of gabapentin

Answer 23

Analgesic adjuncts, anticonvulsants

Question 24

what are the indications for gabapentin

Answer 24

Neuropathic pain, migranes, anxiety & diabetic neuropathy

Question 25

what are the side effects of gabapentin

Answer 25

Increased risk of suicidal thoughts & behaviours, confusion, drowsiness

Question 26

what organ should you be concerned about with gabapentin

Answer 26

renal

Question 27

what is the teaching for gabapentin

Answer 27

May cause dizziness & drowsiness - do not take within 2 hours of antacid. suicidal thoughts

Question 28

what is amitriptyline class

Answer 28

antidepressant with unlabelled uses for anxiety & chronic pain

Question 29

what is the mechanism of action for amitriptyline

Answer 29

Potentiates the effect of serotonin & NE in the CNS

Question 30

what are the side effects of amitriptyline

Answer 30

May increase risk of suicide attempt/ideation, ssedation, leathery, hypotension, constitpation

Question 31

what are the pre checks for amitriptyline

Answer 31

BP & Pulse & renal insufficiency

Question 32

what is the teaching for amitriptyline

Answer 32

may cause dizziness, blurred vision, monitor suicide

Question 33

what are the high efficacy vs low efficacy narcotics

Answer 33

``` hi efficacy - Morphine sulfate -Fentanyl -Methadone -Dilaudide moderate efficacy -codeine ```

Question 34

what is the classification of morphine

Answer 34

Opioid analgesic

Question 35

what is the mechanism of action of morphine

Answer 35

binds to opiate receptors in the CNS. Alters the perception of & response to painful stimuli while producing generalized CNS depression.

Question 36

what is the onset for morphine

Answer 36

Rapid. peak = 60 minutes. Durations - up to 7 hours

Question 37

what are the side effects of morphine

Answer 37

respiratory depression & consitpation

Question 38

pre checks for morphine

Answer 38

RR, BP

Question 39

what is the mechanism of methadone

Answer 39

binds to opiate receptors in the CNS. Alters the perception of & response to painful stimuli while producing generalized CNS depression.

Question 40

what is the indication of methadone

Answer 40

Moderate to severe chronic pain in opioid-tolerant patients requiring 24/7 opioid tx

Question 41

basics of equianalgesic opiod conversion for chronic pain

Answer 41

-Po is always more than parenteral (around double)