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IP 142 > 1st Exam > Flashcards

1st Exam Flashcards

1
Q

Extent of solubility of a substance in a specific solvent is measured as

A

Saturation concentration

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2
Q

Results when the simultaneous and opposing processes of dissolution and phase joining proceed at a constant rate

A

Equilibrium solubility

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3
Q

Standard technique to determine thermodynamic aqueous compound solubilty

A

Shake Flask Method

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4
Q

Factors affecting solubility

A

NHSSSPP

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5
Q

Examples of particle size reduction

A

Micronization and sprayd drying

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6
Q

Rely upon mechanical stress to disaagregate active compound

A

Particle Size Reduction

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7
Q

Physical means to improve solubility

A

PDMC

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8
Q

Chemical ways to improve solubiltiy

A

pBDCS

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9
Q

Refers to a group of solid products consisting of at least two different components, a hydrophilic matrix and hydrophobic drug

A

Solid Dispersion

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10
Q

Used to prepare fast release solid dispersion dosage forms

A

Hot-Melt Method

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11
Q

Advantage is the use of a lower temperature

A

Solvent Evaporatiog method

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12
Q

Same as fusion method but with intense mixing of the components

A

Hot-Melt Extrusion

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13
Q

Biphasic system consisting of nano sized drug particles stabilized by surfactants for either topical and oral use or parenteral and pulmonary administration

A

Nanosuspension

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14
Q

Applied to poorly soluble drugs that are insoluble in water and oi

A

Nanosuspension

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15
Q

Types of nanosuspension

A

PMHC

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16
Q

Suspension is prepared using high-sheer media filling

A

Media filling

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17
Q

Suspension of a drug and surfactant is forced under pressure through a nanosized aparture valve of a high pressure homogenizer

A

High Pressure Homogenizer

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18
Q

Technique in which precipitated particle suspension is homogenized which preserves the particle size

A

Combined precipitation and homogenization

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19
Q

Ibuprofen is BCS class?

A

2

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20
Q

Characteristics of a well designed drug product

A
  1. Precise dose in each dosage form
  2. Working according to a prescribed regimen
  3. Physically stable and appealing
  4. Clearly labeled with storage conditions and expiration date
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21
Q

Do not possess dissociable ions, freely soluble in in water

A

Non electrolyte

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22
Q

Composed of metal ions and electronegative elements

A

Inorganic acids bases and salts

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23
Q

Majority of the pharmaceutical and medicinal agents

A

Organic acids and bases

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24
Q

Best describe acid-base behavior

A

pKa and pH

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25
Q

For systemic infections, weak acid, pKa of 6.3, crystallize in low pH –> kidney damage

A

Sulfadiazine

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26
Q

Weak acid, pKa of 5.0. For UTI

A

Sulfisoxazole

27
Q

Acidic, COOH group attached to the bicyclic ring called cephem

A

Cephalosporin

28
Q

Instability of B lactam is the reason why it is poorly absorbed from the GI tract, IM for systemic infections

A

Cefoxitin

29
Q

Contains and amino group at the cephalosporin side chain, resistant to acid, for UTI

A

Cefalexin

30
Q

Tropine ester of racemic tropic acid, weak base because tertiary amine group

A

Atropine

31
Q

Display both basic and acidic characteristics

A

Amphoteric Drugs

32
Q

if pKa > pKb of basic group, ampholytes are…..

A

Ordinary ampholytes

33
Q

pKa

A

Zwitterionic

34
Q

Capable of donating more tha proton

A

Polybasic Acids

35
Q

Capable of accepting two or more protons

A

Polyacidic bases

36
Q

Mixtures of weak acid and its salt or weak base and its conjugate acid

A

Buffer

37
Q

Effectiveness of a buffer in minimizing pH change

A

Buffer capacity

38
Q

Process molecules undergo when they are transferred from the solid to the dissolved state

A

Dissolution

39
Q

Reflects the effect of solubility and particle size of the drug raw material

A

Dissolution

40
Q

Reflects the effect of formulation and manufacturing process variables

A

Disintegration

41
Q

For non oral dosage forms

A

Drug release

42
Q

Routinely used for QC and R and D

A

Dissolution

43
Q

Noyes whitney

A

Dm/dt=DA(Cs -C)/h

44
Q

Compendial buffers

A

pH = 1.2-6.8

45
Q

Factors influencing in vitro

A

PPC

46
Q

Factors influencing invivo

A

VpCHT

47
Q

Volume of fasted stomach

A

20-50mL

48
Q

Capacity of human stomach

A

1-1.6 L

49
Q

Fasted small intestine volume

A

120-350 mL

50
Q

Fed state of small intestine

A

1.6 L

51
Q

Fluid flow volume in the intestines

A

9L

52
Q

pH of gastric juice of fed stomach

A

Up to 5

53
Q

pH of gastric juice of fasted stomach

A

1.5-2.9

54
Q

pH of fasted small intestine

A

6-7.1

55
Q

pH of fed small intestine

A

5.5-6.5

56
Q

Steps in dissolution test

A

AMDSFSC

57
Q

Preparation of medium

A

Method of Deaeration

Heat 41 degC
Sonicate
Filter using 0.45 um or less

58
Q

Name all apparatus with number

A 
1- rotating basket
2- paddle assembly
3- reciprocating cylinder
4- flow through cell
5-paddle over disk
6- rotating cylinder
7- reciprocating holder
59
Q

First line apparatus in product development of controlled release preparationg

A

Reciprocating cylinder

60
Q

For testing of products of poorly soluble drugs and chewable tablets, prevent cone formation

A

Reciprocating cylinder

61
Q

For IR tablets and sugar coated tablets; suppositories, soft gelatin capsules semisolids powders granules and implants

A

Flow-through Cell

62
Q

Specifically useful for transdermal patch

A

Rotating cylinder

63
Q

Proposed apparatus 8

A

Franz diffusion cell/vertical diffusion cell

64
Q

Property of a solid, liquid or gaseous solute to dissolve in a solid, liquid or gaseous solvent to form a homogenous solution

A

Solubility

IP 142 (5 decks)

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