Mid Week 8 Flashcards
GLOMERULAR DISORDER is Immune origins that Increased production/ circulation of _____________ (especially __________)
Immunoglobulin / IgA
GLOMERULAR DISORDER has nonimmunologic
- exposure of chemical and toxin
- electrical charge disruption (nephrotic syndrome)
GLOMERULAR DISORDER decomposition of immune complex which is
Amyloidosis
GLOMERULAR DISORDER that sterile inflammatory process of glomerular membrane and associated with finding blood, protein, and cast in urine
Glomerulonephritis
Decompositin of immune complex formed of Group A streptococuss infection
Acute poststreptococcal glomerulonephritis
Sudden onset of symptoms that damage the glomerular membrane
Acute poststreptococcal glomerulonephritis
Symptoms of Acute Poststreptococcal Glomerulonephritis:
H2OF2E
- hypertension
- hematuria
- oliguria
- fever
- fatigue
- edema
Caused by Acute Poststreptococcal Glomerulonephritis:
SPEC
- severe infection
- pneumonia
- endocarditis
- certain strain of group A Streptococcus (Streptococcus pyogenes)
Findings of Acute Poststreptococcal Glomerulonephritis
HIP3O
- hematuria
- increase blood urea nitrogen level
- presence of cast (RBC, WBC, hyaline, granular cast)
- positive ASOtiter
- proteinuria
- oliguria
It is more serious form that can lead renal failure
Rapidly progressive (crescentic) glomerulonephritis
Poor prognosis
Rapidly progressive (crescentic) Glomerulonephritis
Damage the capillary wall of bowman’s space
Rapidly progressive (crescentic) glomerulonephritis
Production of crescentic formations: rapidly progressive (crescentic) Glomerulonephritis
- macrophages
- fibroblast
- polymerized fibrin
Decomposition of immune complex from systemic immune disorders
Rapidly progressive (crescentic) glomerulonephritis
Findings of rapidly progressive (crescentic) glomerulonephritis
VES
- very low glomerular filtration rate
- elevated protein levels
- similar to acute poststreptococcal glomerulonephritis
Due to cytotoxic antibody ( anti glomerular basement membrane)
Goodpasteur syndrome
Autoantibody attachment and complement activation cause damage to capillary (anti glomerular basement membrane antibody)
Goodpasteur syndrome
Goodpasteur syndrome: patient initial complaint
Hemoptysis dyspnea followed by hematuria
Disorder of systematic vascular system and immune mediated
Vasculitis
What sickness is under vasculitis
- wegener’s granulomatosis
- henoch-schönlein purpura
Antineutropil cytoplasmic that binds neutropils
Wegener’s granulomatosis