MIDTERM #1--WEEK 7 Flashcards
______________:
The presence of specific sign(s) or symptom(s) suggesting with almost certainty that the target condition is present
Pathognomonic
Test __________ is the ability of a test to correctly identify those with the disease (true positive rate)
sensitivity
Test ______ is the ability of the test to correctly identify those
without the disease (true negative rate)
specificity
Example: If 100 without a disease are tested, 90 have a negative result; the test has 90% specificity
Differential Diagnoses =
“ALL THE CONDITIONS THAT APPEAR ______”
Example: A patient with back & leg pain differential diagnoses may include: Disc herniation Facet syndrome Muscular strain SI Joint injury Piriformis syndrome
SIMILAR
______ ________: “A working
hypothesis formulated from significant items in history and physical findings, a tentative diagnosis; or a working diagnosis.”
Clinical Impression
Selected Disorders of the Lumbar Spine
____% of all adults will suffer from an episode of LBP at some time in their life
2nd only to the common cold as a cause of lost days at work
One of the most common reasons for visits to a doctor’s office or emergency department
80
Selected Disorders of the Lumbar Spine
Good news: most LBP is uncomplicated with recovery in about ____ weeks
Estimated 90% will self-resolve within ___-_____months
— Not so good news: 10% of patients do NOT return to normal function even after 2 months
Pose the greatest challenge to practitioners Enormous economic burden on society
NOTE: cLBP is the MOST common cause of disability in Americans younger than ____ years
6
1–2
45
Selected Disorders of the Lumbar Spine
Encouraging News:
~____% of Americans with LBP seek chiropractic care
• Evidence on clinical effectiveness supports the use of manipulation for acute LBP and helps resolve symptoms and restore function of chronic LBP
40
Selected Disorders of the Lumbar Spine
In total,_______% of workers who initially visited a surgeon underwent surgery, in contrast to only 1.5% of those who first consulted a chiropractor
42.7
Selected Disorders of the Lumbar Spine
- Disc disruption: _____%
- Facet involvement:___-______%
- Compression fracture: 4%
- Spondylolisthesis: 3%
- Malignant Neoplasm: 1%
- Ankylosing Spondylitis: 0.3% • Spinal Infection: 0.01%
39
15-40
Selected Disorders of the Lumbar Spine
LBP Etiology continued…….
• Spinal Stenosis - common in older population
coupled or enhanced by ___________ processes
• Sacroiliac (SI) Joint
• Other (Prostate, Aneurysm, kidney, female reproductive organs )
degenerative
Selected Disorders of the Lumbar Spine
Mechanical LBP (97%)
• Muscle/Ligament
– ______/_________, MFPS, fibromyalgia
• Bone/Joint
–_________ syndrome, arthritis, fracture, osteoporosis spondylolisthesis
• Nerve
– Compression/irritation (lateral, central canal), disc, inflammation
Strain/sprain,
Facet
Selected Disorders of the Lumbar Spine
Spinal pain is multifaceted, involving structural, biomechanical, biochemical, medical, and psychosocial influences that result in dilemmas of such complexity that treatment is often _______ or __________”
difficult
ineffective
Selected Disorders of the Lumbar Spine
Non-Spinal/Visceral Disease (___%)
• Aortic aneurysm
• Pelvic organs
– Prostatitis, pelvic inflammatory disease, endometriosis
• Renal organs
– Nephrolithiasis (kidney stones),pyelonephritis
(infection of the kidney and the ureters)
• Gastrointestinal system
– Pancreatitis, cholecystitis
2
Selected Disorders of the Lumbar Spine
Anatomy of the IVD
Centralportion:
The _____ _______which is composed of cells from the primitive notochord
• Outerportion:
The _____ ______composed of concentric layers of intertwined annular bands - resist forces placed on the lumbar spine
• Subdivided into:
Inner fibers, connected to the cartilaginous endplate
Outer Sharpy fibers, attached to the VB
nucleus pulposus
annulus fibrosis
Selected Disorders of the Lumbar Spine
ALL and PLL further strengthen the disc space
• ____ resists forces applied in extension
stronger ligament than the PLL
• The _____ resist flexion forces
Strongly attaches to the annulus fibrosis
Frequently is torn in cases of free fragment disc herniation
ALL
PLL
Selected Disorders of the Lumbar Spine
There is a distinction between an ______ disc and a degenerated disc
Although unfortunately, often considered synonymously
Difficult to differentiate changes that occur solely due to aging from those that might be considered pathological
Degeneration = _________
aging
Disease
Selected Disorders of the Lumbar Spine
The Aging Disc
ALL discs undergo age related changes
Age related changes occur in ALL collagenous tissue starting at ______
• Can be accelerated by ______
birth
trauma
Selected Disorders of the Lumbar Spine
Normal Disc Aging
• 1st changes occurs in the nucleus
Changes from soft gel into an mix of fibrous lumps with softer materials adjacent to endplates
Produce fewer proteoglycans therefore,
Water content _________
Accelerated by oxidative stress from ________ compromise
Tissue more brittle, prone to injury
• ________=physically stiffer
decreases
nutritional
Dehydrated
Selected Disorders of the Lumbar Spine
The strength of the lumbar disc is related to the fluid and proteoglycan content of the disc (Proteoglycan is a ___________)
hydrophilic
Selected Disorders of the Lumbar Spine
Disc Properties
_______ = Gradual deformation of the disc when under a constant load. Loading expresses ___% of water from disc during the day – most of water loss is from ________
• Non-degenerated disc:creep is very SLOW
• Injured disc:Creep/deformation can be RAPID–more vulnerable to prolapse – less able to recover
Creep
20
nucleus
Selected Disorders of the Lumbar Spine
Disc Degeneration
Very common in humans but, NOT an inevitable consequence of ______
Aging, apoptosis, abnormalities in collagen, vascular changes, loads placed on the disc, and abnormal proteoglycans, loss of disc nutrition
• May lead to loss of height of motion segment with concomitant changes in biomechanics of segment.
