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IP 142 > Micromeritics > Flashcards

Micromeritics Flashcards

1
Q

Science and technology of small particles

A

micromeritics

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2
Q

unit of measurement of micromeritics

A

micrometer

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3
Q

T/F smaller particle size –> intimate contact of drug and dissolution medium –> inc solubility and dissolution

A

T

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4
Q

Applications of micromeritics

A

Release and dissolution, Drug Absorption and action, Physical stability, Dose uniformity

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5
Q

T/F Inc solubility and dissolution decreases rate of absorption and slow onset of action

A

F increases and fast

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6
Q

T/F smaller particles increase stability

A

T

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7
Q

Methods of determining particle size

A

Optical microscopy, feret’s diameter, martin’s diameter, projected area diameter, sieving, sedimentation, particle volume measurement

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8
Q

T/F optical microscopy provides 3D images

A

F

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9
Q

particle size of optical microscopy

A

0.2-100 um

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10
Q

particle size of sieving

A

40-9500 um

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11
Q

T/F increasing mesh number decreasing particle sze

A

T

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12
Q

Apparatus used in Sedimentation

A

Andreasen apparatus

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13
Q

particle size of sedimentation

A

0.8-300 um

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14
Q

Law followed by sedimentation

A

stoke’s law

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15
Q

Terminal settling velocity of particles through a liquid medium in a gravitational centrifugal movement using Andreasen Apparatus

A

Sedimentation

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16
Q

Size of particle size measurement

A

0.5-300 um

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17
Q

Powder is suspended in an electrolyte solution and is made to flow thru a short insulated capillary section between 2 electrodes and the resistance of the system is measured

A

Particle size measurement

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18
Q

Machines in particle volume measurement

A

Coulter-Counter, HIAC/Royco, Gelman Counter

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19
Q

properties that are defined individually

A

Fundamental properties

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20
Q

properties that are dependent on the fundamental properties

A

derived properties

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21
Q

examples of derived properties

A

density, porosity, packing arrangement, flow properties

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22
Q

examples of fundamental properties

A

size and shape, size distribution

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23
Q

difference between the bullk volume and true volume

A

void volume

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24
Q

measure of the void volume in a powder material

A

porosity

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25
Q

total volume of the material

A

bulk volume

26
Q

T/F bulk volume is measured with a beaker

A

F. grad cyl

27
Q

equal to true volume + interparticle pores

A

specific granule volume (Vg)

28
Q

equal to true volume + interparticle pores + spaces between pores

A

specific bulk volume (Vb)

29
Q

excludes the volume of pores and interparticle spaces

A

true density or absolute density

30
Q

instrument to measure true or absolute density

A

helium densitometer

31
Q

includes the pore volume but excludes the interparticle spaces

A

apparent or envelope density

32
Q

apparent or envelop density is based on

A

liquid displacement

33
Q

includes both pore volume and interparticle spaces

A

Bulk density

34
Q

describes the packing of particles or granules

A

Bulk density

35
Q

Method I for Bulk density

A

Graduated cylinder

36
Q

Method II for Bulk density

A

Volumeter

37
Q

example of volumeter

A

scott volumeter

38
Q

Method III for Bulk density

A

Vessel

39
Q

Define bulk density:

  1. increase granule size

2. less spherical

A
  1. decrease

2. decrease

40
Q

T/F an increase in BD will cause an increase in porosity hence increasing interparticle contact and inc cohesion

A

F. decrease porosity dapat

41
Q

reflects maximum packing density of a powder achieved under the influence of well-defined, externally applied force

A

Tapped density

42
Q

ease with which a powder will flow under a set of conditions

A

Powder flowability

43
Q

T/F angle of repose is an intrinsic property

A

F

44
Q

T/F angle of repose depends upon the method used

A

T

45
Q

Characteristic of the internal friction or cohesion of the particles

A

Angle of repose

46
Q

T/F if powder is very cohesive, the heap is characterized by only one angle of repose

A

F. >1

47
Q

measures the angle of pile of material at rest and gives some recognition of a powders ability to flow

A

angle of repose

48
Q

T/F rough and more irregular surface of particles –> lower angle of repose

A

F. Higher dapat

49
Q

T/F compressibility index is an intrinsic property

A

F

50
Q

measures propensity of a powder to be compressed

A

Compressibility facto

51
Q

T/F Higher Carr’s compressibility index, more free flowing

A

F

52
Q

T/F higher hausner ratio, less free flowing

A

T

53
Q

more cohesive powders have hausner ratio greater than ___

A

1.6

54
Q

T/F coarse spheres have high interparticle friction

A

F low

55
Q

T/F free flowing powders have closer values of bulk and tapped densities

A

T

56
Q

give 2 manufacturing problems

A

uneven powder flow; caking; segragation in blending; transfer of powders thru hoppers

57
Q

Stages in tablet formation

A

Die filling, Tablet formation, Tablet rejection

58
Q

Components of a tablet press

A

HDPCFUD

59
Q

pharmaceutical process that converts a mixture of powders, which have poor cohesion, into aggregates capable of compaction

A

Granulation

60
Q

T/F Granulation prevents seggragation

A

T

IP 142 (5 decks)

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