Midterm 2 Flashcards
What are MSCs?
Mesenchymal stem cells
Where are MSCs produced/located?
Bone marrow
What can MSCs differentiate into?
Adipocyte (fat), Chondrocyte (cartilage), Osteocyte (bone)
What does ECM stand for?
Extra cellular matrix
What is a ECM?
Space between the cells
What is included in the ECM?
Ground substance (fluid matrix), connective tissue fibres, and connective tissue cells.
What are the functions of the ECM?
Structural and nutritional support, and white blood cells chill here and fight off infection
What is the ECM comprised of?
15% water, 30% collagen fibres, and 55% mineralized crystal salts (calcium phosphate)
What is calcification?
Minerals are deposited into the framework of collagen fibres. They crystalize and tissue hardens.
What does the hardness of bone depend on?
Crystalized inorganic salts
What does the flexibility of bone depend on?
Depends on organic collagen fibres
What are the four main types of bone cells?
Osteogenic, osteoblasts, osteocytes, and osteoclasts.
What are osteogenic cells?
Stem cells that become osteoblasts
What is growth?
Change in mass
What is Remodeling?
evolution of material properties without change in mass
What is morphogenesis?
embryonic time where new tissues and cell differentiation occurs
What is a major difference between living on water vs living on land?
Gravity
What are the fundamental differences between having large vs small mass?
Smaller sizes give a better surface area to volume ratio meaning metabolic activity is usually quicker. This means there is more demand on smaller sizes (changes within the organism occur more quickly).
What is ontogeny?
Development of an individual
What does ontogeny rely on?
Primarily genetics, but can change via environmental factors
What allometry?
ratio changes of certain structures within the organism (can be either positive or negative)
What is isometry?
everything grows at the same rate
What is arithmetical growth mean?
Grows constant
What is exponential growth mean?
Grows quickly
What is biomechanics?
Animals must function to
interact with their
environment and meet
physical demands to be
successful!
What are the three parts of a lever system?
effort, load, and fulcrum
What are tendons?
Connective tissue connecting muscle to bone
What are ligaments?
Connective tissue connecting bone to bone
What are joints?
Any connection between skeletal elements
What are the three types of joints?
Fibrous joints (tight together), cartilaginous joints (more flexibility), and synovial joints (free moving)
Why are synovial joints special?
Include slippery cartilage with synovial fluid
What are the different types of synovial joints?
- Ball and socket- hip
- Pivot- atlas and axis
- Hinge- elbow, knee
- Saddle-shaped- thumb
- Planar or gliding-
carpal bones - Condyloid- wrist
What do lever ratios tell us about appendages?
Short arm produces force, long arm produces speed
What types of stress can occur?
Compression, tension, and shear
What are tissue responses to stress?
Use, disuse, or mechanical loading history