Disc space __________ is NOT normal = Degeneration
aging
narrowing
Selected Disorders of the Lumbar Spine
—Etiology: Disc Degeneration—
One of the primary causes of disc degeneration is thought to be failure of the _______ supply to the disc cells
• Can be affected by several factors that affect the blood supply to the vertebral body such as:
_____________appear to lead to a significant increase in disc degeneration
Long-term _______or lack of it appears to have an effect on movement of nutrients into the disc, and thus on their concentration in the tissue
nutrient
Atherosclerosis
exercise
Selected Disorders of the Lumbar Spine
Disc Degeneration
3 phases of progressive degenerative
changes in the annulus nuclear complex:
- ___________:= Circumferential and radial tears
- __________:= Internal disruption and disc resorption
- _________:= Osteophytes and traction spurs. Can lead to stenosis
Dysfunction
Instability
Restabilization
Selected DISORDERS of the Lumbar Spine
Pathomechanical Disc Degeneration
1–• _________ tears = From shear stresses from loading in bending and torsion
2–• ___ _____ = Circumferential avulsions of the peripheral annulus with sclerosis and osteophytosis of the adjacent bone
3–• Internal disc disruption =Inward buckling
4–• Radial fissures = Starting from the inner annulus sometimes progressing to the outer margins of disc so,
5–• NP material can then _________ resulting in disc prolapse = Protrusion, extrusion or sequestration
Circumferential
Rim lesions
escape
Selected Disorders of the Lumbar Spine
Disc degeneration alters disc height and the mechanics of the rest of the spinal column.
Possibly adversely affecting behavior of other spinal structures such as _____ and ligaments
• Associated with _______ and disc herniation or prolapse
Long term:
• Can lead to _____ _______, a major cause of pain and disability in the elderly
• Apophyseal joints adjacent to discs subject to abnormal loads and eventually develop osteoarthritic changes
muscles
sciatica
spinal stenosis
Selected Disorders of the Lumbar Spine
2 phases of IVD prolapse/herniation:
- ________ __________= Displaced nuclear material causing the outer annulus to bulge
- ________ _________= Nuclear material escapes from the disc.
***________ most often occurs on the posterior or posterolateral aspect of the disc partially due to arrangement of the annular fiber bundles appear. Directs the herniation toward the exiting and traversing nerve roots.
Annular Protrusion
Nuclear Extrusion
Herniation
Selected Disorders of the Lumbar Spine
Disc Herniation
1—__________ Disc– Nucleus protrudes through inner but NOT the outer layer of the annulus
(outer annular fibers intact)
2---\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ Disc – Nuclear material penetrates completely through annulus (annular fiber ruptured) • Beneath the PLL • Penetrate the PLL or • Sequestered
Contained
Non-Contained
Selected Disorders of the Lumbar Spine
—Lumbar Disc Herniation / Prolapse—
1—Bulge:
- Mild displacement of the annular fibers probably due to a slight nuclear displacement
- Involves at least ___% of the circumference of the disc, but may involve up to 100%-
The ____ is intact. Bulge may be caused by disc degeneration, response to loading or angular motion, or even a normal variant.
50
PLL
Selected Disorders of the Lumbar Spine
—Lumbar Disc Herniation / Prolapse—
2–Protrusion:
– A focal outcropping of the annulus
– The fibers of the annulus are thinned with some tearing
– The _______ moves through the ‘tears’ usually in a posterior direction
– PLL is intact
nucleus
Selected Disorders of the Lumbar Spine
—Lumbar Disc Herniation / Prolapse—
3—___________:– Rupture of the annular fibers so that the nuclear material emerges through the annulus
– NP remains confined by the PLL
Extrusion
Selected Disorders of the Lumbar Spine
Clinical Consideration
Patients with severe back pain and sciatica are almost 3 times as likely to have a disc _______
On MRI examination of the lumbar spine, many people without back pain have ____ _____ or _________ but NOT extrusions
extrusion
disk bulges
protrusions
Selected Disorders of the Lumbar Spine
—Lumbar Disc Herniation / Prolapse—
4—______________:
– PLL is disrupted and the nucleus protrudes into the epidural space
– Displaced disc tissue is expelled from disc and is no longer attached to it.
