MIDL3 Adrenal Function Flashcards
Produces steroid hormones & neuropeptides
essential for life
Adrenal gland
Example of Steroid hormones
Cortisol, Aldosterone, DHEA-S
Example of neuropeptides
Atrial Natriuretic Peptide(ANP)
The most pathologic conditions are linked by their
effects on ________
blood pressure and electrolyte balance
Hypofunction (decreased secretion) =
Treated with hormone replacement
Hyperfunction (increased secretion) =
Treated with pharmacologic suppression and/or surgery
EMBRYOLOGY AND ANATOMY are composed of:
Outer adrenal cortex: Yellow
Inner adrenal medulla: Dark Mahogany
COLOR
Outer adrenal cortex:
Inner adrenal medulla:
Outer adrenal cortex: Yellow
Inner adrenal medulla: Dark Mahogany
Adrenal gland shape
Pyramid shaped
Adrenal gland location
Above and medial to kidneys
Arterial supply is (symmetric/asymmetric)
symmetric
Adrenal gland is also known as
Suprarenal gland
Adrenal cortex by zone
Zona glomerulosa cells
Zona fasciculata cells
Zone reticularis cells
Outer 10%
Zona Glomerulosa cells
Middle 75%
Zona fasciculata
Inner 15 %
Zona reticularis
Synthesize mineralocorticoids (aldosterone) critical
for sodium retention, potassium excretion,
acid–base homeostasis, and regulation of blood
pressure
Zona Glomerulosa
Synthesize glucocorticoids (cortisol, cortisone, and
corticosterone) critical to blood glucose
homeostasis & blood pressure
Zona fasciculata
Synthesize adrenal androgens
(dehydroepiandrosterone sulfate (DHEA-S),
androstenedione, and testosterone) and estrogens
Zona reticularis
Aldosterone release is regulated by the ___
RAAS
Cords of clear cells with high cytoplasmic-to-nuclear
ratio and lipids laden with foamy cytoplasm
Zona fasciculata
In this layer, the DHEA produced by the F-Zone can
be sulfated/converted to DHEA-S
Zona reticularis