***The _____ and ______ of disc herniation DOES NOT correlate with the degree of patient pain, disability, or suffering
Sequestration
size
severity
Selected Disorders of the Lumbar Spine
Disc Lesion – Immune Response?
RECALL: NP has no blood supply – segregated from immune system
Herniated disc material causes an _______ reaction due to the release of irritating substances and/or an autoimmune inflammatory reaction
inflammatory
***Immune inflammatory response causes further degradation
• Result:herniation & irritation or compression of nerve root.
*****It had been suggested by recent studies that the herniation does NOT regress back into the annulus, but actually shrinks from resorption, desiccation, and phagocytosis!!
Selected Disorders of the Lumbar Spine
_____% of lesions are to L4-L5 or L5-S1
Classic Presentation and Symptoms
– Sudden onset of back pain with sharp pain into the leg past the knee, to the foot
– Usually follows twisting or bending injury
– Often a past Hx of several bouts of LBP that resolved
– Pain is made worse with coughing, bearing down, sneezing
• Signs
– Pain with palpation, splinting, edema, spasm
98
Know
Selected Disorders of the Lumbar Spine
L5-S1 Disc
• \_\_\_\_% probable if 3 S1 signs are present: 1. Pain projection into the S1 area • sciatic 2. Pathologic achilles DTR 3. Sensory deficit in S1 dermatome
86
Selected Disorders of the Lumbar Spine
L4-L5 Disc • \_\_\_\_\_% probable if 3 L5 signs are present: 1. Ext. Hallicus weakness 2. Pain projection into the L5 area • posterolateral thigh/calf 3. Sensory deficit of L5 dermatome
87%
Selected Disorders of the Lumbar Spine
Characteristics of Disc Injuries
1--Bulge – Pain increases with flexion – Flexion is limited – No radicular pain – Neuro exam is negative – X-rays are negative – Probably \_\_\_\_\_\_\_\_\_
asymptomatic
Selected Disorders of the Lumbar Spine
Characteristics of Disc Injuries
2--Protrusion – Pain \_\_\_\_\_\_\_\_\_ with flexion – All ROM limited to some degree – Somatic and/or radicular pain – Antalgia – Neuro exam may be normal or be deficit – X-ray: decreased disc angle or decreased lordosis or decreased lumbosacral angle
increased
Selected Disorders of the Lumbar Spine
Characteristics of Disc Injuries
3---Extrusion – Pain increases with flexion – Radicular and somatic \_\_\_\_\_\_\_\_\_ pain – Antalgia – (+) Dural Tension Signs – Hard Neurological Signs (abnormal) – MRI evident – X-ray same as protrusion
referred
Selected Disorders of the Lumbar Spine
Characteristics of Disc Injuries
4—Sequestration
– Back pain history that suddenly Changes to predominantly leg pain
– Early dural tension signs that may have disappeared
Unrelenting paresthesia/pain
– MRI
– Posterior migration of the free fragments:
______ __________ syndrome
(rare/immediate referral)
Cauda Equina
Selected Disorders of the Lumbar Spine
Lower Vs. Upper Lumbar Nerve Root Pathology
______ ________: : (L4), L5, S1, S2, S3
______ _________: L2, L3, L4
Sciatic Nerve
Femoral Nerve
Selected Disorders of the Lumbar Spine
Imaging and Special Testing
1–Do NOT reveal herniation; but do help exclude other conditions
(eg. fracture, cancer, infection)
2–NOTE: consider whether disc herniation
is ______ OR ________ to nerve root
medial or lateral
Selected Disorders of the Lumbar Spine
Epidural STEROID Injections
- Used in attempt to relieve back and lower limb pain associated with disc conditions with or without nerve root involvement
- Typically used when patient has primary leg pain or pain that is too _______ for less invasive management
- Early patient satisfaction reported – diminishes over time
- Complications exist
- Limited evidence about how well injections actually work and limited agreement on when they should be used
severe
***In the absence of: loss of bowel or bladder control and of progressive neurological deficit most patients are suitable for 2-3 month trail of conservative management before proceeding with surgery
Selected Disorders of the Lumbar Spine
Suspicion of cauda equina syndrome or __________ neurological deficits warrant surgical consultation to avoid progressive or irreversible neurological deficits
progressive
Select Disorders of the Lumbar Spine PART 2
Lumbar Stenosis—Common and complex degenerative disorder in the aging population
WHAT ARE THE 2 TYPES??
Central Stenosis
Foraminal Stenosis
Select Disorders of the Lumbar Spine PART 2
Foraminal Stenosis
IVF Stenosis = Reduction in size of the space at the IVF due to: – \_\_\_\_\_\_ \_\_\_\_\_\_\_\_\_\_ – \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ – Tumor – Osteophytes
Disc Herniation
Spondylolisthesis
***Spondylolisthesis is a condition in which a bone (vertebra) in the spine slips out of the proper position onto the bone below it.
Select Disorders of the Lumbar Spine PART 2
Central Stenosis
Cause:= Bony or soft tissue encroachment often at ______ ________.
multiple levels